Antibacterial effect of electrospun polycaprolactone/polyethylene oxide/vancomycin nanofiber mat for prevention of periprosthetic infection and biofilm formation.

Objective: In this study, we developed a biocompatible and biodegradable vancomycin (VM)-eluting electrospun poly(ɛ-caprolactone) (PCL)/polyethylene oxide (PEO)/VM/PCL nanofiber mat. The purpose of this study was to evaluate the efficacy of this nanofiber mat for preventing methicillin-resistant Staphylococcus aureus (MRSA) biofilm on the ossicular prostheses and otitis media.

Materials And Methods: Fabrication of VM eluting nanofiber mat was carried out using PCL and PEO.

Tracheal regeneration using polycaprolactone/collagen-nanofiber coated with umbilical cord serum after partial resection.

Objectives: We developed a PCL/collagen nanofiber (PC-NF) scaffold/human umbilical cord serum (hUCS) to facilitate epithelial cell migration after implantation in order to promote regeneration of the tracheal epithelium without having a cell source.

Materials And Methods: The isolated chodrocytes from bovine auricle were used to evaluate the cellular activities cultured in the scaffolds with or without hUCS. A 4mm wide/8mm long, full thickness anterior defect was created in the tracheal rings of rats.

Recombinant human BMP-2 enhances osteogenesis of demineralized bone matrix in experimental mastoid obliteration.

Conclusions: From the results, recombinant human bone morphogenic protein 2 (rhBMP-2) activated demineralized bone matrix (DBM) for the enhancement of bone regeneration. These results might provide a basis for the clinical application of BMP-2 in mastoid obliteration.

Objective: The purpose of this study was to evaluate the enhanced osteogenesis of rhBMP-2-loaded DBM using a gelatin sponge in the mastoid obliteration model.

Effect of umbilical cord serum coated 3D PCL/alginate scaffold for mastoid obliteration.

Objective: Human umbilical cord serum (hUCS) has a lot of growth factors. To date, there are no reports on stimulating effect of hUCS in osteogenesis. The purpose of this study is to evaluate enhancing effect of hUCS in osteogenesis by mastoid obliteration combined with bony scaffold.

Effect of topical dexamethasone in reducing dysfunction after facial nerve crush injury in the rat.

Objective: To date, the effect of topical steroid after a crush injury to rat facial nerve has rarely been reported on. The aim of this study was to investigate the effects of topical dexamethasone on recovery after a crush injury to the rat facial nerve, by functional, electrophysiological, and morphological evaluation.

Materials And Methods: We investigated the effects of topical dexamethasone on recovery after a crush injury to rat facial nerve by functional, electrophysiological and morphological evaluation.

Comparision of osteoconductivity of biologic and artificial synthetic hydroxyapatite in experimental mastoid obliteration.

Conclusions: To our knowledge, this is the first in vivo study to address the comparison between biologic hydroxyapatite (BHA) and artificial HA (AHA) materials for mastoid obliteration. From our results, it is believed that BHA has better osteoconductivity than AHA.

Objective: The purpose of this study was to compare the osteoconductivity of AHA and BHA in a mastoid obliteration model in rats.

ALH-L1005 attenuates endotoxin induced inner ear damage.

Objective: To assess whether this compound (ALH-L1005) is conceivably an effective agent in protecting against cochlear damage induced by LPS.

Materials And Methods: Tube formation using human umbilical vein endothelial cell (HUVEC) and matrix metalloproteinase (MMP)-9 inhibition assay was performed. 24 guinea pigs were randomly divided into three groups.

Mastoid obliteration using 3D PCL scaffold in combination with alginate and rhBMP-2.

Various materials, both biological and alloplastic, have been used for mastoid obliteration after canal wall-down mastoidectomy in chronic otitis media. The purpose of this study is to investigate the osteoinductive potential of PCL scaffolds in mastoid obliteration, and to test that osteoinductivity can be enhanced by coating PCL with alginate and rhBMP-2. The in vitro biocompatibilities of the scaffolds were examined using osteoblast-like cells (MG63).

Bilateral cochlear implants in children.

The aim of this study was to investigate the impact of bilateral cochlear implants (CIs) use on speech perception in quiet and noise. The eleven children included in our study were prelingually deaf. With the two-stage technique, the two CIs were performed in all children.

Relationship between bone mineral density and clinical features in women with idiopathic benign paroxysmal positional vertigo.

Objective: To evaluate the relationship between bone mineral density (BMD) and clinical features in women with idiopathic benign paroxysmal positional vertigo (IBPPV).

Study Design: Prospective study.

Setting: Tertiary referral center.

Age-related changes on the morphology of the otoconia.

Objectives/hypothesis: Although there are numerous reports on otoconial morphology using field-emission scanning electron microscopy (FESEM), there are few reports regarding the changes of otoconial morphology with aging. The aim of the current study was to investigate changes in otoconial morphology in rats according to age, using FESEM.

Study Design: Laboratory study using experimental animals.