Publications by authors named "Yoshihiko Nokura"
Article Synopsis
- Recent interest in marine cyanobacteria natural products, particularly aplysiatoxin (ATX) and oscillatoxin (OTX), has increased due to the discovery of new analogues with interesting biological activities.
- The study proposes that ATX can be a common biosynthetic precursor to synthesize five different analogues, revealing unique reactivities in its core structure.
- The successful synthesis of these analogues, including modifications and new lactones, led to revisions in the configuration of certain compounds, showcasing the versatility of ATX as an intermediate.
Total synthesis and biological evaluation of oscillatoxins D, E, and F.
Biosci Biotechnol Biochem
May 2021
Oscillatoxins (OTXs) and aplysiatoxins are biosynthetically related polyketides produced by marine cyanobacteria. We previously developed a synthetic route to phenolic O-methyl analogs of OTX-D and 30-methyl-OTX-D during collective synthesis of these natural products. According to our synthetic strategy, we achieved total synthesis of OTX-D, 30-methyl-OTX-D, OTX-E, and OTX-F by deprotecting the O-methyl group in an earlier intermediate, and determined their biological activities.
View Article and Find Full Text PDFO-Methyloscillatoxin D and its analogues were concisely synthesized by a bioinspired intramolecular Mukaiyama aldol reaction as a key step, which involves the construction of a novel spiro-ether moiety.
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