Publications by authors named "Yoon-Kyeong Oh"
Article Synopsis
- This study compared initial and follow-up brain treatments and overall survival for breast cancer patients with different numbers of brain metastases (1-4 vs 5-10).
- It found that patients with 1-4 brain metastases were more likely to receive stereotactic radiosurgery (SRS) while those with 5-10 mostly underwent whole-brain radiotherapy (WBRT), leading to varying overall survival rates.
- The choice of initial treatment depended on factors such as the number and location of metastases and overall patient health, but neither the number of metastases nor WBRT directly affected survival; instead, SRS/FSRT as a salvage treatment improved survival outcomes significantly.
Purpose: We previously constructed a nomogram for predicting the risk of arm lymphedema following contemporary breast cancer treatment. This nomogram should be validated in patients with different background characteristics before use. Therefore, we aimed to externally validate the nomogram in a large multi-institutional cohort.
View Article and Find Full Text PDFPurpose: We aimed to investigate manifestations and patterns of care for patients with brain metastasis (BM) from breast cancer (BC) and compared their overall survival (OS) from 2005 through 2014 in Korea.
Materials And Methods: We retrospectively reviewed 600 BC patients with BM diagnosed between 2005 and 2014. The median follow-up duration was 12.
Article Synopsis
- The study aimed to identify risk factors for new brain metastases (BM) in breast cancer patients after initial brain-directed treatment.
- Of 538 patients analyzed, 37.4% developed new BM, with rates varying by molecular subtype: HR+/HER2- (51.9%), HER2+ (44.0%), and TNBC (69.6%).
- Factors increasing the risk of new BM included short intervals between primary diagnosis and BM, the presence of extracranial metastases, and having more than four BMs, while whole-brain radiotherapy (WBRT) and anti-HER2 therapy significantly reduced new BM occurrences.
Purpose: This study evaluated the influence of prognostic factors and whole brain radiotherapy (WBRT) on overall survival (OS) of breast cancer (BC) patients with brain metastases (BM).
Methods And Materials: Medical records of 730 BC patients diagnosed with BM from 2000 to 2014 at 17 institutions were retrospectively reviewed. OS was calculated from BM diagnosis.
Endocrine therapies, which inhibit estrogen receptor signaling, are the most common and effective treatments for estrogen receptoralpha-positive breast cancer. However, the utility of these agents is limited by the frequent development of resistance, and the precise mechanisms underlying endocrine therapy resistance remain incompletely understood. Here, we demonstrate that peptidyl-prolyl isomerase Pin1 is an important determinant of resistance to tamoxifen and show that Pin1 increases E2F-4- and Egr-1-driven expression of LC-3 as a result of an increased interaction with and phosphorylation of MEK1/2.
View Article and Find Full Text PDFThis study investigated radioresistance mechanisms in the doxorubicin-resistant acute myelogenous leukemia (AML)-2/DX100. AML-2/DX100 also showed resistance to radiation. AML-2/DX100 characterized by down-regulated catalase expression was supersensitive to exogenous hydrogen peroxide whereas they increased defense mechanisms against endogenous reactive oxygen species (ROS) as compared with AML-2/WT.
View Article and Find Full Text PDFPurpose: Breast-conserving therapy (BCT) is a practical alternative to mastectomy for treating ductal carcinoma in situ (DCIS). We reviewed our experience for treating patients with DCIS of the breast to evaluate the outcome after performing breast-conserving surgery plus radiotherapy (BCS-RT).
Materials And Methods: Between January 1983 and December 2002, 25 patients with clinically or mammographically detected DCIS were treated by BCS-RT.
Anti-oxidant adaptation in the AML cells supersensitive to hydrogen peroxide.
Biochem Biophys Res Commun
June 2004
The purpose of this study was to investigate the adaptive mechanisms of hydrogen peroxide-supersensitive AML cells against the reactive oxygen species (ROS). Their scavenging capacity against ROS was determined using a fluorometric probe in the doxorubicin-resistant AML-2/DX100 cell characterized by the down-regulation of catalase. AML-2/DX100 cells had more scavenging capacity against endogenous pro-oxidants than did the parental cells AML-2/WT, suggesting that an anti-oxidant adaptation against ROS occurred.
View Article and Find Full Text PDFPurpose: To evaluate the role of curative radiotherapy alone in the treatment of uterine cervical carcinomas, by a retrospective analysis with respects to survival and pelvic control, and to find any risk factors of failure.
Materials And Methods: Between Jan. 1990 and Dec.