H1N1 swine influenza viruses upregulate NEU1 expression through histone H3 acetylation regulated by HDAC2.

Mammalian membrane sialic acid is the key receptor for influenza virus. Sialidases, the main type of enzyme that can hydrolyze membrane sialic acids in mammalian cells, have the potential to affect the invasion process of influenza viruses, including H1N1. For the first time, this study focused on the regulation mechanism of sialidase NEU1 expression, and revealed that swine-origin influenza (H1N1) virus infection can promote NEU1 expression through histone H3 acetylation, which is regulated by HDAC2 in host cells.

Alisol A Exerts Neuroprotective Effects Against HFD-Induced Pathological Brain Aging via the SIRT3-NF-κB/MAPK Pathway.

Chronic consumption of a high-fat diet (HFD) has profound effects on brain aging, which is mainly characterized by cognitive decline, inflammatory responses, and neurovascular damage. Alisol A (AA) is a triterpenoid with therapeutic potential for metabolic diseases, but whether it has a neuroprotective effect against brain aging caused by a HFD has not been investigated. Six-month-old male C57BL6/J mice were exposed to a HFD with or without AA treatment for 12 weeks.

Diet Control and Swimming Exercise Ameliorate HFD-Induced Cognitive Impairment Related to the SIRT1-NF-B/PGC-1 Pathways in ApoE-/- Mice.

High-fat diet- (HFD-) induced neuroinflammation may ultimately lead to an increased risk of cognitive impairment. Here, we evaluate the effects of diet control and swimming or both on the prevention of cognitive impairment by enhancing SIRT1 activity. Twenty-week-old ApoE-/- mice were fed a HFD for 8 weeks and then were treated with diet control and/or swimming for 8 weeks.

Swimming Training Mitigates Neurological Impairment of Intracerebral Haemorrhage in Mice via the Serine-Threonine Kinase/Glycogen Synthase Kinase 3β Signalling Pathway.

Swimming training (ST) can mitigate functional disorders in neurological diseases, but the effect and mechanism of ST in improving the neurological function of intracerebral haemorrhage (ICH) have not been reported. Our study aimed to explore the protective effect of early ST on ICH mice and its relationship with the serine-threonine kinase (Akt)/glycogen synthase kinase 3β (GSK3β) pathway. Our findings showed that the ICH model mice had poor behavioural manifestations in the Y maze test and open field test compared to the ST group and sham group.

TRAF4 Maintains Deubiquitination of Caveolin-1 to Drive Glioblastoma Stemness and Temozolomide Resistance.

Unlabelled: Glioblastoma (GBM) is the most common type of primary adult brain tumor. Glioma stem cell (GSC) residence and temozolomide (TMZ) resistance in GBM both contribute to poor patient outcome. TRAF4 is a scaffold protein with E3 ubiquitin ligase activity that has recently been discovered to promote invasion and metastasis in several malignancies, but the effects and functions of TRAF4 in GBM remain to be determined.

Comprehensive utilization of palm kernel cake for producing mannose and manno-oligosaccharide mixture and yeast culture.

Palm kernel cake (PKC) is an agricultural waste derived from palm kernel oil manufacturing, and its production is increasing year by year. It is very urgent to process this agricultural waste in an environmentally friendly way. Here, PKC was used to produce mannose and manno-oligosaccharides mixture (MMOM) and yeast culture (YC) through enzymolysis and solid-state fermentation (SSF).

A novel kinase inhibitor, LZT-106, downregulates Mcl-1 and sensitizes colorectal cancer cells to BH3 mimetic ABT-199 by targeting CDK9 and GSK-3β signaling.

Colorectal cancer (CRC) is one of the most common malignancies worldwide and is associated with poor prognosis and high mortality. Despite advances in treatment with chemotherapy, CRC remains a major cause of drug resistance-related cancer deaths. One of the main reasons for such resistance is dysregulation of Mcl-1 expression.

CRMP2 is a therapeutic target that suppresses the aggressiveness of breast cancer cells by stabilizing RECK.

Metastatic breast cancer is characterized by high mortality and limited therapeutic target. During tumor metastasis, cytoskeletal reorganization is one of the key steps in the migration and invasion of breast cancer cells. Collapsin response mediator protein 2 (CRMP2) is a cytosolic phosphoprotein that plays an important role in regulating cytoskeletal dynamics.

Full-Waveform LiDAR Point Clouds Classification Based on Wavelet Support Vector Machine and Ensemble Learning.

Light Detection and Ranging (LiDAR) produces 3D point clouds that describe ground objects, and has been used to make object interpretation in many cases. However, traditional LiDAR only records discrete echo signals and provides limited feature parameters of point clouds, while full-waveform LiDAR (FWL) records the backscattered echo in the form of a waveform, which provides more echo information. With the development of machine learning, support vector machine (SVM) is one of the commonly used classifiers to deal with high dimensional data via small amount of samples.

Channel capacity of orbital-angular-momentum-based wireless communication systems with partially coherent elegant Laguerre-Gaussian beams in oceanic turbulence.

For practical wireless communication links, one of the critical challenges is the random fluctuation of turbulence that will impair link performance. Here a transmission model of partially coherent elegant Laguerre-Gaussian (ELG) beams in oceanic turbulence is established. An analytical formula for channel capacity of a partially coherent ELG beam propagating through a turbulent ocean is derived.

Propagation and dynamical characteristics of a Bessel-Gaussian beam in a chiral medium.

Based on the ABCD transfer matrix and Collins formula, the analytical expressions of the complex amplitude of the Bessel-Gaussian beam in a chiral medium are derived. By introducing vector potential in the Lorentz gauge, the electromagnetic field components of the Bessel-Gaussian beam are determined under the paraxial approximation. Through numerical calculations, the propagation of the Bessel-Gaussian beam in a chiral medium is examined.