A New Screening Strategy for Flavonoid Components to Obtain a Satisfactory Co-Amorphous System with Piperine.

Flavonoids are a large class of compounds with a variety of biological activities. Nevertheless, their therapeutic application remains limited due to the generally low water solubility. In the present study, an integrated approach was provided to guide the design of flavonoid co-amorphous systems co-formed with piperine (PIP).

Pongamol Alleviates Neuroinflammation and Promotes Autophagy in Alzheimer's Disease by Regulating the Akt/mTOR Signaling Pathway.

Alzheimer's disease (AD), one of the neurodegenerative disorders, is highly correlated with the abnormal hyperphosphorylation of Tau and aggregation of β-amyloid (Aβ). Oxidative stress, neuroinflammation, and abnormal autophagy are key drivers of AD and how they contribute to neuropathology remains largely unknown. The flavonoid compound pongamol is reported to possess a variety of pharmacological activities, such as antioxidant, antibacterial, and anti-inflammatory.