CORRIGENDUM: Deterioration of Phosphate Homeostasis Is a Trigger for Cardiac Afterload - Clinical Importance of Fibroblast Growth Factor 23 for Accelerated Aging.

[This corrects the article DOI: 10.1253/circrep.CR-22-0124.

Deterioration of Phosphate Homeostasis Is a Trigger for Cardiac Afterload - Clinical Importance of Fibroblast Growth Factor 23 for Accelerated Aging.

After the discovery of the Klotho gene, phosphate came into focus as a pathogenetic aging agent. Phosphate homeostasis is controlled by phosphate-regulating hormones: fibroblast growth factor 23 (FGF23), vitamin D, and parathyroid hormone. This study investigated the relationship between the deterioration in phosphate homeostasis and arterial stiffness by measuring serum FGF23 concentrations.

A simple method for accurate liver volume estimation by use of curve-fitting: a pilot study.

In this paper, we describe the effectiveness of our curve-fitting method by comparing liver volumes estimated by our new technique to volumes obtained with the standard manual contour-tracing method. Hepatic parenchymal-phase images of 13 patients were obtained with multi-detector CT scanners after intravenous bolus administration of 120-150 mL of contrast material (300 mgI/mL). The liver contours of all sections were traced manually by an abdominal radiologist, and the liver volume was computed by summing of the volumes inside the contours.

Increased urinary aldosterone excretion is associated with subcutaneous not visceral, adipose tissue area in obese individuals: a possible manifestation of dysfunctional subcutaneous adipose tissue.

Background: Aldosterone is reported to be associated with obesity and is a risk factor for metabolic syndrome. Metabolic abnormalities are more strongly associated with visceral adipose tissue (VAT) than with subcutaneous adipose tissue (SAT).

Objective: We examined whether aldosterone is more closely associated with VAT area than with SAT area in obese individuals.

Coefficient factor for graft weight estimation from preoperative computed tomography volumetry in living donor liver transplantation.

In the clinical setting of living donor liver transplantation (LDLT), it is common to find a discrepancy between the graft volume estimated by preoperative computed tomography volumetry and the actual graft weight (AGW) measured on the back-table. In this study, we attempt to find the coefficient factor that correlates the estimated graft volume to the AGW. Whole livers explanted in 25 LDLT recipients (17 cirrhotic and 8 morphologically normal with familial amyloid polyneuropathy) were evaluated to compare cirrhotic livers and noncirrhotic normal livers.

Heat shock treatment with mild electrical stimulation safely reduced inflammatory markers in healthy male subjects.

Objective: Obesity induces chronic inflammation, which contributes to the development and progression of insulin resistance, diabetes and atherosclerosis. We have recently shown that induction of heat shock protein 72 by mild electric current and thermo (MET) treatment in mouse model of type 2 diabetes ameliorated glucose homeostasis and insulin resistance accompanied by reduced adiposity. For clinical application of MET, we confirmed its safety in healthy subjects.

Preoperative prediction of poorly differentiated components in small-sized hepatocellular carcinoma for safe local ablation therapy.

Background: Poorly differentiated hepatocellular carcinoma (HCC) has a malignant potential such as frequent microvascular invasion even if the tumor is smaller than 3 cm in diameter. The aim of this study was to clarify the preoperative predictors of poorly differentiated HCC for safe local ablation therapy.

Methods: Sixty-six patients underwent a hepatic resection for solitary small-sized HCC ( View Article and Find Full Text PDF

Radiation dose reduction in hepatic multidetector computed tomography with a novel adaptive noise reduction filter.

Purpose: The aim of this study was to optimize a novel adaptive noise reduction filter based on patient body weight and to investigate its utility for improving the image quality of low-dose hepatic computed tomography (CT) scans.

Materials And Methods: The tube current-time product was changed from 140 to 180 and from 60 to 100 mAs at standard- and low-dose CT, respectively, based on the body weights of 45 patients. Unenhanced and two-phase contrast-enhanced helical scans were obtained at the standard dose during the hepatic arterial and equilibrium phases.

