Induction of telomere shortening and cellular apoptosis by sodium meta-arsenite in human cancer cell lines.

The present study assessed the cytotoxicity of sodium meta-arsenite (SMA) on telomere shortening and cellular apoptosis in human A-549, MDA-MB-231 and U87-MG cancer cell lines. Following 2 weeks of 1 μM SMA treatment, population doubling time (PDT) was significantly ( < .05) increased by the inhibition of cell proliferation in all the cancer cell lines compared to that in untreated controls.

Differential gene expression profiles of radioresistant non-small-cell lung cancer cell lines established by fractionated irradiation: tumor protein p53-inducible protein 3 confers sensitivity to ionizing radiation.

Purpose: Despite the widespread use of radiotherapy as a local and regional modality for the treatment of cancer, some non-small-cell lung cancers commonly develop resistance to radiation. We thus sought to clarify the molecular mechanisms underlying resistance to radiation.

Methods And Materials: We established the radioresistant cell line H460R from radiosensitive parental H460 cells.