IL-13 and STAT6 signaling involve in low dose lipopolysaccharide induced murine model of asthma.

Background: We reported that level of lipopolysaccharide (LPS) exposure determined the type of airway inflammation in a murine model of asthma.

Objective: The purpose of this study is to evaluated the role of IL-13 in low dose LPS induced murine model of asthma using IL-13 and signal transducer and activator of transcription 6 (STAT6) deficient mice.

Methods: Mice were sensitized with an intranasal application of LPS-depleted ovalbumin (OA) and different doses of LPS (0.