Precise AIE-Based Ternary Co-Assembly for Saccharide Recognition and Classification.

Saccharides are involved in nearly all life processes. However, due to the complexity and diversity of saccharide structures, their selective recognition is one of the most challenging tasks. Distinct from conventional receptor designs that rely on delicate and complicated molecular structures, here a novel and precise ternary co-assembled strategy is reported for achieving saccharide recognition, which originates from a halogen ions-driven aggregation-induced emission module called p-Toluidine, N, N'-1-propen-1-yl-3-ylidene hydrochloride (PN-Tol).

Precise Capture and Dynamic Release of Circulating Liver Cancer Cells with Dual-Histidine-Based Cell Imprinted Hydrogels.

Circulating tumor cells (CTCs) detection presents significant advantages in diagnosing liver cancer due to its noninvasiveness, real-time monitoring, and dynamic tracking. However, the clinical application of CTCs-based diagnosis is largely limited by the challenges of capturing low-abundance CTCs within a complex blood environment while ensuring them alive. Here, an ultrastrong ligand, l-histidine-l-histidine (HH), specifically targeting sialylated glycans on the surface of CTCs, is designed.

Intense Left-handed Circularly Polarized Luminescence in Chiral Nematic Hydroxypropyl Cellulose Composite Films.

Integrating optically active components into chiral photonic cellulose to fabricate circularly polarized luminescent materials has transformative potential in disease detection, asymmetric reactions, and anticounterfeiting techniques. However, the lack of cellulose-based left-handed circularly polarized light (L-CPL) emissions hampers the progress of these chiral functionalizations. Here, this work proposes an unprecedented strategy: incorporating a chiral nematic organization of hydroxypropyl cellulose with robust aggregation-induced emission luminogens to generate intense L-CPL emission.

Order-order assembly transition-driven polyamines detection based on iron-sulfur complexes.

Innovative modes of response can greatly push forward chemical sensing processes and subsequently improve sensing performance. Classical chemical sensing modes seldom involve the transition of a delicate molecular assembly during the response. Here, we display a sensing mode for polyamine detection based on an order-order transition of iron-sulfur complexes upon their assembly.

HO and Phosphorylated Peptide Dual-Responsive Nanochannel Device.

Oxidation and protein phosphorylation are critical mechanisms involved in regulating various cellular activities. Increasing research has suggested that oxidative stress could affect the activities of specific kinases or phosphatases, leading to alterations in the phosphorylation status of certain proteins. Ultimately, these alterations can affect cellular signaling pathways and gene expression patterns.

Nanofluidic Device for Detection of Lysine Methylpeptides and Sensing of Lysine Methylation.

Protein methylation is the smallest possible yet vitally important post-translational modification (PTM). This small and chemically inert addition in proteins makes the analysis of methylation more challenging, thus calling for an efficient tool for the sake of recognition and detection. Herein, we present a nanofluidic electric sensing device based on a functionalized nanochannel that was constructed by introducing monotriazole-containing -sulfonatocalix[4]arene (TSC) into a single asymmetric polymeric nanochannel via click chemistry.

Visible and Reversible Restrict of Molecular Configuration by Copper Ion and Pyrophosphate.

Molecular configuration strongly impacts on its functions; however, due to complicated and diverse configuration as well as easy and rapid conversion among various configurations, research of molecular configuration is extremely difficult. If the free rotation of a molecule could be "slowed down" or even "frozen" by an external stimulus, such as ultralow temperature, then one configuration of the molecule could be captured and characterized relatively easily. Here, we show that the rotation of a hemicyanine-labeled 2-(2'-hydroxyphenyl)-4-methyloxazole (H-HPMO) molecule could be specifically and reversibly restricted by sequential additions of copper ion (Cu) and pyrophosphate (PO), reflecting as remarkable fluorescence quenching and recovery, which could be directly observed by naked eyes.

A novel near-infrared turn-on fluorescent probe for the detection of Fe and Al and its applications in living cells imaging.

In this study, a new hemicyanidine-based colorimetric-fluorescent probe L has been synthesized and characterized by X-ray single crystal diffraction, NMR, HRMS and other technologies. The probe L serves as a "turn-on" probe for the detection of Fe and Al ions in DMF-HEPES system with a high sensitivity and an excellent selectivity. The probe L manifesting the color of the solution containing L turns red on the addition of Fe, and turns pink on the addition of Al.

