Cu Complexes of Tripodal Amine Ligands' In Vivo Tumor and Liver Uptakes and Intracellular Cu Distribution in the Extrahepatic Bile Duct Carcinoma Cell Line TFK-1: A Basic Comparative Study.

Copper (Cu) is a critical element for cancer cell proliferation and considerably accumulates in the nucleus. Cu is an anticancer radiopharmaceutical that targets the copper requirement of cancer cells. However, intravenously injected Cu ions primarily accumulate in the liver.

Trace Metal Impurities Effects on the Formation of [Cu]Cu-diacetyl-bis(-methylthiosemicarbazone) ([Cu]Cu-ATSM).

[Cu]Cu-diacetyl-bis(-methylthiosemicarbazone) ([Cu]Cu-ATSM) is a radioactive hypoxia-targeting therapeutic agent being investigated in clinical trials for malignant brain tumors. For the quality management of [Cu]Cu-ATSM, understanding trace metal impurities' effects on the chelate formation of Cu and ATSM is important. In this study, we conducted coordination chemistry studies on metal-ATSM complexes.

Circularly Polarized Absorption and Luminescence of Semiconductor Eu-OCN Nanocrystals in the Blue Region of the Electromagnetic Spectrum.

Semiconductor nanomaterials with efficient polarized-light control in the blue region of the visible spectrum are promising candidates for modern and future photo-information technology, display devices, and optical sensing applications. New-type semiconductor Eu(OCN) nanocrystals with circularly polarized absorption (CD: circular dichroism) and emission (CPL: circularly polarized luminescence) under an applied magnetic field are demonstrated here for the first time. The effective CD signal at 1.

Crystal structures, magnetic properties, and DFT calculation of B-site defected 12L-perovskites BaLaMWO (M = Mn, Co, Ni, Zn).

The synthesis, crystal structures and magnetic properties of BaLaMWO (M  =  Mn, Co, Ni, Zn) were investigated. They crystallize in the 12-layer polytype of the perovskite structure with a regular cation defect in the B-site. The results of neutron diffraction measurements reveal that they adopt a rhombohedral structure with a space group R  -  3 and have a cation ordering between Ba and La ions in the A-site.

PET Tracer F-Fluciclovine Can Detect Histologically Proven Bone Metastatic Lesions: A Preclinical Study in Rat Osteolytic and Osteoblastic Bone Metastasis Models.

F-Fluciclovine (-1-amino-3-F-fluorocyclobutanecarboxylic acid; -F-FACBC) is a positron emission tomography (PET) tracer for diagnosing cancers (e.g., prostate and breast cancer).

Fasting Enhances the Contrast of Bone Metastatic Lesions in F-Fluciclovine-PET: Preclinical Study Using a Rat Model of Mixed Osteolytic/Osteoblastic Bone Metastases.

F-fluciclovine (-1-amino-3-F-fluorocyclobutanecarboxylic acid) is an amino acid positron emission tomography (PET) tracer used for cancer staging (e.g., prostate and breast).

Magnetic Properties of the Melilite-Type Oxysulfide SrMnGeSO: Magnetic Interactions Enhanced by Anion Substitution.

The synthesis, crystal structures, photoluminescence, and magnetic properties of the melilite-type oxysulfide SrMnGeSO were investigated. This compound crystallizes in the melilite structure with space group P4̅2m, in which two kinds of anions, S and O, occupy different crystallographic sites in an ordered manner. The temperature dependence of the magnetic susceptibility of SrMnGeSO shows a broad peak due to a two-dimensional magnetic interaction between Mn ions in the ab plane.

A Novel CYP11B2-Specific Imaging Agent for Detection of Unilateral Subtypes of Primary Aldosteronism.

Context: Although adrenal vein sampling is the standard method to distinguish unilateral from bilateral forms of primary aldosteronism, it is an invasive and technically difficult procedure. (11)C-metomidate (MTO)-positron emission tomography was reported as a potential replacement for adrenal vein sampling. However, MTO has low selectivity for CYP11B2 over CYP11B1.

