Synthesis and antibacterial activities of novel pleuromutilin derivatives.

Pleuromutilin derivatives 4a-h, 5a-g, and 6a-d were synthesized and characterized by IR, H NMR, and C NMR. All synthetic compounds were screened for their in vitro antibacterial activity against Staphylococcus aureus (ATCC 25923), methicillin-resistant S. aureus (MRSA, ATCC 43300), Pasteurella multocida (CVCC 408), Escherichia coli (ATCC 25922), and Salmonella typhimurium (ATCC 14028).