Publications by authors named "Yongxiang Zhang"

Diabetic nephropathy (DN) is one of the most severe kidney complications and the primary contributor to end-stage renal disease on a global scale. It exacerbates the morbidity, mortality, and financial burden for individuals with diabetes. Isoquercitrin, a natural compound found in various plants, has demonstrated potential as an antidiabetic agent.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigated the relationship between albumin-corrected serum anion gap (ACAG) levels and various mortality outcomes in type 2 diabetes (T2D) patients, indicating that hypoalbuminemia could underestimate true anion gap levels.
  • Using data from 8,161 diabetic adults over 20 years, the research found that higher ACAG levels correlated with increased rates of all-cause mortality, as well as cardiovascular and cancer-specific mortality.
  • The analysis also highlighted that certain factors, such as C-reactive protein and cholesterol levels, partially mediated the connection between ACAG levels and mortality risks, suggesting that maintaining normal ACAG levels could lower mortality risks for individuals with T2D.
View Article and Find Full Text PDF

Small-cell lung carcinoma is a high-grade aggressive disease that occurs most commonly in bronchial lung cancer, and metastasis to the heart is extremely rare. The diagnosis of metastatic small-cell lung carcinoma infiltrating the heart remains challenging because of the variability of its clinical presentation. Hereinafter, we reported a case of a 41-year-old man who suffered from small-cell lung cancer that invaded the pulmonary artery.

View Article and Find Full Text PDF

Importance: The effect of high-intensity noninvasive positive pressure ventilation (NPPV) on the need for endotracheal intubation in patients with an acute exacerbation of chronic obstructive pulmonary disease (COPD) is unknown.

Objective: To determine whether the use of high-intensity NPPV vs low-intensity NPPV reduces the need for endotracheal intubation in patients with an acute exacerbation of COPD and hypercapnia.

Design, Setting, And Participants: Randomized clinical trial conducted at 30 general respiratory non-intensive care unit wards of Chinese hospitals from January 3, 2019, to January 31, 2022; the last 90-day follow-up was on April 22, 2022.

View Article and Find Full Text PDF

With the global spread of COVID-19 posing ongoing challenges to public health systems, there is an ever-increasing demand for effective therapeutics that can mitigate both viral transmission and disease severity. This review surveys the landscape of polysaccharides derived from traditional Chinese medicine, acclaimed for their medicinal properties and potential to contribute to the COVID-19 response. We specifically focus on the capability of these polysaccharides to thwart SARS-CoV-2 entry into host cells, a pivotal step in the viral life cycle that informs transmission and pathogenicity.

View Article and Find Full Text PDF

Introduction: Obesity, a pervasive global epidemic, has heightened susceptibility to chronic ailments and diminished the overall life expectancy on a global scale. Probiotics and inulin (IN) have been documented to mitigate obesity by exerting an influence on the composition of the gut microbiota. Whether heat-killed BBMN68 (MN68) and IN have an anti-obesity effect remains to be investigated.

View Article and Find Full Text PDF

Cryptosporidiosis is considered a crucial zoonotic disease caused by widely distributing parasitic protozoa called spp. Nitazoxanide is the only FDA-approved drug but is only effective with a good immune response of the host. In addressing this unmet medical need, we previously identified a compound, namely, LN002, as a potent alternative oxidase inhibitor against cryptosporidiosis.

View Article and Find Full Text PDF

Posttranslational modifications of proteins have not been addressed in studies aimed at elucidating the cardioprotective effect of exercise in atherosclerotic cardiovascular disease (ASCVD). In this study, we reveal a novel mechanism by which exercise ameliorates atherosclerosis via lactylation. Using ApoE mice in an exercise model, proteomics analysis was used to identify exercise-induced specific lactylation of MeCP2 at lysine 271 (K271).

View Article and Find Full Text PDF

Extreme drought events have increased, causing serious losses and damage to the social economy under current warming conditions. However, short-term meteorological data limit our understanding and projection of these extremes. With the accumulation of proxy data, especially tree-ring data, large-scale precipitation field reconstruction has provided opportunities to explore underlying mechanisms further.

