Publications by authors named "Yoo-Jin Jang"
Escitalopram is commonly prescribed for depressive and anxiety disorders in elderly patients, who often show variable drug responses and face higher risks of side effects due to age-related changes in organ function. The CYP2C19 polymorphism may further affect escitalopram pharmacokinetics in elderly patients, complicating dose optimization for this group. Previous pharmacogenetic studies examining the impact of CYP2C19 phenotype on escitalopram treatment outcomes have primarily focused on younger adults, leaving a gap in understanding its effects on the elderly.
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- - This study investigated the link between late-onset depression (LOD) and amyloid deposition in the brain, comparing 40 LOD patients (diagnosed after age 60) with 21 healthy controls (HC) using PET imaging and neuropsychological tests.
- - Results showed no significant differences in amyloid-beta (Aβ) levels between LOD patients and HC, and Aβ levels did not correlate with the severity of depressive symptoms; however, higher somatic anxiety was linked to lower Aβ levels in certain brain areas.
- - While cognitive improvements were observed in LOD patients after three months of antidepressant treatment, these improvements did not correlate with changes in amyloid deposition, suggesting different underlying mechanisms for cognitive recovery and amy
Introduction: Despite the ethnic differences in ( allele relates to better antidepressant response in Korean and Japanese people, while allele with better response in Caucasians), it is unclear whether and its high expression locus are interactively associated with antidepressant treatment outcome. We investigated the individual and interaction effects of these polymorphisms on antidepressant treatment outcomes in the Korean population.
Methods: A total of 464 Korean subjects with major depressive disorder completed 6 weeks of antidepressant monotherapy.
Background: Dementia is a progressive neurocognitive disease with a substantial social burden. No apparent breakthroughs in treatment options have emerged so far; thus, disease prevention is essential for at-risk populations. Depression and cerebrovascular disease (CVD) are independent risk factors for dementia, but no studies have examined their interaction effect on dementia risk.
View Article and Find Full Text PDFEfficient and specific generation of knockout mice using CRISPR/Cas9 system.
Biochem Biophys Rep
July 2020
The CRISPR/Cas9 (SpCas9) system is now widely utilized to generate genome engineered mice; however, some studies raised issues related to off-target mutations with this system. Herein, we utilized the Cas9 (CjCas9) system to generate knockout mice. We designed sgRNAs targeting mouse or and microinjected into zygotes along with CjCas9 mRNA.
View Article and Find Full Text PDFAlopecia areata (AA) is an autoimmune disease that results in spot baldness in humans. Adequate animal models for AA are currently lacking. The objective of this study was to elucidate the mechanism of autoimmune-like alopecia (ALA) in C57BL/6.
View Article and Find Full Text PDFObjectives: This report describes the development process of a drug dosing database for ethical drugs approved by the Korea Food & Drug Administration (KFDA). The goal of this study was to develop a computerized system that supports physicians' prescribing decisions, particularly in regards to medication dosing.
Methods: The advisory committee, comprised of doctors, pharmacists, and nurses from the Seoul National University Bundang Hospital, pharmacists familiar with drug databases, KFDA officials, and software developers from the BIT Computer Co.