Publications by authors named "Yoon Young Seo"
Obesity requires treatment to mitigate the potential development of further metabolic disorders, including diabetes, hyperlipidemia, tumor growth, and non-alcoholic fatty liver disease. We investigated the anti-obesity effect of a 30% ethanol extract of (Kjellman) Setchell (EEB) on 3T3-L1 preadipocytes and high-fat diet (HFD)-induced obese C57BL/6 mice. Adipogenesis transcription factors including peroxisome proliferator-activated receptor (PPAR)γ, CCAAT/enhancer-binding protein-alpha (C/EBPα), and sterol regulatory element-binding protein-1 (SREBP-1) were ameliorated through the AMP-activated protein kinase (AMPK) pathway by EEB treatment in differentiated 3T3-L1 cells.
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- Many common pain management drugs, like acetaminophen and opioids, have side effects that can't be ignored, prompting researchers to explore new combinations for more effective treatments.
- The study focused on DW-1021, a combination of the NSAID pelubiprofen and the opioid tramadol, to see if it could provide better pain relief and anti-inflammatory effects compared to using either drug alone.
- Results showed that DW-1021 had strong pain-relieving effects and was particularly effective in reducing inflammation, suggesting it could be a promising new option for treating pain and inflammation.
Article Synopsis
- - Obesity is linked to serious health issues like type 2 diabetes and fatty liver disease, prompting research into solutions; this study examines the anti-obesity effects of a standardized extract from a plant variety called Makino (EECM).
- - Experiments showed that EECM reduced fat cell formation and fat storage by affecting specific proteins and enzymes involved in fat metabolism, while also inhibiting early stages of fat cell development in lab studies.
- - When tested on mice fed a high-fat diet, EECM not only decreased weight and fat accumulation but also improved hormone levels related to fat storage and balanced gut bacteria, suggesting it could be an effective treatment for obesity.
Repetitive exposure to ultraviolet B (UVB) is one of the main causes of skin photoaging. We previously reported that dieckol isolated from extract has potential anti-photoaging effects in UVB-irradiated Hs68 cells. Here, we aimed to evaluate the anti-photoaging activity of dieckol in a UVB-irradiated hairless mouse model.
View Article and Find Full Text PDFThe major contributor to skin aging is UV radiation, which activates pro-inflammatory cytokines including TNF-α. TNF-α is involved in the acceleration of skin aging via ROS generation and MMP-1 secretion. In our preliminary study, a 30% EtOH extract from the leaves of (LPCE) significantly inhibited TNF-α-induced ROS generation in human dermal fibroblasts (HDFs).
View Article and Find Full Text PDFIncreasing scientific evidence has demonstrated that the roots of Willd. have pharmacological effects related to anti-inflammation. Therefore, the aim of this study is to investigate the chemical constituents from .
View Article and Find Full Text PDFDA6034 promotes gastric epithelial cell migration and wound-healing through the mTOR pathway.
J Gastroenterol Hepatol
February 2012
Background And Aim: 7-Carboxymethyloxy-3',4',5-trimethoxy flavone (DA6034), a synthetic derivative of eupatilin, has a protective effect on gastric mucosa against various ulcerogens, and is currently in the phase III clinical trial in the treatment of peptic ulcer disease. Cell migration and/or growth plays a role in the repair process of gastric ulcer, so this study investigated the effect of DA6034 on the movement and proliferation of gastric epithelial cells and its associated signaling pathway.
Methods: The migration of AGS or SNU484 human gastric epithelial cells was shown by scratch-induced wound healing and transwell assays, and the proliferation of the cells was assessed by FACS and proliferation assays.