Predictive Utility of a Validated Polygenic Risk Score for Long-Term Risk of Coronary Heart Disease in Young and Middle-Aged Adults.

Background: Understanding the predictive utility of previously derived polygenic risk scores (PRSs) for long-term risk of coronary heart disease (CHD) and its additive value beyond traditional risk factors can inform prevention strategies.

Methods: Data from adults 20 to 59 years of age who were free of CHD from the FOS (Framingham Offspring Study) and the ARIC (Atherosclerosis Risk in Communities) study were analyzed. Because the PRS was derived from samples of predominantly European ancestry, individuals who self-reported White race were included.

Inappropriate activation of pacemaker magnet response mode by CPAP masks.

Background: While electromagnetic interference is widely recognized as a cause of noise detected by cardiac implanted electronic devices (CIEDs), we report on two cases of inappropriate activation of magnet response mode due to magnets in continuous positive airway pressure (CPAP) masks.

Methods: Two patients with St. Jude Medical dual-chamber pacemakers (Assurity DR 2240; St.

Selective implantation of durable left ventricular assist devices as primary therapy for refractory cardiogenic shock.

Objective: Surgical therapy for refractory primary cardiogenic shock is largely based on emergent placement of extracorporeal membrane oxygenation or short-term ventricular assist devices. We have adopted a strategy of routine implantation of durable left ventricular assist devices (LVAD) as initial therapy for refractory cardiogenic shock, in patients who are potential candidates for heart transplantation, and report our experience.

Methods: Retrospective review of 43 consecutive patients with refractory shock caused by acute myocardial infarction (n = 21) or acute decompensated heart failure (n = 22) who were treated with primary implantation of a durable LVAD in a single institution.

Nontraumatic ascending aortic disruption.

This report documents a case of completely spontaneous ascending aortic disruption. A 54-year-old African American male day laborer presented with severe retro-sternal chest and back pain and shortness of breath. He had no history of hypertension, smoking, or trauma and was taking no medications.