Publications by authors named "Yongyan An"
Lipin1 depletion coordinates neuronal signaling pathways to promote motor and sensory axon regeneration after spinal cord injury.
Proc Natl Acad Sci U S A
September 2024
Article Synopsis
- Adult CNS neurons stop growth after injury, causing ongoing issues with regeneration due to disrupted lipid metabolism.
- The study discovers that lipin1 plays a key role in regulating mTOR and STAT3 signaling pathways, which impacts axon regeneration.
- Knocking down lipin1 boosts axon growth in specific spinal cord pathways, suggesting it could be a valuable target for therapies aimed at enhancing recovery after spinal cord injuries.
Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis.
Neuron
January 2023
The coordination mechanism of neural innate immune responses for axon regeneration is not well understood. Here, we showed that neuronal deletion of protein tyrosine phosphatase non-receptor type 2 sustains the IFNγ-STAT1 activity in retinal ganglion cells (RGCs) to promote axon regeneration after injury, independent of mTOR or STAT3. DNA-damage-induced cGAMP synthase (cGAS)-stimulator of interferon genes (STINGs) activation is the functional downstream signaling.
View Article and Find Full Text PDFCECR2 drives breast cancer metastasis by promoting NF-κB signaling and macrophage-mediated immune suppression.
Sci Transl Med
February 2022
Metastasis is the major cause of cancer-related deaths due to the lack of effective therapies. Emerging evidence suggests that certain epigenetic and transcriptional regulators drive cancer metastasis and could be targeted for metastasis treatment. To identify epigenetic regulators of breast cancer metastasis, we profiled the transcriptomes of matched pairs of primary breast tumors and metastases from human patients.
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