Contrast injection protocols for coronary computed tomography angiography using a 64-detector scanner: comparison between patient weight-adjusted- and fixed iodine-dose protocols.

Objective: To compare patient-weight-adjusted and fixed iodine-dose protocols at coronary computed tomography angiography (CTA) using a 64-detector scanner and computer-assisted bolus tracking.

Materials And Methods: Approval from our institutional review board and patient prior informed consent were obtained before entering 60 patients with suspected coronary disease in this study. The patients were randomly assigned to one of 2 protocols.

Detection of early enhancement of hypervascular hepatocellular carcinoma using single breath-hold 3D pixel shift dynamic subtraction MDCT.

Objective: The objective of our study was to evaluate the effect of single breath-hold dynamic subtraction MDCT of the liver on the performance of radiologists in detecting focal enhancement during the hepatic arterial phase.

Subjects And Methods: This prospective study included 40 patients: 22 had hypervascular hepatocellular carcinoma (HCC), and 18 were without liver tumors. We obtained four-phase contrast-enhanced scans using a 16-MDCT unit.

Pancreas: patient body weight tailored contrast material injection protocol versus fixed dose protocol at dynamic CT.

Purpose: To prospectively compare the effect of a protocol with a fixed contrast material injection dose and one with a dose tailored to patient body weight on pancreatic enhancement at dynamic computed tomography (CT) of the pancreas.

Materials And Methods: This study was approved by the institutional review board, and patients gave informed consent. Seventy-eight patients suspected of having pancreatic tumor were randomly assigned to one of two protocols (39 patients in each protocol).

Positional lumbar imaging using a positional device in a horizontally open-configuration MR unit - initial experience.

Purpose: To evaluate whether positional MR images of the lumbar spine, obtained with a horizontally open-configuration MR unit, demonstrate positional changes of the dural sac, and to assess whether there are significant differences in positional changes between healthy volunteers and patients with chronic low back pain.

Materials And Methods: The study population consisted of 15 patients with chronic low back pain and 14 healthy volunteers. MR images were obtained using a horizontally open-configuration 0.

Optimal dose and injection duration (injection rate) of contrast material for depiction of hypervascular hepatocellular carcinomas by multidetector CT.

Purpose: The aim of this study was to investigate the optimal dose and injection duration of contrast material (CM) for depicting hypervascular hepatocellular carcinomas (HCCs) during the hepatic arterial phase with multidetector row computed tomography (CT).

Materials And Methods: The study population consisted of 71 patients with hypervascular HCCs. After unenhanced scans, the first (early arterial phase, or EAP), second (late arterial phase, or LAP), and third (equilibrium phase) scanning was started at 30, 43, and 180 s after injection of contrast material (CM).

Multidetector CT findings suggesting a perforation site in the gastrointestinal tract: analysis in surgically confirmed 155 patients.

Purpose: The aim of this study was to investigate how accurately we could diagnose the level of gastrointestinal (GI) tract perforation using multidetector computed tomography (MDCT).

Materials And Methods: We reviewed 155 patients with surgically confirmed GI tract perforation. MDCT scans were obtained with eight-detector CT; 5 mm thick axial images and 2.

Hypervascular hepatocellular carcinomas: bolus tracking with a 40-detector CT scanner to time arterial phase imaging.

Purpose: To evaluate prospectively bolus tracking to time hepatic arterial phase (HAP) imaging of hypervascular hepatocellular carcinomas (HCCs) with a 40-detector computed tomographic (CT) scanner.

Materials And Methods: This study received institutional review board approval; informed consent was obtained. The study included 192 patients (123 men, 69 women; mean age, 67.

Prediction of aortic peak enhancement in monophasic contrast injection protocols at multidetector CT: phantom and patient studies.

Purpose: The aim of this study was to investigate whether it is possible to predict aortic peak enhancement (APE) from the contrast dose and injection rate.

