Dibutyltin dichloride modifies amylase release from isolated rat pancreatic acini.

Introduction: Dibutyltin dichloride (DBTC) is widely used as a stabilizer for polyvinylchloride plastics and is of particular toxicologic interest.

Aim: To examine the effects of DBTC on pancreatic exocrine function in isolated rat pancreatic acini.

Methodology: Isolated rat pancreatic acini were incubated with various secretagogues in the presence or absence of DBTC.

Stimulatory effects of bilirubin on amylase release from isolated rat pancreatic acini.

Considered to be an etiologic factor of acute pancreatitis, hypersecretion of pancreatic juice and digestive enzymes is often associated with hyperbilirubinemia. We explored the intracellular mechanisms through which bilirubin affects pancreatic exocrine secretory function by examining the effect of bilirubin on isolated rat pancreatic acini. Bilirubin stimulated amylase release in a concentration- and time-dependent manner, significantly increasing amylase release at concentrations >5 mg/100 ml and after 15 min of incubation.