Publications by authors named "Yoon-Ju Bae"
Article Synopsis
- - The study investigates the potential of larvae powder as an alternative protein source for livestock, particularly in the context of its digestibility when ingested with expanded polystyrene (EPS), which larvae can break down.
- - Toxicity tests were conducted using both cell cultures and male rats to assess the effects of larvae powder on health parameters, revealing no significant harmful effects associated with the larvae mixed with EPS.
- - The findings suggest that larvae powder is safe for consumption by livestock and can serve as a valuable protein source, although more extensive research is needed across different animal species and both genders.
Article Synopsis
- Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) shows lower aldosterone levels compared to immunoassays and specific cutoff values for diagnosing primary aldosteronism (PA) are lacking.
- In a study of 104 patients suspected of PA, proposed LC-MS/MS-specific cutoff values for the saline infusion test demonstrated better diagnostic accuracy than traditional immunoassay values.
- The most effective LC-MS/MS cutoff value identified was 83 pmol/L, leading to high sensitivity (96.9%) and specificity (92.5%), highlighting the need for updated cutoff values in PA diagnosis.
Article Synopsis
- Marathon running significantly affects the levels of nine steroid hormones, including aldosterone, progesterone, and cortisol, which increase sharply after the race.
- Blood samples were collected from 60 male participants of the Berlin marathon at three different times to analyze these hormone changes using advanced mass spectrometry.
- The study found that higher increases in aldosterone and progesterone were linked to marathon performance and were influenced by factors such as body mass index, training distance, and age.
Article Synopsis
- Electro-anatomical remodeling in atrial fibrillation (AF) affects its development and progression, with Troponin T (TropT) being a key biomarker linked to AF incidence but underexplored in its role in AF progression.* -
- The study analyzed 241 AF patients undergoing ablation and compared them with 824 healthy individuals, finding higher TropT levels and larger left atrium sizes in AF patients, indicating a strong association with AF progression phenotypes like persistent AF and left atrial low voltage areas (LVAs).* -
- TropT levels varied significantly across different AF progression groups, suggesting that TropT could serve as a predictive marker for LVAs, enhancing the understanding of AF progression and aiding
Article Synopsis
- A study investigated the relationship between anxiety, obesity, and sex hormones in a cohort of 3,124 adult women, focusing on both premenopausal and postmenopausal groups.
- Results indicated that there were no significant differences in anxiety levels between obese and normal-weight premenopausal women, and both conditions were linked to elevated testosterone levels.
- The findings revealed opposing effects of anxiety and obesity on estradiol levels in premenopausal women, but ultimately suggested that sex hormone changes related to obesity do not significantly impact anxiety symptoms.
Article Synopsis
- A new analytical method (LC-MS/MS) for measuring nine steroid hormones was developed, necessitating the establishment of new reference intervals spanning from infancy to old age (0.3 to 79 years).
- The study analyzed serum samples from 4,678 individuals, considering factors like sex, age, and pubertal stage while excluding those with certain health conditions and high body mass index.
- Results highlighted hormonal changes throughout life, such as a surge in androgens and estrogens during early infancy and variations during puberty, with increased cortisol levels under oral contraceptives, ultimately aiding routine diagnostics in clinical settings.
Article Synopsis
- Research shows a connection between depression and being overweight in women, particularly focusing on the role of sex hormones in this relationship.
- The study analyzed data from 3,124 women, finding that being overweight is linked to higher depressive symptoms in premenopausal but not postmenopausal women.
- High free testosterone levels were associated with both being overweight and depressive symptoms in premenopausal women, suggesting targeted hormonal treatments could be beneficial for those who don't respond to traditional antidepressants.
Article Synopsis
- - Acute stress triggers a broad physiological response that is beneficial when it starts and ends quickly, primarily controlled by the brain, which is also impacted by stress itself.
- - This study explored how stress affects whole-brain network topology, specifically focusing on stress reactivity and recovery using resting-state fMRI in healthy young males undergoing the Trier Social Stress Test.
- - Results showed significant changes in the thalamus, a central hub in the brain, which correlated with subjective stress levels and persisted even after the stress ended, highlighting its role in processing stress information.