Materials And Methods: We first undertook an experimental study using a flow phantom that simulates the human circulation. We delivered 90-150 ml of iomeprol-350 at various injection rates and measured the APE values of the simulated aorta.

Lower tube voltage reduces contrast material and radiation doses on 16-MDCT aortography.

Objective: The purpose of our study was to compare aortic CT angiography performed at a low tube voltage and reduced dose of contrast material with standard-voltage, standard-contrast-dose CT angiography.

Subjects And Methods: We evaluated 74 patients for aortic disease on MDCT angiography (collimation, 16 x 1.5 mm; beam pitch, 0.

Mass screening for prostate cancer in patients with end-stage renal disease: a comparative study.

Objective: To determine the usefulness of prostate-specific antigen (PSA) screening for prostate cancer in patients with end-stage renal disease (ESRD), as although serum PSA is effective in the early detection of this cancer in the general population, there are few reports of its utility in patients with ESRD.

Patients And Methods: Blood samples were obtained for PSA screening from April 2002 to September 2003; 1250 men with ESRD aged >50 years were compared with 1007 healthy control men aged >55 years, all in Kumamoto Prefecture, Japan. All men with a serum PSA level of >4.

Ectopic cervical thymus in an infant.

We report a case of accessory cervical thymus presenting as a unilateral neck mass in a 2-month-old boy. Ultrasonography (US) showed a mass isoechogenic to muscle in the left neck. Computed tomography (CT) revealed a well-defined, mildly enhanced mass located anterior to the sternocleidomastoid muscle, anterolateral to the carotid sheath, and posterior to the submandibular gland.

Monitoring therapeutic responses of primary bone tumors by diffusion-weighted image: Initial results.

The purpose of our study was to investigate whether quantitative diffusion-weighted images (DWI) were useful for monitoring the therapeutic response of primary bone tumors. We encountered 18 osteogenic and Ewing sarcomas. Magnetic resonance (MR) images were performed in all patients before and after therapy.

Automated hepatic volumetry for living related liver transplantation at multisection CT.

Purpose: To prospectively compare in vivo hepatic automated volumetry with manual volumetry and measured liver volume.

Materials And Methods: The study was conducted in accordance with the guidelines of the Institutional Review Board of Kumamoto University (Japan). Patient informed consent was obtained.

Pulmonary nodules: estimation of malignancy at thin-section helical CT--effect of computer-aided diagnosis on performance of radiologists.

Purpose: To evaluate the effect of a computer-aided diagnosis (CAD) system on the diagnostic performance of radiologists for the estimation of the malignancy of pulmonary nodules on thin-section helical computed tomographic (CT) scans.

Materials And Methods: The institutional review board approved use of the CT database; informed specific study-related consent was waived. The institutional review board approved participation of radiologists; informed consent was obtained from all observers.

Simulation of aortic peak enhancement on MDCT using a contrast material flow phantom: feasibility study.

Objective: The objective of our study was to develop a flow phantom simulating aortic peak enhancement after the injection of contrast material on CT and to investigate the validity of the flow phantom by comparing the time-enhancement curves obtained for the flow phantom and humans.

Materials And Methods: We developed a flow phantom simulating the enhancement pattern of the aorta after the injection of contrast material. In protocols 1, 2, and 3 of the phantom study, 90, 102, and 150 mL of iohexol, respectively, was administered over 35 sec.

Improvement of low-contrast detectability in low-dose hepatic multidetector computed tomography using a novel adaptive filter: evaluation with a computer-simulated liver including tumors.

Purpose: The purpose of this study was to investigate how much radiation dose can be reduced without loss of low-contrast detectability with a newly developed adaptive noise reduction filter in hepatic multidetector computed tomography (MDCT) scans by using a computer-simulated liver phantom.

Materials And Methods: Simulated CT images, including liver and intrahepatic tumors, were mathematically constructed using a computer workstation to evaluate low-contrast detectability by the observer performance test. Milliampere second for construction of simulated images were 60, 80, 100, and 120 mAs (low dose) and 160 mAs (standard dose) at 120 kVp.