Coumarin-based colorimetric-fluorescent sensors for the sequential detection of Zn ion and phosphate anions and applications in cell imaging.

Two novel coumarin based fluorescent sensors CHP and CHS have been synthesized for the sequential detection of Zn ion and phosphate anion (PA) in DMF/HEPES buffer medium (1/5 v/v, 10 mM, pH = 7.4). On the addition of Zn ion to the solution of CHP or CHS resulted in a pronounced fluorescence enhancement, accompanying noticeable color change (under UV or daylight), while there was hardly obvious change with other competing metal ions co-existing.

Fluorescent schiff base probes for sequential detection of Al and F and cell imaging applications.

Two novel Schiff-base fluorescent probers SQ and NQ based on 8-hydroxyquinoline moiety were designed and synthesized. The both probes were capable of binding with Al by naked eye detection to produce a significant fluorescence enhancement response with a detection limit of 1.48 × 10 and 4.

Indole-based colori/fluorimetric probe for selective detection of Cu and application in living cell imaging.

A highly sensitive and selective indole-based probe IHT exhibited obvious color change from colorless to violet easily detected by naked eye as well as 'turn on' fluorescence response to Cu ion at physiological pH condition. The detection limit was determined to be as low as 8.93 × 10 M, which was much lower than drinking water permission concentrations by the United States Environmental Protection Agency.

A dual fluorescence probe for Zn and Al through differentially response and bioimaging in living cells.

A novel Schiff base fluorescent probe 7-Hydroxy-8-(((2-(hydroxymethyl)quinolin-8-yl)imino)methyl)-coumarin (XL) consist of formylcoumarin and aminoquinoline moieties was synthesized for dual detection of Zn and Al ions. Probe XL exhibited high selective and sensitive response towards Zn and Al ions through different color changes and significant fluorescence turn-on response (270 fold higher for Zn and 230 fold higher for Al) in MeOH-HO (4/1, v/v) over other cations, with detection limits (LOD) as low as 3.75 × 10 and 1.

A novel fluorescent-colorimetric probe for Al and Zn ion detection with different response and applications in F detection and cell imaging.

A novel Schiff base fluorescence probe (HL) was synthesized by the condensation of salicylaldehyde and an 8-aminoquinoline derivative. This probe acts as a "turn-on" dual selectivity fluorescence probe for Zn and Al ions, providing different colors and detection limits (DL) of 11.5 and 23.

A novel colorimetric-fluorescent probe for Al and the resultant complex for F and its applications in cell imaging.

A novel quinoline-based Schiff-base probe QL had been synthesized, which could sequentially monitor Al and F in MeOH-HO solution (v/v = 8/1, 0.01 M, HEPES buffer, pH = 7.3).

A novel coumarin-based fluorescent sensor for Ca and sequential detection of F and its live cell imaging.

A novel fluorescent sensor CPM for relay detecting Ca and F based on coumarin has conveniently synthesized and characterized. The sensor CPM showed highly fluorescence enhancement to Ca over other metal ions, and the CPM-Ca complex could selectively recognize F among other anions. The limits of detection for Ca and F were 5.

Novel fluorescent probes for relay detection copper/citrate ion and application in cell imaging.

Two novel fluorescent probes, 2‑(2'‑hydroxyphenyl)‑4‑(2'‑hydroxymethyl‑8‑quinolinamino)methyloxazole (L1), and 2‑(2'‑hydroxyphenyl)‑4‑(2'‑methyl‑8‑quinolinamino)methyloxazole (L2), exhibited colorimetric and "turn off" fluorometric response to Cu ion in DMSO/HO solution (v/v = 1/1, 0.01 M, Tris-HCl buffer, pH 7.20) and the corresponding detection limit were found to be 2.

A selective fluorescent probe for relay detection of Zn and tartrate: Application to logic circuit and living cell imaging.

A novel fluorescent probe 2-(2'-hydroxyphenyl)-4-(phenylethylamino)methyloxazole (HPO) has been synthesized, which performed highly selective and sensitive detection of Zn ion with a discriminating enhancement over the other metal ions. The binding constant was calculated as 3.07 × 10 M with detection limit of 1.