Context: Steroid hormones are important regulators of physiological processes in humans and are under genetic control. A link to coronary artery disease (CAD) is supposed.
Objective: Our main objective was to identify genetic loci influencing steroid hormone levels.
Article Synopsis
- - The study focuses on establishing age- and gender-dependent serum reference ranges for calcitonin (CT) in a pediatric population to improve diagnostics for conditions like multiple endocrine neoplasia type 2 (MEN 2) and medullary thyroid carcinoma (MTC).
- - Researchers analyzed 6090 serum samples from 2639 children aged 1 month to 17.9 years, finding that boys had significantly higher CT levels, and observed a notable decline in CT from newborns to children aged 4 and 5.
- - The findings conclude that this study provides the largest set of pediatric reference ranges for CT and confirms minimal impact of thyroid diseases on CT levels in children, aiding in better clinical monitoring for MEN
Article Synopsis
- - The study focused on validating the Korean version of the Urticaria Control Test (K-UCT) to assess chronic urticaria (CU) control status and its link to stress hormones like salivary cortisol and cortisone.
- - After linguistic adaptation and testing on 96 CU patients, results showed strong reliability and correlations between K-UCT scores and measures of disease severity and quality of life.
- - The K-UCT may be an effective tool to evaluate CU control in Korean patients, with further research suggested to explore the potential of salivary cortisone as a biomarker for CU control.
Article Synopsis
- The study investigated how stress affects hormone levels, specifically looking at salivary cortisone's effectiveness as a stress biomarker during a standardized stress test.
- Healthy young men participated in tests where their hormonal responses and psychological states were measured through various methods including blood and saliva samples.
- Results showed that salivary cortisone had a strong correlation with self-reported anxiety and heart rate increases, suggesting it could be a reliable indicator of stress with potential implications for future research.
Article Synopsis
- The study aimed to explore the relationship between stress-related hormones and early signs of periodontal disease in adolescents aged 10 to 18 years, analyzing factors like probing depth and hormone levels.
- Researchers found significant associations between interleukin-6, body mass index (BMI), and positive aMMP-8 test results with signs of periodontal inflammation, but no significant links were found for cortisol and DHEA-S levels.
- The conclusion suggests that while DHEA-S and nutritional status (BMI) are related to early signs of periodontal disease, more research in high-risk groups is needed to validate these findings.
Article Synopsis
- Surgical procedures, both laparoscopic and conventional, induce stress responses in patients that can influence recovery outcomes, with this study focusing on stress biomarkers like copeptin and steroid hormones during colorectal surgery.* -
- Eleven patients experienced minimally invasive surgery while ten underwent conventional open surgery, and blood samples were analyzed at different surgery stages to measure stress-related biomarker responses.* -
- Results indicated that stress biomarkers, particularly cortisol and glucose, decreased more quickly to baseline levels after minimally invasive surgery compared to open surgery, suggesting a different stress response that may affect long-term recovery.*
Article Synopsis
- The review emphasizes the importance of vitamin D and calcium in human milk for infant growth and rickets prevention.
- It explores how vitamin D and calcium transfer into breast milk, along with recommended intake for infants and lactating mothers.
- The review also discusses the factors affecting vitamin D and calcium levels in breast milk and methods for measuring these nutrients.
Article Synopsis
- * Factors influencing adipokine concentrations in breast milk, such as maternal weight and milk pasteurization, are summarized, highlighting their importance in affecting breast milk composition.
- * The findings suggest that various sources contribute to the levels of adipokines in breast milk, which may be linked to infant weight gain and potential obesity risks later in life, indicating that early adipokine regulation could impact long-term health outcomes.
Increased estrogen level can be associated with depression in males.
Psychoneuroendocrinology
January 2018
Article Synopsis
- The study investigates the link between obesity, depression, and sex hormone levels in men, using data from the LIFE-Adult-Study involving nearly 4,000 participants divided by age.
- Results show that obese men had lower levels of total and free testosterone compared to normal-weight counterparts, with older obese men also exhibiting higher estradiol levels.
- Younger men with depressive symptoms had elevated estradiol levels, but there was no direct link between their BMI and depression symptoms.
