Publications by authors named "Yoosun Joo"

Article Synopsis
  • Interest in citrate-based dialysate (Cit-D) is increasing due to its advantages in anticoagulation and dialysis efficiency, yet research on its use in high-volume hemodiafiltration (HDF) is limited.
  • This study analyzed 28 patients who switched from acetate-based dialysate (Acet-D) to Cit-D, examining safety and effectiveness across three 12-week periods.
  • Results showed a 17% reduction in heparin dosage, improvements in dialysis efficiency (increased Kt/V and urea reduction ratio), and no significant safety concerns, suggesting Cit-D may have benefits over Acet-D in this setting.
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Background: Immediate-start peritoneal dialysis (ISPD) is an effective renal replacement therapy that can prevent central venous catheterization due to its immediate initiation of peritoneal dialysis (PD) after catheter insertion without a break-in period. This study aimed to investigate the effect of ISPD on long-term patient survival.

Methods: In this retrospective single-center cohort study, 178 consecutive patients who started PD from August 2005 to March 2023 were enrolled, from whom 144 patients with ISPD were analyzed.

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Dialysis patients are more likely to die or become hospitalized from coronavirus disease 2019 (COVID-19). Currently, only a few studies have evaluated the efficacy of a fourth booster vaccination in hemodialysis (HD) patients and there is not enough evidence to recommend for or against a fourth booster vaccination. This study compared the humoral response and disease severity of patients on HD who received either three or four doses of COVID-19 vaccine.

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Endogenous sphingolipids (ceramide) and related synthetic molecules (FTY720, SH-BC-893) reduce nutrient access by decreasing cell surface expression of a subset of nutrient transporter proteins. Here, we report that these sphingolipids disrupt endocytic recycling by inactivating the small GTPase ARF6. Consistent with reported roles for ARF6 in maintaining the tubular recycling endosome, MICAL-L1-positive tubules were lost from sphingolipid-treated cells.

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