- The study explores the "atopic march," which refers to the development of allergic conditions in infants and children, specifically examining how blood eosinophil-derived neurotoxin (EDN) relates to later allergic airway diseases like asthma and allergic rhinitis.
- Researchers enrolled 123 children under one year old, measuring their EDN levels and immunoglobulin E over three years, finding significant differences in EDN levels between those who developed allergic airway disease and those who did not, especially at ages 2 and 3.
- The results suggest that higher EDN levels during the early stages of food allergy or atopic dermatitis predict a greater likelihood of developing allergic airway diseases in young children, indicating the role of increased
Buckwheat can cause a rare condition called food protein-induced enterocolitis syndrome (FPIES), and this study focuses on a 4-year-old girl diagnosed with it.
Standard allergy tests for IgE were negative, but a lymphocyte stimulation test showed significant activation in response to buckwheat.
During an oral food challenge with buckwheat noodles, the patient experienced vomiting, confirming the diagnosis, and her lab results indicated inflammation, which might help in diagnosing similar non-IgE-mediated food allergies in the future.