Publications by authors named "Yongzhen Fang"
The inconsistency between mismatch repair (MMR) protein immunohistochemistry (IHC) and microsatellite instability PCR (MSI-PCR) methods has been widely reported. We aim to investigate the prognosis and the effect of immunotherapy in dMMR by IHC but MSS by MSI-PCR (dMMR&MSS) colorectal cancer (CRC) patients. A microsatellite instability (MSI) predicting model was established to help find dMMR&MSS patients.
View Article and Find Full Text PDFBackground: promoter methylation analysis is recommended in screening for Lynch syndrome (LS) in patients with MLH1-deficient colorectal cancer (CRC). The study aims to identify specific methylation regions in the promoter and to evaluate the clinicopathologic characteristics of and prognosis for patients with methylation.
Methods: A total of 580 CRC cases were included.
Article Synopsis
- * Researchers tested MSI status in 2572 patients using the National Cancer Institute (NCI) panel and two mononucleotide panels, and conducted mismatch repair protein testing through immunohistochemistry (IHC) on 1976 samples.
- * Results showed that the two mononucleotide panels had significantly lower misdiagnosis rates compared to the NCI panel in detecting MSI, suggesting that these panels are more effective for identifying MSI in CRC and GC patients.
Objective: To study the cardiovascular risk factors and clinical medications in patients with cardiovascular disease in Guangzhou hospitals.
Methods: Cluster sampling and non-random sampling methods were used to analyze the cardiovascular risk factors and clinical medications among the 6691 inpatients with cardiovascular diseases in the department of cardiology of 9 large general hospitals in Guangzhou during 1995-2005.
Results: Compared with the data in 1995, the incidences of hypertension, type 2 diabetes, and hypertriglyceridemia increased while hypercholesteremia, elevated low-density lipoprotein, and low high-density lipoprotein levels decreased in 2005.