Publications by authors named "Yoshiharu Isobe"

Article Synopsis
  • There is currently no reliable imaging method to assess liver reserve before carbon-ion radiotherapy (CIRT) for liver tumors, making it crucial to estimate liver capacity post-treatment.
  • The study evaluated the effectiveness of Tc-galactosyl human serum albumin (Tc-GSA) scintigraphy in predicting residual liver function in patients undergoing CIRT by comparing pre-treatment and post-treatment values.
  • The results showed a significant linear relationship between estimated and actual liver reserve capacity after CIRT, indicating that Tc-GSA scintigraphy could be a valuable clinical tool for assessing liver health prior to treatment.
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Purpose: We previously proposed a calculation method using Clarkson integration to obtain the physical dose at the center of the spread-out Bragg peak (SOBP) for a treatment beam, the measurement point of which agrees with the isocenter [Tajiri et al. Med. Phys.

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Breast cancer is increasingly being detected at earlier stages, and partial breast irradiation for patients with low-risk-group tumor has come to be applied in the US and Europe as an alternative to whole-breast irradiation. Based on those experiences, some institutes have tried using particle beams for partial breast irradiation for postoperative or radical intent for early breast cancer, but technical difficulties have hindered its progress. The National Institute of Radiological Sciences has been preparing for carbon-ion radiotherapy (C-ion RT) with radical intent for stage I breast cancer since 2011, and we carried out the first treatment in April 2013.

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Purpose: In broad-beam carbon-ion radiotherapy performed using the heavy-ion medical accelerator in Chiba, the number of monitor units is determined by measuring the physical dose at the center of the spread-out Bragg peak (SOBP) for the treatment beam. The total measurement time increases as the number of treatment beams increases, which hinders the treatment of an increased number of patients. Hence, Kusano et al.

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The National Institute of Radiological Sciences (NIRS) has extensively studied carbon-ion radiotherapy at the Heavy-Ion Medical Accelerator in Chiba (HIMAC) with some positive outcomes, and has established its efficacy. Therefore, efforts to distribute the therapy to the general public should be made, for which it is essential to enable direct application of clinical and technological experiences obtained at NIRS. For widespread use, it is very important to reduce the cost through facility downsizing with minimal acceleration energy to deliver the HIMAC-equivalent clinical beams.

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