Publications by authors named "Yongxin Yu"

In our previous study, a strain of Pseudomonas composti ODT-54 was isolated from the oyster digestive tissues. This strain is capable of producing Psl exopolysaccharides (EPS), which are directly involved in the specific binding to norovirus GII.6 P proteins.

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Background: As a globally farmed oyster species, Magallana gigas has garnered significant attention due to the contaminated RNA viruses that have caused illness in humans. However, limited knowledge is available on the bioaccumulation status and overall diversity of RNA virome in the M. gigas digestive tissues (DTs).

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Melanoma is a highly malignant skin tumor characterized by high metastasis and poor prognosis. Recent studies have highlighted the pivotal role of melanoma stem cells (MSCs)-a subpopulation of cancer stem cells (CSCs)-in driving tumor growth, metastasis, therapeutic resistance, and recurrence. Similar to CSCs in other cancers, MSCs possess unique characteristics, including specific surface markers, dysregulated signaling pathways, and the ability to thrive within complex tumor microenvironment (TME).

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Archaea play a significant role in natural ecosystems and the human body. Archaeal viruses exert a considerable influence on the structure and composition of archaeal communities and their associated ecological environments. The present study revealed the complete genomes of 38 archaeal head-tailed proviruses through comprehensive data mining.

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Article Synopsis
  • Ferroptosis, a form of cell death driven by iron and lipid peroxides, plays a crucial role in treating liver cancer (hepatocellular carcinoma) and curcumin has strong anti-tumor properties.
  • The study aimed to assess curcumin's effectiveness in inhibiting liver cancer cells both in laboratory settings and in live models, using specific cancer cell lines and tumor xenografts.
  • Results showed that curcumin reduced liver cancer cell growth and induced ferroptosis by altering levels of certain biomarkers, indicating that ACSL4 could be a target for enhancing the effects of curcumin in liver cancer treatment.
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The intricate physiological and pathological diversity of the Renin-Angiotensin-Aldosterone System (RAAS) underpins its role in maintaining bodily equilibrium. This paper delves into the classical axis (Renin-ACE-Ang II-AT1R axis), the protective arm (ACE2-Ang (1-7)-MasR axis), the prorenin-PRR-MAP kinases ERK1/2 axis, and the Ang IV-AT4R-IRAP cascade of RAAS, examining their functions in both physiological and pathological states. The dysregulation or hyperactivation of RAAS is intricately linked to numerous diseases, including cardiovascular disease (CVD), renal damage, metabolic disease, eye disease, Gastrointestinal disease, nervous system and reproductive system diseases.

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  • AHPND is a severe shrimp disease caused by a specific strain of Vibrio that contains the virulence plasmid pAHPND with key genes (pirAB) responsible for its lethality.
  • Researchers identified a genetic element related to another bacterium and discovered two related plasmids (pAHPND-r1 and pAHPND-r2) that might have contributed to the creation of pAHPND.
  • The study suggests that the emergence of pAHPND involved genetic recombination processes, leading to the effective horizontal transfer of this plasmid, which is crucial for understanding how the disease spreads among shrimp populations.
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  • Hepatocellular carcinoma (HCC) is a highly fatal cancer, and this study explores the potential of ginsenoside RK1 as a treatment by inducing ferroptosis, a type of programmed cell death.
  • Researchers tested ginsenoside RK1 on HepG2 HCC cells using various concentrations, assessing its effects on cell viability, cytotoxicity, and the expression of ferroptosis-related genes.
  • The findings indicate that ginsenoside RK1 significantly reduces HCC cell viability and colony formation, promotes ferroptosis by altering key intracellular substances, and its effectiveness is influenced by the expression of specific ferroptosis-related proteins.
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The metabolic reconfiguration of tumor cells constitutes a pivotal aspect of tumor proliferation and advancement. This study delves into two primary facets of tumor metabolism: the Warburg effect and mitochondrial metabolism, elucidating their contributions to tumor dominance. The Warburg effect facilitates efficient energy acquisition by tumor cells through aerobic glycolysis and lactic acid fermentation, offering metabolic advantages conducive to growth and proliferation.

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Article Synopsis
  • - Lung cancer, particularly the non-small cell variant (NSCLC) with lung adenocarcinoma (LUAD) as the main subtype, is a major cause of cancer deaths globally, and current early diagnostic methods are not effective enough.
  • - Researchers used bioinformatics to find 10 key genes linked to survival in early-stage LUAD patients, using data from platforms like GEO and TCGA.
  • - They discovered Aminopurvalanol A as a potential treatment connected to these genes, validating its effectiveness and safety through further experiments, which may enhance clinical management for early LUAD detection and treatment.
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Ferroptosis is an iron ion-dependent, regulatory cell death modality driven by intracellular lipid peroxidation that plays a key role in the development of HCC. Studies have shown that various clinical agents (e.g.

