Real-World Status in the Treatment of Latent Tuberculosis Infection in People Living with HIV in Korea.

This retrospective study analyzed medical records of 1,392 people living with HIV (PLWH) diagnosed with latent tuberculosis infection (LTBI) at two provincial central hospitals from 2011 to 2022. LTBI was diagnosed in 152 patients (10.9%) patients aged ≥18 years.

Effects of genetic mutations on left ventricular myocardial mechanics and fibrosis patterns in hypertrophic cardiomyopathy.

Myocyte disarray and fibrosis are underlying pathologies of hypertrophic cardiomyopathy (HCM) caused by genetic mutations. However, the extent of their contributions has not been extensively evaluated. In this study, we investigated the effects of genetic mutations on myofiber function and fibrosis patterns in HCM.

A Network Analysis of Quality of Life Among Older Adults With Arthritis.

Introduction: Arthritis, one of the most common chronic diseases among older people, greatly impairs quality of life through a variety of physical and psychological challenges. This study used network analysis to gain a deeper understanding of the relationships between the indicators of quality of life in older adults with arthritis depending on duration of disease.

Methods: This cross-sectional study used data from 874 older adults with osteoarthritis and/or rheumatoid arthritis who answered the eighth (2019-2021) Korea National Health and Nutrition Examination Survey.

Home visit-based baby tailored support program for infants.

Purpose: According to the annual developmental screening tests in South Korea, an increasing number of infants require further evaluation for the early assessment and treatment of developmental disabilities. We developed the Home Visit-Based Baby Tailored Support Program (H-BTS) and explored its potential effectiveness on infants' cognitive, language, and motor development, as well as their mothers' knowledge of infant development, parenting anxiety, and parenting efficacy.

Methods: We employed a non-equivalent control group pretest-posttest design with 49 infants and mothers in Seoul, Korea.

Exploring structural and biological insights of TEAD through rational design and synthesis of niflumic acid derivatives.

Transcriptional enhanced associate domain (TEAD) transcription factors undergo auto-palmitoylation, which is critical to mediate their function and maintain stability. Targeting the palmitate binding pocket of TEAD holds considerable promise for drug discovery, and it can be characterised into three components: a conserved cysteine, a hydrophobic main pocket, and a hydrophilic side pocket. Endogenous palmitate and several known TEAD inhibitors interact with the cysteine and hydrophobic residues in the deep hydrophobic pocket.

Factors Associated With Health-Promoting Behaviors Among South Korean Adults: A Cross-Sectional Study.

Objective: To examine the association between positive psychological capital, social support, illness attitudes toward COVID-19, and health-promoting behaviors in Korean adults.

Design: An online cross-sectional study.

Sample: The participants were 820 South Korean adults aged 19-64, recruited through quota sampling.

Childhood Emotional Trauma and Flourishing in Female College Students.

There are few studies that measure the effects of childhood emotional trauma on female college students' positive perceptions and attitudes toward their present lives. Therefore, this study analyzes how female college students' emotional trauma induced by child emotional abuse influences their flourishing as adults. To this end, a descriptive survey via an online platform was conducted from November 26 to December 3, 2022.

Discovery of organosulfur-based selective HDAC8 inhibitors with anti-neuroblastoma activity.

Histone deacetylases (HDACs) are important epigenetic regulators of gene expression and various cellular processes, and are potential targets for anticancer therapy. In particular, HDAC8 is a promising therapeutic target for childhood neuroblastoma. To date, five HDAC inhibitors have been approved as anticancer drugs; however, all are non-selective HDAC inhibitors with various side effects.

Associations Among Family Strengths, Depression and Life Satisfaction Between Disabled Children and Their Parent Caregivers: An Actor-Partner Interdependence Mediation Model.

Aim: To explore the actor-partner effect and mediating role of depression on family strength and life satisfaction among children with disabilities and their parent-caregiver dyads.

Design: A cross-sectional study using secondary data collected from the 2020 (third) Korea Disability and Life Dynamics Panel.

Methods: This study included 434 Korean dyads of children with disabilities and their parent caregivers.

The Effects of Workplace Spirituality and Self-Efficacy on Quality of Life Among Cancer Survivors: Empirical Quantitative Research.

Aims: To investigate the impact of workplace spirituality and self-efficacy (SE) on cancer survivors' quality of life (QOL) and develop nursing interventions.

Design: Descriptive survey.

Methods: Participants were cancer survivors treated at Chung-Ang hospital in Seoul.

Translation and psychometric evaluation of the Korean version of the Reproductive Concerns After Cancer Scale (RCAC).

Background: Improving cancer survival rates highlights post-treatment fertility implications for reproductive-aged women. To provide fertility care for cancer survivors, nurses need instruments to assess and communicate reproductive concerns with cancer survivors and healthcare providers. This study aimed to translate the Reproductive Concerns after Cancer Scale (RCAC) into Korean and examine its psychometric properties in young female cancer survivors in South Korea.