Crystal Structures and Magnetic Properties of Nickel Chain Compounds PbM2Ni6Te3O18 (M = Mn, Cd).

The synthesis, crystal structures, and magnetic properties of the pentanary oxides PbM2Ni6Te3O18 (M = Mn and Cd) were investigated. These compounds crystallize in a hexagonal structure with space group P63/m, in which the Ni(2+) ions form a zigzag chain along the c axis. From the magnetic susceptibility and specific heat measurements, we found that the PbCd2Ni6Te3O18 behaves as a low-dimensional magnet due to the intrachain antiferromagnetic interaction between Ni(2+) ions.

Evaluation of trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid accumulation in low-grade glioma in chemically induced rat models: PET and autoradiography compared with morphological images and histopathological findings.

Introduction: Magnetic resonance imaging (MRI) can have a problem to delineate diffuse gliomas with an intact blood-brain barrier (BBB) especially when a marked peritumoral edema is present. We evaluated the potential of trans-1-amino-3-(18)F-fluorocyclobutanecarboxylic acid (anti-(18)F-FACBC) positron emission tomography (PET) to delineate the extent of diffuse gliomas by comparing PET findings with autoradiography, in vivo and ex vivo MRI, and histopathology findings.

Methods: Dynamic PET was performed in rats with N-ethyl-N-nitrosourea-induced glioma for 60 min after anti-(18)F-FACBC injection.

Amino acid PET tracers are reliable markers of treatment responses to single-agent or combination therapies including temozolomide, interferon-β, and/or bevacizumab for glioblastoma.

Introduction: We examined whether the amino acid PET tracers, trans-1-amino-3-(18)F-fluorocyclobutanecarboxylic acid (anti-(18)F-FACBC) and (11)C-methyl-l-methionine ((11)C-Met), are suitable for detecting early responses to combination therapies including temozolomide (TMZ), interferon-β (IFN), and bevacizumab (Bev) in glioblastoma.

Methods: Human glioblastoma U87MG (U87) cells were incubated with low dose TMZ to induce chemoresistance. Both trans-1-amino-3-fluoro-1-(14)C-cyclobutanecarboxylic acid (anti-(14)C-FACBC) and (3)H-methyl-l-methionine ((3)H-Met) uptake were quantified using triple-label accumulation assays to examine the relationship between tracer uptake and proliferation ((3)H-thymidine (TdR) accumulation) in vitro.

Enhancement of optical Faraday effect of nonanuclear Tb(III) complexes.

The effective magneto-optical properties of novel nonanuclear Tb(III) complexes with Tb-O lattice (specifically, [Tb9(sal-R)16(μ-OH)10](+)NO3(-), where sal-R = alkyl salicylate (R = -CH3 (Me), -C2H5 (Et), -C3H7 (Pr), or -C4H9 (Bu)) are reported. The geometrical structures of these nonanuclear Tb(III) complexes were characterized using X-ray single-crystal analysis and shape-measure calculation. Optical Faraday rotation was observed in nonanuclear Tb(III) complexes in the visible region.

Comparison of trans-1-amino-3-[18F]fluorocyclobutanecarboxylic acid (anti-[18F]FACBC) accumulation in lymph node prostate cancer metastasis and lymphadenitis in rats.

Introduction: Trans-1-amino-3-[(18)F]fluorocyclobutanecarboxylic acid (anti-[(18)F]FACBC) is a positron emission tomography (PET) tracer used to visualize prostate cancer (PCa). In this study, we investigated the differences in anti-[(18)F]FACBC accumulation between metastatic and inflamed lymph node (LN) lesions.

Methods: A PCa LN metastasis (PLM) model was developed by inoculating a rat PCa cell line, MAT-Ly-Lu-B2, into popliteal LNs of Copenhagen rats.

Trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid (anti-18F-FACBC) is a feasible alternative to 11C-methyl-L-methionine and magnetic resonance imaging for monitoring treatment response in gliomas.

Introduction: Amino acid PET tracers are promising for visualizing gliomas and evaluating radiochemotherapeutic effects. We compared the glioma detection and early response assessment utility between trans-1-amino-3-fluoro-1-(14)C-cyclobutanecarboxylic acid (anti-(14)C-FACBC) and (3)H-methyl-l-methionine ((3)H-Met) by simultaneously analyzing their uptake by rat gliomas treated with and without temozolomide (TMZ) in vitro and in vivo.

Methods: C6 rat gliomas were incubated with low-dose TMZ to induce chemoresistance.

Effective optical Faraday rotations of semiconductor EuS nanocrystals with paramagnetic transition-metal ions.

Novel EuS nanocrystals containing paramagnetic Mn(II), Co(II), or Fe(II) ions have been reported as advanced semiconductor materials with effective optical rotation under a magnetic field, Faraday rotation. EuS nanocrystals with transition-metal ions, EuS:M nanocrystals, were prepared by the reduction of the Eu(III) dithiocarbamate complex tetraphenylphosphonium tetrakis(diethyldithiocarbamate)europium(III) with transition-metal complexes at 300 °C. The EuS:M nanocrystals thus prepared were characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), inductively coupled plasma atomic emission spectroanalysis (ICP-AES), and a superconducting quantum interference device (SQUID) magnetometer.

Magnetic and neutron diffraction study on melilite-type oxides Sr2MGe2O7 (M = Mn, Co).

The crystal structures and magnetic properties of melilite-type oxides Sr(2)MGe(2)O(7) (M = Mn, Co) were investigated. These compounds crystallize in the melilite structure with space group P ̅42(1)m, in which the M and Ge ions occupy two kinds of tetrahedral sites in an ordered manner. The magnetic M ions form a square-planar lattice in the ab plane.

Crystal structures and magnetic properties of new europium melilites Eu(2)MSi(2)O(7) (M = Mg, Mn) and their strontium analogues.

Synthesis, crystal structures, and magnetic properties of melilite-type oxides A(2)MSi(2)O(7) (A = Sr, Eu; M = Mg, Mn) were investigated. These compounds crystallize in the melilite structure with space group P4̅2(1)m. The (151)Eu Mössbauer measurements show that the Eu ions are in the divalent state.

Quantitative (19)F imaging of nmol-level F-nucleotides/-sides from 5-FU with T(2) mapping in mice at 9.4T.

A unique acquisition method is proposed for quantitative, high-sensitivity (19)F MR spectroscopic imaging for the study of drug distribution aiming at nmol-level metabolite information in mice. The use of fast spin echo (FSE) at 9.4T allowed us to obtain whole-body images with minimal effect of magnetic susceptibility and to acquire several metabolite signals simultaneously by the method of interleaved multifrequency selection.

Crystal structures and characterizations of mixed valence 12 L-perovskites Ba(4)EuM(3)O(12) (M = Ru and Ir).

The crystal structures and characterizations of Ba(4)EuM(3)O(12) (M = Ru and Ir) are reported. They crystallize in a monoclinic 12-l-perovskite-type structure with space group C2/m. The M(3)O(12) trimers and EuO(6) octahedra are alternately linked by corner-sharing and form the perovskite-type structure with 12 layers.

Magnetic and neutron diffraction study on quaternary oxides MTeMoO(6) (M = Mn and Zn).

Crystal structures and magnetic properties of quaternary oxides MTeMoO(6) (M = Mn and Zn) were investigated. From the Rietveld analyses for the powder x-ray and neutron diffraction measurements, their detailed structures have been determined. Both compounds have orthorhombic structure with space group P 2(1)2(1)2 and a charge configuration of M(2+)Te(4+)Mo(6+)O(6).