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Mycophenolate mofetil (MMF) is a viable therapeutic option against various immune disorders as a chemotherapeutic agent. Nevertheless, its application has been undermined by the gastrotoxic metabolites (mycophenolic acid glucuronide, MPAG) produced by microbiome-associated β-glucuronidase (βGUS). Therefore, controlling microbiota-produced βGUS underlines the potential strategy to improve MMF efficacy by overcoming the dosage limitation.

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  • The study explores the electronic and transport properties of molecular junctions created with self-assembled monolayers (SAMs) of alkyl chains and acetylene groups on various metal electrodes.
  • Results indicate that the current-voltage characteristics can be accurately modeled using a single-level model and reveal that conductance follows the metal work function order; however, transport is predominantly influenced by the HOMO-1 level rather than the HOMO.
  • The research highlights significant differences between the behavior of junctions with acetylene groups and those with thiol groups, particularly in how the AFM tip affects energy level alignment and the unique electronic properties of the alkyne functional group.
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Gene knockout is a widely used technique for engineering bacterial genomes, investigating the roles of genes in metabolism, and conferring biological characteristics. Herein, we developed a rapid, efficient, and simple method for the knockout of long gene cassettes in Pseudomonas spp., based on a traditional allelic exchange strategy.

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  • Researchers identified and sequenced the whole genomes of seven uncultured dsDNA bacteriophages in Dishui Lake, the largest artificial lake in Shanghai.
  • The genomic analysis revealed viral auxiliary metabolic genes linked to protein synthesis and host metabolism, indicating a complex interaction with their bacterial hosts.
  • The study advances our understanding of bacteriophage diversity and composition in freshwater ecosystems, suggesting these phages share more genetic similarities with uncultivated environmental viruses than with established reference viruses.
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RNA viruses in marine environments have long been recognized as major players in the virosphere. In this study, the complete genome sequence of an RNA virus from Yangshan Harbor, named marine RNA virus Yangshan-LWW (YS-LWW), was obtained based on metavirome assembly. The genome of YS-LWW is 8839 nt in length and contains two open reading frames (ORFs).

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Oysters are recognized as important vectors for human norovirus transmission in the environment. Whether norovirus binds to bacteria in oyster digestive tissues (ODTs) remains unknown. To shed light on this concern, ODT-54 and ODT-32, positive for histo-blood group antigen (HBGA) -like substances, were isolated from ODTs and identified as Pseudomonas composti and Enterobacter cloacae, respectively.

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Virophages are a group of small double-stranded DNA viruses that replicate and proliferate with the help of the viral factory of large host viruses. They are widely distributed in aquatic environments but are more abundant in freshwater ecosystems. Here, we mined the Global Ocean Viromes 2.

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Background: Immune checkpoint inhibitors (ICIs) have become a standard care in non-small-cell lung cancer (NSCLC). However, its application to epidermal growth factor receptor (EGFR)-mutant NSCLC patients is confronted with drug resistance. This study aimed to clarify the potential role of Yes1-associated transcriptional regulator (YAP1) in ICIs treatment for EGFR-mutant NSCLC population.

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Objective: To retrospectively analyze the clinical efficacy of olecranon osteotomy approach in the treatment of Dubberley type Ⅲ coronal fractures of the distal humerus and summarize the treatment experience.

Methods: From January 2016 to June 2020, 17 patients (5 males and 12 females) with Dubberley type Ⅲ coronal fractures of the distal humerus were treated by olecranon osteotomy approach. The age ranged from 37 to78 years old with an average of (58.

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The intron-based stabilization approach is a very useful strategy for construction of stable flavivirus infectious clones. SA-14-2 is a highly attenuated Japanese encephalitis (JE) live vaccine strain that has been widely used in China since 1989. To develop safe and effective recombinant vaccines with SA-14-2 as a backbone vector, we constructed the DNA-based infectious clone pCMW-JEV of SA-14-2 using the intron-based stabilization approach and acquired the rescued virus rDJEV, which retained the biological properties of the parental virus.

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Erlotinib is a first-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). Overcoming erlotinib resistance is crucial to improve the survival of advanced non-small cell lung cancer (NSCLC) patients with sensitive EGFR mutations. It is also an important clinical problem that urgently needs a solution.

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We have obtained an attenuated rabies virus CTN181-3. In this paper, we make a comprehensive studies on CTN181-3. CTN181-3 showed no pathogenicity by i.

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3D-QSAR models were established by collecting 46 multivariate-substituted 4-oxyquinazoline HDAC6 inhibitors. The relationship of molecular structure and inhibitory activity was studied by comparative molecular field analysis (CoMFA) and comparative molecular similarity index analysis (CoMSIA). The results showed the models established by CoMFA (q = 0.

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Since the first isolation in 1943, the dengue virus (DENV) has spread throughout the world, but effective antiviral drugs or vaccines are still not available. To provide a more stable reporter DENV for vaccine development and antiviral drug screening, we constructed a reporter DENV containing the NanoLuc reporter gene, which was inserted into the 5' untranslated region and capsid junction region, enabling rapid virus rescue by in vitro ligation. In addition, we established a live imaging mouse model and found that the reporter virus maintained the neurovirulence of prototype DENV before engineering.

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