Nationwide Prevalence of Video Head Impulse Test Abnormality and its Risk Factors in South Korea.

Objective: To identify the prevalence of and relevant information for video head impulse test (vHIT) abnormality in a large population.

Study Design: A cross-sectional design.

Setting: Korean National Health and Nutrition Examination Survey, 2021.

Clinical Outcomes of Solid Organ Transplant Recipients Hospitalized with COVID-19: A Propensity Score-Matched Cohort Study.

Background: Solid-organ transplant recipients (SOTRs) receiving immunosuppressive therapy are expected to have worse clinical outcomes from coronavirus disease 2019 (COVID-19). However, published studies have shown mixed results, depending on adjustment for important confounders such as age, variants, and vaccination status.

Materials And Methods: We retrospectively collected the data on 7,327 patients hospitalized with COVID-19 from two tertiary hospitals with government-designated COVID-19 regional centers.

Effectiveness and Tolerability of Dual Therapy with Dolutegravir Plus Darunavir/cobicistat in Treatment-Experienced Patients with HIV: A 144-Week Follow-Up.

Background: A dual regimen with dolutegravir plus cobicistat-boosted darunavir (DTG+DRV/c) is a promising alternative for patients with human immunodeficiency virus (HIV) with resistance or intolerance to nucleoside reverse transcriptase inhibitors, especially those with a history of treatment failure.

Materials And Methods: We included all treatment-experienced patients with HIV who switched to the DTG+DRV/c regimen at a tertiary university hospital. We assessed the regimen's effectiveness, safety, and tolerability through serial laboratory data and clinical findings.

Synthesis and evaluation of antibody-drug conjugates with high drug-to-antibody ratio using dimaleimide-DM1 as a linker- payload.

The notable characteristics of recently emerged Antibody-Drug Conjugates (ADCs) encompass the targeting of Human Epidermal growth factor Receptor 2 (HER2) through monoclonal antibodies (mAbs) and a high ratio of drug to antibody (DAR). The achievements of Kadcyla® (T-DM1) and Enhertu® (T-Dxd) have demonstrated that HER2-targeting antibodies, such as trastuzumab, have shown to be competitive in terms of efficacy and price for development. Furthermore, with the arrival of T-Dxd and Trodelvy®, high-DAR (7-8) ADCs, which differ from the moderate DAR (3-4) ADCs that were formerly regarded as conventional, are being acknowledged for their worth.

Antimicrobial Use and Carbapenem-Resistant Enterobacterales in Korea: A Nationwide Case-Control Study With Propensity Score Matching.

Background: Nationwide research on the association between carbapenem-resistant (CREs) and antibiotic use is limited.

Methods: This nested case-control study analyzed Korean National Health Insurance claims data from April 2017 to April 2019. Based on the occurrence of CRE, hospitalized patients aged ≥ 18 years were classified into CRE (cases) and control groups.

Effect of Regdanvimab on Mortality in Patients Infected with SARS-CoV-2 Delta Variants: A Propensity Score-Matched Cohort Study.

Introduction: Regdanvimab, a monoclonal antibody pharmaceutical, is the first Korean drug approved for treating coronavirus disease 2019 (COVID-19). We analyzed the therapeutic efficacy of regdanvimab in patients with the COVID-19 delta variant infection.

Methods: We retrospectively reviewed the electronic medical records of patients hospitalized at two Korean tertiary COVID-19 hospitals with COVID-19 delta variant infection between May 26, 2021, and January 30, 2022.

Development of a multiplex droplet digital PCR method for detection and monitoring of Mycobacterium tuberculosis and drug-resistant tuberculosis.

Background: The prevalence of multidrug-resistant tuberculosis (MDR-TB) among Korean tuberculosis patients is about 4.1%, which is higher than the OECD average of 2.6%.

Development and validation of cardiac diffusion weighted magnetic resonance imaging for the diagnosis of myocardial injury in small animal models.

Cardiac diffusion weighted-magnetic resonance imaging (DWI) has slowly developed due to its technical difficulties. However, this limitation could be overcome by advanced techniques, including a stimulated echo technique and a gradient moment nulling technique. This study aimed to develop and validate a high-order DWI sequence, using echo-planar imaging (EPI) and second-order motion-compensated (M012) diffusion gradient applied to cardiac imaging in small-sized animals with fast heart and respiratory rates, and to investigate the feasibility of cardiac DWI, diagnosing acute myocardial injury in isoproterenol-induced myocardial injury rat models.

Nursing students' clinical practice education experience during the COVID-19 pandemic: a qualitative study.

Background: Nursing education, including some elements of clinical practice, has largely been conducted online during the coronavirus disease 2019 (COVID-19) pandemic. Numerous studies have examined the experiences of nursing students in academia during the pandemic. However, research on nursing students' clinical practice experiences is limited.