Publications by authors named "Yoshiaki Yoshimura"
Postoperative adhesion around nerves sometimes results in sensory and motor dysfunctions. To prevent these disorders, we have developed an electrospun nanofiber sheet incorporating methylcobalamin (MeCbl), an active form of vitamin B12 with anti-inflammatory and neuroregenerative effects. This study aimed to investigate the neuroprotective effects of MeCbl sheets against postoperative adhesion and to compare the effects of MeCbl sheets with those of porcine small intestinal submucosa (SIS) sheets using a rat sciatic nerve adhesion model.
View Article and Find Full Text PDFArticle Synopsis
- Peripheral nerve injuries are common with serious consequences, and this study investigates the potential benefits of Neurotropin® (NTP) on nerve regeneration.
- The study utilized various methods, including in vitro tests on DRG neurons and an in vivo rat model of sciatic nerve injury, to assess the effects of NTP on nerve recovery.
- Results indicated that NTP enhances axonal outgrowth and significantly improves motor and sensory functions after injury, suggesting its dual role in pain relief and promoting peripheral nerve regeneration.