The effect of systemic anti-tumor necrosis factor-alpha treatment on Porphyromonas gingivalis infection in type 2 diabetic mice.

Objective: Diabetes mellitus and periodontal disease are two common chronic diseases that have long been thought to be biologically linked. Overexpression of tumor necrosis factor alpha (TNF-alpha) is thought to contribute to this bidirectional inter-relationship. This study examined the effect of anti-TNF-alpha antibody treatment on Porphyromonas gingivalis infection in diabetic mice.

Removal of infected nonresorbable hydroxyapatite graft material in recurrent periodontitis: a report of two cases.

Long-term studies have indicated that alloplastic bone grafts composed of nonresorbable hydroxyapatite (NHA) are clinically stable and safe. However, our previous report suggested that NHA grafts may be an etiological factor for recurrent periodontitis in the absence of supportive periodontal treatment (SPT). We removed infected NHA from the root surface by flap surgery in two cases of recurrent periodontitis.

Effects of marrow penetration on bone augmentation within a titanium cap in rabbit calvarium.

Background: Some studies have advocated marrow penetration in guided bone augmentation (GBA), whereas others have shown that bone can be generated without marrow penetration. This study examined the effect of marrow penetration and the optimal rate of penetration.

Methods: In 10 rabbits, the calvarium was exposed, and circular grooves were prepared bilaterally.