Publications by authors named "Yordi Tarazona-Castro"
Article Synopsis
- Scientists are still trying to understand the impact of COVID-19 clinical biomarkers, which are indicators of the disease's progression and severity.
- A study in Lima and Huaraz (two Peruvian cities at different altitudes) compared COVID-19 patients in ICUs, those hospitalized but not in ICUs, and healthy controls, checking levels of five specific biomarkers.
- Results showed higher levels of ferritin, C-reactive protein, and IL-6 in both patient groups at both locations, with unique findings for hepcidin and zinc, indicating that high-altitude patients have distinct biomarker profiles compared to those at lower altitudes.
(1) Background: Human fascioliasis is considered an endemic and hyper-endemic disease in the Peruvian Andean valleys. Our objective was to determine variations in the composition of the gut microbiota among children with and children who do not have this parasitosis. (2) Method: A secondary analysis was performed using fecal samples stored in our biobank.
View Article and Find Full Text PDFBackground: The Chikungunya virus (CHIKV) is an emerging arthropod-borne virus (arbovirus) that causes undifferentiated acute febrile illness. Cases of CHIKV may be under-reported in Peru, given the various difficulties in diagnosing it, such as lack of diagnostic tests in remote areas, the passive nature of epidemiological surveillance, and co-circulation of other arthropod-borne pathogens. Therefore, a study was conducted in the high jungle of northern Peru to determine the prevalence of CHIKV among febrile patients and describe their clinical characteristics.
View Article and Find Full Text PDFIntroduction: Human rhinovirus is a major cause of acute respiratory infections (ARIs) worldwide. Epidemiological data on human rhinovirus (RV) in Peru is still scarce, as well as its role in respiratory infections in children. Therefore, the aim of this study was to describe the prevalence of rhinovirus and to identify the circulating species in nasopharyngeal swabs from children with acute respiratory infections.
View Article and Find Full Text PDFArticle Synopsis
- * A total of 464 febrile patients were analyzed, with over 40% testing positive for one pathogen; the most common was SARS-CoV-2 IgM (73.40%), while co-infections primarily involved DENV and SARS-CoV-2.
- * Findings suggest that SARS-CoV-2 should be considered in acute febrile illness cases in regions where arboviral diseases are common, highlighting the potential for co-infections and the need for
Article Synopsis
- A study conducted in Peru compared inflammatory responses in COVID-19 patients living at different altitudes (Lima vs. Huaraz) to understand how altitude affects inflammation.
- Results showed significantly higher levels of proinflammatory cytokines IL-6 and TNF-α in COVID-19 patients from Huaraz (high altitude) compared to those from Lima (sea level).
- The findings suggest that altitude may influence inflammation in COVID-19, indicating a need for further research to deepen understanding and improve treatment strategies.
Objective: This study was carried out to determine the prevalence of leptospirosis among febrile patients with a suspicious clinical diagnosis of dengue fever in northern Peru.
Results: A total of 276 serum samples from patients with acute febrile illness (AFI) and suspected diagnosis for dengue virus (DENV) were analyzed. We identified an etiological agent in 121 (47.
Article Synopsis
- The study aims to assess HPV prevalence and risk factors among Peruvian women using population-based screening.
- A total of 524 samples were tested, resulting in 100 HPV positive cases, predominantly high-risk types found in women aged 26-45.
- High-risk HPV was most frequently detected in married women and those with children, with a notable correlation between low abortion history and higher risk HPV prevalence.
Objective: To describe frequency and clinical characteristics of MAYV infection in Piura, as well as the association of this pathogen with DENV.
Results: A total of 86/496 (17.3%) cases of MAYV were detected, of which 54 were MAYV mono-infection and 32 were co-infection with DENV, accounting for 10.
Objective: To characterize the cervicovaginal microbiota of HPV-positive and HPV-negative asymptomatic Peruvian women, by identifying the presence of 13 representative bacteria genus.
Results: A total of 100 HPV-positive and 100 HPV-negative women were matched by age for comparison of microbiota. The following bacteria were more frequently identified in HPV-positive patients compared to HPV-negative: Eubacterium (68 vs 32%), Actinobacteria (46 vs 33%), Fusobacterium (11 vs 6%) and Bacteroides (20 vs 13%).
Unidentified dengue serotypes in DENV positive samples and detection of other pathogens responsible for an acute febrile illness outbreak 2016 in Cajamarca, Peru.
BMC Res Notes
October 2020
Objective: To describe the prevalence of dengue virus serotypes, as well as other viral and bacterial pathogens that cause acute febrile illness during an outbreak in Cajamarca in 2016.
Results: Dengue virus (DENV) was the most frequent etiologic agent detected in 25.8% of samples (32/124), followed by Rickettsia spp.