Publications by authors named "Yongxue Zhu"
New advances in the therapeutic strategy of head and neck squamous cell carcinoma: A review of latest therapies and cutting-edge research.
Biochim Biophys Acta Rev Cancer
February 2025
Article Synopsis
- Head and neck squamous cell carcinoma (HNSCC) is a challenging and aggressive cancer with a low five-year survival rate, especially at advanced stages, due to high recurrence and resistance to current treatments.
- Recent advancements in therapy for HNSCC include targeted therapies like EGFR inhibitors, immunotherapy with PD-1/PD-L1 blockade, and innovative drug delivery methods such as nanotechnology, aimed at enhancing treatment effectiveness.
- Ongoing research focuses on the tumor microenvironment and the epithelial-mesenchymal transition (EMT) to inform personalized treatment strategies and improve patient outcomes in HNSCC.
Article Synopsis
- This study evaluated the effectiveness and safety of combining induction chemotherapy with a PD-1 inhibitor (toripalimab) for preserving the larynx in patients with advanced laryngeal and hypopharyngeal cancer.
- A total of 27 patients were treated, showing a high overall response rate of 85.2% and a larynx preservation rate of 88.9% three months after radiation therapy.
- Findings suggest that this treatment approach can offer significant larynx preservation, especially in patients not requiring a tracheostomy prior to treatment, and indicates potential associations between tumor relapse and certain genetic markers.
Selective Treatment Deintensification by Reducing Radiation Dose and Omitting Concurrent Chemotherapy Based on Response to Induction Chemotherapy in Human Papillomavirus-Associated Oropharyngeal Squamous Cell Carcinoma: A Single-Arm, Phase 2 Trial (IChoice-01).
Int J Radiat Oncol Biol Phys
January 2024
Purpose: To demonstrate the feasibility of deintensification regimen in the light of the response to induction chemotherapy (IC) in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC).
Methods And Materials: Patients with p16+ OPSCC, T1-2/N1-3M0 (excluding T1N1M0 with single and ≤3 cm lymph node) or T3-4N0-3M0 were enrolled between January 2019 and July 2021. All patients received 2 cycles of IC with docetaxel 75 mg/m dL and cisplatin 75 mg/m dL every 3 weeks.
Prognostic and clinical significance of HOXC9 and HOXD10 in papillary thyroid cancer.
Transl Cancer Res
July 2021
Background: The homebox superfamily play an important role in tumorigenesis. HOXC9 and HOXD10 were reported playing critical roles in tumor progression in many malignant tumors. This study aimed to research the expression of HOXC9 and HOXD10 in papillary thyroid cancer, and to verify the prognostic and clinical significance of HOXC9 and HOXD10.
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- Neuregulin 1 (NRG1) is a key protein involved in cell signaling and organ development, and this study investigates its potential as a diagnostic tool for identifying BRAF V600E mutations in papillary thyroid cancer (PTC) patients by analyzing changes in its sugar (glycan) patterns.
- Serum samples from PTC patients were examined using techniques like immunohistochemical staining and lectin assays to determine glycan alterations in NRG1, revealing specific lectins that showed stronger binding in patients with the mutant BRAF gene.
- The findings suggest that NRG1 glycosylation can help differentiate PTC patients with BRAF mutations from those without, potentially serving as a supplementary biomarker in clinical diagnostics
Background: Prognostic evaluation model for papillary thyroid cancer is very important for guiding the personalized treatment and follow-up strategy. There are imperfections in the system existed, and there is no suitable prognostic model for Chinese population.
Methods: This study was based on the clinic and follow-up data of 660 patients received surgical treatments in the Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center from 2000 to 2005.
Corrigendum to: Gene expression profiling of cells of origin of squamous cell carcinomas in head-and-neck, esophagus, and lung.
Acta Biochim Biophys Sin (Shanghai)
September 2020
Article Synopsis
- Bone brown tumors linked to primary hyperparathyroidism (PHPT) are rare, affecting only 2-5% of patients.
- A female patient was initially misdiagnosed with multiple malignant bone tumors but was later correctly identified as having a brown tumor due to hyperparathyroidism.
- The article details her diagnosis and treatment journey, while also reviewing similar cases from the past decade to enhance future diagnostic and treatment strategies.
Gene expression profiling of cells of origin of squamous cell carcinomas in head-and-neck, esophagus, and lung.
Acta Biochim Biophys Sin (Shanghai)
February 2020
Background: The purpose was to investigate the prognosis of patients with synchronous and metachronous squamous cell carcinoma of head and neck (HNSCC) and esophagus (ESCC), and to evaluate the prognostic factors of these patients.
Methods: A retrospective review was performed on 70 patients with synchronous and metachronous HNSCC and ESCC treated in our institution from January 2005 to December 2016. Kaplan-Meier method and Cox proportional hazard model were used to evaluate overall survival (OS) and determine the prognostic factors associated with survival outcomes.
Background: Lymph node yield (LNY) was implemented in the stratification of papillary thyroid cancer (PTC) patients. The effect of LNY may be related to the extent of surgery. This study aims to identify influencing factors for LNY in central compartment neck dissection (CND).
View Article and Find Full Text PDFBackground: Papillary thyroid cancer (PTC) has a strong propensity to metastasize to the cervical lymph nodes. Little was known currently about whether tumor's location would influence the risk of lymph node metastasis in PTC.
Methods: The study enrolled PTC patients who underwent primary surgical therapy in our center for small unifocal tumor.
Background: Thyroid cancer is the most common endocrine malignant disease in children and adolescents. There is a trend of more conservative strategies including lobectomy and less radioactive iodine therapy (RAI) in multifocal papillary thyroid cancer (PTC) for its good survival outcome. The aim of our study was to define long-time outcome of a large cohort of multifocal PTC patients less than 20 years old treated at our institution.
