Functional connectivity during monitoring for visuomotor incongruence.

Previous human studies on monitoring for visuomotor incongruence emphasized the contribution of the fronto-parietal network and revealed significant activation of the right dorsolateral prefrontal cortex (DLPFC) and the right rostral inferior parietal lobule. Using functional MRI, this study investigated the brain regions involved in explicit monitoring for incongruence between motor intention and visual and/or proprioceptive information, particularly focusing on the fronto-parietal network. During in-phase bimanual movements, a static image of the participant's own hands was randomly inserted within real-time visual feedback of the movements to produce a mismatch between the actual performance and the visual input.

Long-term safety and efficacy of bilastine following up to 12 weeks or 52 weeks of treatment in Japanese patients with allergic rhinitis: Results of an open-label trial.

Objective: Bilastine is a novel second-generation antihistamine. This open-label, single-arm, phase III study evaluated the safety and efficacy of long-term treatment with bilastine in Japanese patients with seasonal (SAR) or perennial allergic rhinitis (PAR).

Methods: Patients with SAR or PAR who met the registration criteria and did not violate the exclusion criteria received bilastine (20mg, once daily) for 12 weeks (treatment period).

Overexpression of ErbB4 is an independent marker for lymph node metastasis in Japanese patients with oral squamous cell carcinoma.

Objective: Overexpression of the epidermal growth factor receptor (EGFR) family is common in oral squamous cell carcinoma (OSCC). Therefore, we analyzed the expression profiles of the four EGFR family members (ErbB1, ErbB2, ErbB3, and ErbB4) in OSCC of Japanese patients.

Study Design: Sixty-eight primary tumors and 18 normal oral mucosal tissue specimens were evaluated in this study.

Efficacy and safety of bilastine in Japanese patients with perennial allergic rhinitis: A multicenter, randomized, double-blind, placebo-controlled, parallel-group phase III study.

Background: Bilastine, a novel non-sedating second-generation H antihistamine, has been approved in most European countries since 2010. This study aimed to evaluate the superiority of bilastine over placebo in Japanese patients with perennial allergic rhinitis (PAR).

Methods: This randomized, double-blind, placebo-controlled, parallel-group, phase III study (trial registration number JapicCTI-142600) evaluated the effect of a 2-week treatment period with bilastine (20 mg once daily), fexofenadine (60 mg twice daily), or a matched placebo (double dummy) in patients with PAR.

Development of phase-separated scintillators with light-guiding properties.

Alkali halide systems that function as phase-separated scintillators (PSSs) with light-guiding properties are sucessfully created. Furthermore, it is the matrix phases of the PSSs which display the light-guiding properties. CsI-NaCl:Tl is a practical material pair because of its high pixel light output and good spatial resolution.

[Regression of metastatic hepatic cancer from gastric cancer by polysaccharide K and UFT administration--a case report].

Various treatments for hepatic metastasis of gastric cancer have been attempted, but problems remain with respect to long-term effectiveness and recurrence. Case reports have indicated the tumor regression effect of polysaccharide K(PSK)combined with chemotherapy, and meta-analysis has shown that PSK combined with chemotherapy improves the prognosis compared to chemotherapy alone. However, marked improvement of disease following PSK administration is rarely reported.

Effect of pretreatment with fexofenadine on the safety of immunotherapy in patients with allergic rhinitis.

Background: Allergen-specific immunotherapy, although not a cure, remains the only treatment available that can alter the natural course of an allergic disease. However, the risk of allergen specific immunotherapy-related systemic reactions (SRs), reported to occur in approximately 1% to 14% of patients and which can range from mild to fatal in seriousness, represents a barrier to implementing this unique and effective treatment option.

Objective: To explore the possibility that pretreatment with the H1-antihistamine fexofenadine could prevent the occurrence of severe SRs induced by immunotherapy in Japanese patients with allergic rhinitis.

Room-temperature grating-based morphological hole burning in Sm2+-doped glass powders.

We have observed grating-based morphological hole burning in Sm2+-doped glass powders at room temperature. When photobleaching on the 4f(6)-4f(5)5d transition of Sm2+ is combined with multiple light scattering, holes are produced in frequency and wave-vector domains. The hole profile depends on the amount of light absorption of Sm2+; it sharpens as the absorption decreases.