Publications by authors named "Yoon Ha Park"
Background: Predose trough concentrations (C) of intravenous infliximab (IV-IFX) during maintenance therapy are associated with therapeutic outcomes in patients with Crohn's disease (CD). A subcutaneous formulation of infliximab (SC-IFX) has shown high C values due to its favourable pharmacokinetics.
Aims: To evaluate the association of C of SC-IFX with therapeutic outcomes and the threshold of SC-IFX C for achieving mucosal healing (MH) and transmural healing (TH) in patients with CD.
Article Synopsis
- - The study compared long-term outcomes between 61 IBD patients treated with subcutaneous (SC) infliximab and 23 patients continuing with intravenous (IV) infliximab during maintenance therapy, with a focus on remission rates and safety over one year.
- - Results showed that while clinical and biochemical remission rates were similar for both groups, the SC group had a significantly higher durable remission rate (82% vs. 48%) and lower instances of low infliximab levels.
- - Both treatment methods had comparable safety profiles, suggesting SC infliximab may be a more effective option for maintaining remission in IBD patients.
While many deep-learning-based computer-aided detection systems (CAD) have been developed and commercialized for abnormality detection in chest radiographs (CXR), their ability to localize a target abnormality is rarely reported. Localization accuracy is important in terms of model interpretability, which is crucial in clinical settings. Moreover, diagnostic performances are likely to vary depending on thresholds which define an accurate localization.
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