Synopsis of recent research by authors named "Yoshihiko Sakaguchi"
- Yoshihiko Sakaguchi's recent research focuses on exploring the molecular mechanisms underlying various health disorders, particularly metabolic liver diseases and cancer, by investigating cellular and microbial interactions in the liver and the tumor microenvironment.
- Key findings include the demonstration that Mac2-binding protein (M2BP) expression in the liver is affected by fibrosis and inflammation in metabolic dysfunction-associated steatotic liver disease, and the elucidation of the role of lysyl oxidase-like 4 (LOXL4) in promoting tumor invasiveness in triple-negative breast cancer through specific cellular interactions.
- Additionally, Sakaguchi's work examines the impact of microbial communities on liver disease progression and evaluates treatment outcomes for conditions such as hepatocellular carcinoma and recurrent Clostridioides difficile infections, revealing critical insights on the intersection of microbiome health and chronic diseases.