View Article and Find Full Text PDFBackground: To explore whether deep convolutional neural networks (DCNNs) have the potential to improve diagnostic efficiency and increase the level of interobserver agreement in the classification of thyroid nodules in histopathological slides.
Methods: A total of 11,715 fragmented images from 806 patients' original histological images were divided into a training dataset and a test dataset. Inception-ResNet-v2 and VGG-19 were trained using the training dataset and tested using the test dataset to determine the diagnostic efficiencies of different histologic types of thyroid nodules, including normal tissue, adenoma, nodular goiter, papillary thyroid carcinoma (PTC), follicular thyroid carcinoma (FTC), medullary thyroid carcinoma (MTC) and anaplastic thyroid carcinoma (ATC).
Background: In this study, we exploited the Inception-v3 deep convolutional neural network (DCNN) model to differentiate cervical lymphadenopathy using cytological images.
Methods: A dataset of 80 cases was collected through the fine-needle aspiration (FNA) of enlarged cervical lymph nodes, which consisted of 20 cases of reactive lymphoid hyperplasia, 24 cases of non-Hodgkin's lymphoma (NHL), 16 cases of squamous cell carcinoma (SCC), and 20 cases of adenocarcinoma. The images were cropped into fragmented images and divided into a training dataset and a test dataset.
Article Synopsis
- - Warburg discovered that tumor cells rely heavily on glycolysis for energy, even when oxygen is available, a phenomenon called the 'Warburg effect', but recent findings suggest that metabolic changes in cancer cells are more complex than he initially thought.
- - Thyroid cancer, a common type of endocrine tumor, has shown notable metabolic changes in recent research, leading to ongoing clinical trials for drugs that target these metabolic pathways.
- - The article aims to explore the metabolic alterations in thyroid cancer to identify potential biomarkers for prognosis and therapeutic targets, emphasizing the importance of further studies to validate these findings.
Benefits of subdividing small-differentiated thyroid carcinoma (sDTC) by tumor size are controversial. We conducted a meta-analysis to investigate whether tumor size is associated with prognosis of sDTC. PubMed and Web of Science databases were searched from their inception to September 2018.
View Article and Find Full Text PDFThyroid cancer is a common endocrine cancer, of which papillary thyroid cancer (PTC) is the most common type. Neuregulin 1 (NRG1), a glycoprotein mediating cell‑cell signaling, plays vital roles in cellular activities; however, its role in PTC progression remains poorly understood. In this study, we performed immunohistochemistry in 196 samples from patients and found that NRG1, a potential prognostic marker is highly expressed in PTC compared with adjacent normal tissues.
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- Verteporfin, a second-generation photosensitizer, is FDA-approved and has shown anticancer properties, but has not been previously studied in papillary thyroid cancer (PTC).
- This pre-clinical pilot study reveals that verteporfin decreases cell proliferation, causes apoptosis, and stops the cell cycle in the G2/S phase in PTC cells while significantly inhibiting tumor growth in mouse models.
- The research also indicates that combining verteporfin with the MEK inhibitor U0126 affects ERK1/2 signaling, suggesting that verteporfin could be a promising treatment option for PTC.
Background: Lymph node metastasis is important when evaluating the prognosis of patients with differentiated thyroid cancer (DTC). However, the current N-staging system cannot fully reflect the clinical significance of cervical lymph node metastasis in DTC. In this study, we employed Surveillance, Epidemiology, and End Results (SEER)-registered DTC cases with lymph node metastasis to determine whether the positive lymph node number (PLNN) could be used to improve stratification of patients in terms of survival.
View Article and Find Full Text PDFEpigenetic abnormalities as well as genetic abnormalities may play a vital role in the tumorigenesis of papillary thyroid cancer (PTC). The present study aimed to analyze the function and methylation status of the HOXD10 gene in PTC and aimed to identify relationships between HOXD10 methylation, HOXD10 expression, BRAF mutation and clinicopathological characteristics of PTC. A total of 152 PTC patients were enrolled in the present study.
View Article and Find Full Text PDFThe mammalian peptide hormone stanniocalcin 2 (STC2) plays an oncogenic role in many human cancers. However, the exact function of STC2 in human head and neck squamous cell carcinoma (HNSCC) is unclear. We aimed to examine the function and clinical significance of STC2 in HNSCC.
View Article and Find Full Text PDFLong non-coding RNAs (lncRNAs) participate in cancer cell tumorigenesis, cell cycle control, migration, proliferation, apoptosis, metastasis and drug resistance. The BRAF-activated non-coding RNA (BANCR) functions as both an oncogene and a tumor suppressor. Here, we investigated BANCR's role in papillary thyroid carcinoma (PTC) by assessing BANCR levels in PTC and matched normal thyroid epithelial tissues from 92 patients using qRT-PCR.
View Article and Find Full Text PDFPapillary thyroid cancer (PTC) often presents as multifocal tumor;, however, whether multifocality is associated with poor prognosis remains controversial. The aims of this retrospective study were to identify the characteristics of PTC with multifocal tumors and evaluate the association between the location and prognosis. We reviewed the medical records of 496 patients who underwent total thyroidectomy for PTC.
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- * Of the patients, 364 had coexistent HT, which was characterized by a higher percentage of females, elevated thyroid-stimulating hormone (TSH) levels, and a lower rate of extrathyroidal extension compared to patients without HT.
- * Despite these differences, the incidence of LNM and cancer recurrence were similar in both groups, indicating that HT had no significant protective impact on prognosis, contrary to previous research, and suggesting a