Antitumor activity of polysaccharides with different molecular weights: an and study.

The antitumor activity of polysaccharide (LBP) has been reported, but the structure-bioactivity relationship has still not been fully elucidated. In this study, four water-soluble LBP fractions with serial different molecular weights (MWs) were separated from LBP, designated LBP-2, LBP-3, LBP-4, and LBP-5. After a characteristic analysis, the relationship between MW and antitumor activity of LBP was investigated both using murine hepatoma H22 cells and using H22 tumor-bearing mice.