Publications by authors named "Yoon Seok Cha"
Article Synopsis
- KRAS mutations are significant for cancer treatment, affecting responses to therapies like EGFR inhibitors; testing for these mutations is crucial for personalized treatment.
- A new technique called restriction fragment mass polymorphism (RFMP) has been developed to effectively detect KRAS mutations in specific codons, showing higher sensitivity than traditional direct sequencing methods.
- The RFMP assay demonstrated reliable results in both lab cell lines and clinical lung cancer samples, indicating its potential use in clinical settings where tumor samples may include non-cancerous cells.
Short tandem repeat (STR) loci are routinely analyzed by capillary electrophoresis. However, this method has several disadvantages, including long operational time, low throughput, and inaccuracy. As a result of the introduction of matrix-associated laser desorption/ionization time-of-flight (MALDI-TOF) and electrospray ionization (ESI), mass spectrometry has become an alternative method for genotyping polymorphic STR loci.
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