Publications by authors named "Yoshihiko Itoh"
Masked CKD in hyperthyroidism and reversible CKD status in hypothyroidism.
Front Endocrinol (Lausanne)
November 2022
Introduction: While it is well known that thyroid function may affect kidney function, the transition of the chronic kidney disease (CKD) status before and after treatment for thyroid disorders, as well as the factors affecting this change, remains to be explored. In the present study, we focused on the change in kidney function and their affecting factors during the treatment for both hyperthyroidism and hypothyroidism.
Methods: Eighty-eight patients with hyperthyroidism and fifty-two patients with hypothyroidism were enrolled in a retrospective and longitudinal case series to analyze the changes in kidney function and their affecting factors after treatment for thyroid disorders.
Article Synopsis
- Pheochromocytomas and paragangliomas (PPGLs) are categorized into three types based on specific driver genes, with the Wnt-altered subtype being particularly aggressive and linked to gene fusions and mutations that overstimulate Wnt-β-catenin signaling.
- Wnt3a treatment in rat PC12 cells led to increased cell growth and decreased production of tyrosine hydroxylase, indicating that Wnt signaling negatively affects catecholamine biosynthesis and secretion.
- Inhibiting Wnt signaling using substances like XAV939 or sclerostin reduced cell proliferation and increased tyrosine hydroxylase levels, suggesting that enhanced Wnt-β-catenin signaling
Background And Objective: Lansoprazole is extensively metabolised by cytochrome P450 (CYP) 2C19 and CYP3A4. The purpose of this study was to evaluate the effects of CYP3A5 polymorphism (A6986G) on the pharmacokinetics of lansoprazole enantiomers in renal transplant recipients who are CYP2C19 extensive metabolisers (EMs).
Methods: Among 40 Japanese CYP2C19 EMs, 20 had the CYP3A5*1 allele (*1/*1 in two subjects and *1/*3 in 18 subjects) and 20 had the CYP3A5*3/*3 genotype.