Publications by authors named "Yoshihiko Maeyama"
Objectives: To characterise the genotypic profiles of methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates from companion animals and to investigate their association with those from humans in Japan.
Methods: Non-duplicated MRSA clinical isolates recovered between July 2016 and January 2018 were analysed. The MRSA isolates were typed by polymerase chain reaction (PCR)-based open reading frame (ORF) typing (POT) scores, SCCmec types, multilocus sequence typing, and virulence gene profiles.
Article Synopsis
- Over a 35-month study in Japan, group B Streptococcus (GBS) with reduced penicillin susceptibility (PRGBS) was observed in elderly patients, with changes in serotype prevalence over time.
- Initially, serotype III was the most common, followed by a brief appearance of serotype Ib, and a shift to serotype Ia, which later re-emerged alongside serotype III.
- Genetic analysis revealed shared mutations in penicillin-binding proteins among the isolates, and whole-genome sequencing indicated closer genetic similarity between certain serotypes, suggesting potential capsular switching and transmission dynamics affecting serotype variation.
In recent years, besides the widespread occurrence of extended-spectrum β-lactamase (ESBL)- and/or plasmid-mediated AmpC (pAmpC)-producing Enterobacteriaceae in both healthcare and community settings of humans, the third-generation cephalosporin (3GC)-resistant microbes have also been reported from companion animals worldwide. Here, we characterized ESBL- and/or pAmpC-producing Enterobacteriaceae clinical isolates from companion animals. Among the 487 clinical isolates mainly from urine of dogs and cats between May and September 2016, 104 non-repetitive isolates were resistant to the 3GC, and they consisted of 81 of 381 (21.
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