Publications by authors named "Yonsheng Guan"
To produce seeds, flowering plants need to specify somatic cells to undergo meiosis. Here, we reveal a regulatory cascade that controls the entry into meiosis starting with a group of redundantly acting cyclin-dependent kinase (CDK) inhibitors of the KIP-RELATED PROTEIN (KRP) class. KRPs function by restricting CDKA;1-dependent inactivation of the Retinoblastoma homolog RBR1.
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- CDKs are usually inhibited during DNA damage to stop cell division, but they are necessary for DNA repair, particularly homology-dependent repair (HR).
- Researchers discovered that Arabidopsis thaliana uses a "division of labor" approach, where B1-type CDKs and cyclins are key players in HR.
- Specifically, CDKB1-CYCB1 complexes activate RAD51, a crucial protein for DNA repair, after DNA damage, while mitotic cell-cycle activity is still blocked.