Publications by authors named "Yorkiris Marmol Contreras"
Article Synopsis
- Frustrative nonreward (FNR) is an emotional response triggered by the lack of essential resources (like food or social interaction), affecting behaviors and physical health.
- FNR plays a role in various issues like irritability, aggression, motivation disorders, and social behavior, suggesting it’s important for understanding mental health.
- Recent interest in FNR has increased due to the COVID-19 pandemic, which heightened its effects, leading to more research on animal models and brain mechanisms linked to psychiatric disorders.
In humans, frustrating experiences are known to trigger relapse events and individuals with higher frustration intolerance show increased risk of developing substance use disorders (SUDs). Despite this clear relationship, frustration-related behavior is seldom studied concurrently with self-administration behavior in rodent models. A major obstacle has been the lack of robust, quantitative assays of frustration-related operant behavior thus far.
View Article and Find Full Text PDFRationale: Currently there is little research into the role of frustration in substance use disorders despite research showing that frustration tolerance in humans is associated with a lower likelihood of developing substance use problems, better outcomes in recovery, and fewer relapses.
Objective: In order to address this need, our studies use a rat model to focus on frustration-related behavior in natural reward and addiction-related behavioral procedures. Frustration is defined as when a subject is unable to achieve a reinforcer, receives less of a reinforcer than anticipated, or has to work harder to achieve a reinforcer.