Publications by authors named "Yoshie Akimoto"
Article Synopsis
- Abnormal osteoclast generation and activity lead to bone diseases like rheumatoid arthritis, osteopetrosis, and osteoporosis, and understanding how to control these processes is crucial for treatment.
- In this study, researchers found that the enzyme Impdh2 plays a key role in promoting bone resorption and that its deletion in mice resulted in increased bone mass due to fewer osteoclasts.
- The study also revealed that inhibiting Impdh2 with a specific drug reduced osteoclast differentiation and highlighted Impdh2 as a potential new target for therapies aimed at bone-related diseases.
Article Synopsis
- BMS-582949 is a clinical p38α inhibitor that shows potential in reducing excessive bone resorption, a key issue in conditions like osteoporosis and rheumatoid arthritis.
- The drug inhibits osteoclast differentiation and activity through specific signaling pathways, particularly by targeting MAPKs and AKT, while not interfering with NF-κB.
- In preclinical studies, BMS-582949 prevents bone loss in mice by reducing both bone resorption and formation, suggesting its effectiveness for treating osteolytic diseases.
Background: Osteoclast plays an important role in maintaining the balance between bone anabolism and bone catabolism. The abnormality of osteoclast is closely related to osteolytic bone diseases such as osteoporosis, rheumatoid arthritis and tumor bone metastasis.
Purpose: We aim to search for natural compound that may suppress osteoclast formation and function.
Bone metastases caused by breast cancer pose a major challenge to the successful treatment of breast cancer patients. Many researchers have suggested that herbal medicines are extremely effective at preventing and treating cancer-associated osteolysis. Previous studies have revealed that Morusin (MOR) is cytotoxic to many cancer cells ex vivo.
View Article and Find Full Text PDFBackground/aim: As one of the common clinical diseases, fractures have many causes, mechanisms, healing and influencing factors; especially fracture healing is a long-term and complex process. Animal fracture models can simulate the various states of human fractures, and on this basis, the prevention, mechanism, and treatment of fractures can be studied to further guide clinical practice.
Materials And Methods: Here, we developed a novel and portable device to create a closed fracture model in mice.
Alternative splicing can produce transcripts that affect cancer development and thus shows potential for cancer diagnosis and treatment. However, intron retention (IR), a type of alternative splicing, has been studied less in cancer biology research. Here, we generated a pan-cancer IR landscape for more than 10,000 samples across 33 cancer types from The Cancer Genome Atlas (TCGA).
View Article and Find Full Text PDFHachimijiogan (HJG) and Bakumijiogan (BJG), two derivative prescriptions of Rokumijiogan (RJG), were selected to investigate their renoprotective potential in the 5/6 nephrectomized (5/6Nx) rat model. Rats were treated with HJG and BJG orally at 150 mg/kg body weight/day once daily for 10 weeks after resection of 5/6 of the renal volume, and their renoprotective effects were compared with 5/6Nx vehicle-treated and sham-operated control rats. Improvements in renal lesions, glomerulosclerosis, tubulointerstitial injury, and arteriosclerotic lesions estimated by histologic scoring indices in the HJG-treated group were compared with those in the BJG-treated group.
View Article and Find Full Text PDFBackground: Some women with depressive disorders experience severe premenstrual symptoms. However, there have been few studies in which premenstrual symptoms in women suffering from depressive disorders were assessed. In this study, we aimed to investigate premenstrual symptoms in women with depressive disorders using the premenstrual dysphoric disorder (PMDD) scale.
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