Publications by authors named "Yoshihiro Tachihara"
Article Synopsis
- * Boronic acid (BA) derivatives can bind to sialic acid (SA) in the acidic environment of tumors, making them potentially useful for targeting CSCs.
- * This study demonstrates that BA-ligand fluorescence conjugates can effectively target various CSC subpopulations simultaneously, unlike traditional antibody-ligand methods which focus on one at a time.
Messenger RNA (mRNA) delivery strategies are required to protect biologically fragile mRNA from ribonuclease (RNase) attacks to achieve efficient therapeutic protein expression. To tackle this issue, most mRNA delivery systems have used cationic components, which form electrostatically driven complexes with mRNA and shield encapsulated mRNA strands. However, cationic materials interact with anionic biomacromolecules in physiological environments, which leads to unspecific reactions and toxicities.
View Article and Find Full Text PDFLipid molecules such as glycolipids that are modified with hydrophilic biopolymers participate in the biochemical reactions occurring on cell membranes. Their functions and efficiency are determined by the formation of microdomains and their physical properties. We investigated the morphology and properties of domains induced by the hydrophilic-polymer-modified lipid applying a polyethylene glycol (PEG)-modified lipid as a model modified lipid.
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