Article Synopsis
- The study examined how stress affects children aged 8 to 14 with various psychiatric disorders compared to healthy controls, using the Trier Social Stress Test for Children.
- Researchers measured both the cortisol levels in saliva and children's subjective experiences of stress before and after the test, involving a sample of 170 children.
- Findings revealed that children with internalizing or externalizing disorders had lower cortisol responses and different perceptions of their performance and emotions compared to healthy peers, indicating a link between stress responses and psychiatric conditions.
Article Synopsis
- The study evaluated a new fully-automated Elecsys® Cortisol II assay for measuring cortisol levels in serum and saliva, which is important for diagnosing serious adrenal disorders like Cushing's and Addison's disease.
- The assay showed strong precision and reproducibility with low coefficients of variation and closely matched results when compared to the gold standard, liquid chromatography-tandem mass spectrometry (LC-MS/MS).
- Overall, the Cortisol II assay is deemed reliable for routine diagnostics, providing valuable reference ranges for healthy individuals.
Article Synopsis
- Liquid chromatography tandem mass spectrometry (LC-MS/MS) is enhancing steroid analysis through improved standardization, selectivity, and diversity, allowing for quicker diagnostics with high throughput.
- MS(3) technology increases specificity without extending analysis time, enabling the quantification of various steroids in complex samples like human plasma, urine, saliva, and hair.
- The method shows a high accuracy (89-107%) and a low imprecision (≤10%), though comparisons with traditional immunoassays indicate significant discrepancies in cortisol and aldosterone measurements; MS(3) is now recognized for its superior specificity and accuracy in these analyses.
Article Synopsis
- Salivary cortisol levels, important for assessing adrenal cortex function, were compared between immunoassay (IA) and liquid chromatography-tandem mass spectrometry (MS) methods in a study involving 169 children during stress tests.
- The results showed that while both methods yielded similar outcomes at different conditions, IA reported cortisol levels approximately 2.39 times higher than MS, primarily due to different standardization practices.
- The study concluded that although both methods are generally reliable for measuring cortisol dynamics, IA shows less accuracy when cortisol concentrations fall below 5 nmol/L.
Corticosteroid-binding globulin: modulating mechanisms of bioavailability of cortisol and its clinical implications.
Best Pract Res Clin Endocrinol Metab
October 2015
Article Synopsis
- - CBG (Corticosteroid-binding globulin) is the main protein that carries glucocorticoids in the bloodstream, binding 80-90% of serum cortisol, while only 5% remains unbound and active.
- - The review focuses on CBG's physical and chemical properties, its structure, and how it binds and releases cortisol, highlighting various factors like genetics and temperature that can impact CBG's function.
- - It also addresses the clinical significance of CBG abnormalities and how measuring CBG can help assess free cortisol levels in the body.
Article Synopsis
- Calcitonin (CTN) is a hormone produced by the thyroid's C-cells, and its levels in the blood can indicate C-cell activity, but various factors can lead to inconsistent assay results when diagnosing conditions like Medullary Thyroid Carcinoma (MTC) and C-cell hyperplasia (CCH).
- Elevated CTN levels (above 60-100 pg/mL) strongly suggest MTC, while values between 60 pg/mL and the cutoff require careful interpretation, as they could indicate either MTC or other conditions like C-cell hyperplasia.
- While enhanced diagnostic techniques involving pentagastrin or calcium-stimulated CTN measurements might provide better insights, the lack of accessibility and established cutoff
Article Synopsis
- The study investigates stress biomarkers in children, specifically how cortisol, cortisone, and alpha-amylase (AA) react to daily rhythms and the Trier Social Stress Test for Children (TSST-C).
- Analysis of saliva samples from children with internalizing disorders, externalizing disorders, and healthy controls found that while the circadian rhythm was consistent across groups, physiological responses to stress differed, particularly in cortisol and cortisone levels.
- The research concludes that altered stress responses can indicate underlying issues, with internalizing disorders showing a negative correlation between AA and cortisol, while externalizing disorders exhibited a positive correlation, suggesting different mechanisms of stress response across these conditions.