ERBB2 promoter demethylation and immune cell infiltration promote a poor prognosis for cancer patients.

Background: Receptor tyrosine-protein kinase erbB-2 (ERBB2) expression is a critical factor for the prognosis of various cancers. ERBB2 enrichment indicates a poor prognosis in some cancer types but could be a favorable prognostic factor in others.

Methods: We analyzed DNA methylation, mRNA, protein, immune cell infiltration, and related signaling pathways using TIMER2.