Publications by authors named "Yonit Maroudas-Sacks"
One of the major events in animal morphogenesis is the emergence of a polar body axis. Here, we combine classic grafting techniques with live imaging to explore the plasticity of polarity determination during whole body regeneration in Hydra. Composite tissues are made by fusing two rings, excised from separate animals, in different configurations that vary in the polarity and original positions of the rings along the body axes of the parent animals.
View Article and Find Full Text PDFThe emergence and stabilization of a body axis is a major step in animal morphogenesis, determining the symmetry of the body plan as well as its polarity. To advance our understanding of the emergence of body axis polarity, we study regenerating . Axis polarity is strongly memorized in regeneration even in small tissue segments.
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- - Morphogenesis is a key biological process that forms complex patterns in organisms, but we still don't fully grasp how it consistently works across different conditions and scales.
- - The review emphasizes the importance of mechanical processes in shaping developmental patterns, which actively engage with biochemical signals instead of just following them.
- - A holistic "coarse-grained" approach is proposed to better understand large-scale dynamics and feedback in morphogenesis, highlighting the need to identify crucial variables and develop effective theories for a comprehensive understanding.
Article Synopsis
- Recent advancements in various scientific fields have reignited interest in how mechanical and biochemical interactions contribute to the organization of cells and tissues.
- New technologies in microscopy and computational analysis allow for better observation and understanding of patterns related to signaling and force generation in living systems.
- This roadmap presents diverse case studies exploring the dynamic relationship between mechanics and biochemistry, emphasizing its role in shaping organismal development through various processes across different scales and organisms.
A growing amount of experimental evidence shows that the local elastic field acting on cells governs their spatial organization and polarity in a tissue. Interestingly, experiments on wound healing reveal a universal formation of thick actomyosin bundles around the margins of epithelial gaps. Although the forces involved in this process have been measured, the mechanisms governing cellular alignment and contractile ring formation are still not fully understood.
View Article and Find Full Text PDFUnderstanding how mechanics complement bio-signaling in defining patterns during morphogenesis is an outstanding challenge. Here, we utilize the multicellular polyp Hydra to investigate the role of the actomyosin cytoskeleton in morphogenesis. We find that the supra-cellular actin fiber organization is inherited from the parent Hydra and determines the body axis in regenerating tissue segments.
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