View Article and Find Full Text PDF

Currently, providing patients, particularly those with acute myocardial infarction (AMI), with comprehensive cardiac rehabilitation (CR) has been challenging because of the inadequate availability of medical resources in developing countries. To ensure balance between disease instability and early rehabilitation, strategies for facilitating professional and comprehensive CR opportunities for patients with AMI must be explored.A prospective cohort study was carried out on 1,533 patients with AMI who were admitted to a tertiary hospital between July 2018 and October 2019.

View Article and Find Full Text PDF
Article Synopsis
  • - The compound LN002, a phenylpyrazole derivative developed for the AOX target, shows potential effectiveness but suffers from poor water solubility, impacting its oral absorption and therapeutic potential.
  • - Researchers created solid dispersion agents using HP-β-CD and Soluplus, which transformed LN002 into an amorphous state, enhancing its solubility and dissolution rate.
  • - The optimal solid dispersion with an LN002/HP-β-CD/Soluplus ratio of 1:3:9 demonstrated significantly improved solubility and stability under certain conditions, leading to enhanced pharmacological properties and bioavailability.
View Article and Find Full Text PDF

In traditional Chinese medicine, Lycium barbarum is of rich medicinal value, and its polysaccharides are particularly interesting due to their significant pharmacological effects and potential health benefits. This study investigated the immunomodulatory effects of Lycium barbarum polysaccharides (LBPs) by examining their interaction with the TLR4/MD-2 complex and the impacts of gastrointestinal digestion on these interactions. We discovered that the affinity binding of LBPs for TLR4/MD-2 and their cytokine induction capability are influenced by molecular weight, with medium-sized LBPs (100-300 kDa) exhibiting stronger binding affinity and induction capability.

View Article and Find Full Text PDF
Article Synopsis
  • - The study addresses challenges in tissue regeneration due to the degeneration of somatic cells and loss of stem/progenitor cells, specifically focusing on intervertebral disc degeneration (IVDD).
  • - Researchers discovered that a combination of three factors (OCT4, FOXA2, TBXT) can reprogram degenerative cells into induced notochordal-like cells, aiding in potentially reversing IVDD.
  • - The technique involved single-cell transcriptomics to understand cell identity changes and utilized a viral injection method in rat models to promote cell regeneration, showing promise for treating degenerative disc diseases.
View Article and Find Full Text PDF

Objective: The possible enhancing effect of anlotinib on programmed death receptor ligand (PD-L1) antibody and the efficacy-predicting power of PD-L1 in micro-conduit endothelium, including lymphatic endothelial cells (LECs) and blood endothelial cells (BECs), were determined to identify patients who would benefit from this treatment.

Methods: PD-L1 positivity in LECs, BECs, and tumor cells (TCs) was assessed using paraffin sections with multicolor immunofluorescence in an investigator's brochure clinical trial of TQB2450 (PD-L1 antibody) alone or in combination with anlotinib in patients with non-small cell lung cancer. Progression-free survival (PFS) with different levels of PD-L1 expression was compared between the two groups.

View Article and Find Full Text PDF

The vascular disrupting agent (VDA) 5,6-dimethylxanthenone-4-acetic acid (DMXAA) induces apoptosis in vascular endothelial cells and leads to tumor hemorrhagic necrosis. While DMXAA has been proven to be a potent agonist of murine stimulator of interferon genes (mSTING), it has little effect on human-STING (hSTING). This species selectivity of DMXAA may explain its effectiveness against solid tumors in mice and its failure in clinical trials.

View Article and Find Full Text PDF
Article Synopsis
  • The paper focuses on optimizing rolling stock schedules by selecting new depot locations and capacities, which are crucial for maintenance and schedule quality.
  • It uses a two-stage mixed integer programming approach: the first stage generates various rolling stock schedules without considering maintenance, and the second stage refines these schedules to include maintenance feasibility.
  • The methodology has been tested with real-life examples, and the study discusses the results of different operational scenarios to demonstrate its effectiveness.
View Article and Find Full Text PDF

Background: The use of synbiotics is emerging as a promising intervention strategy for regulating the gut microbiota and for preventing or reducing obesity, in comparison with the use of probiotics or prebiotics alone. A previous in vivo study revealed that Lacticaseibacillus paracasei K56 (L. paracasei K56) could alleviate obesity induced in high-fat-diet mice; however, the effect of the synbiotic combination of L.

View Article and Find Full Text PDF

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection attacks the respiratory and nervous systems. Among patients with SARS-CoV-2 infection, cases with simultaneous central and peripheral nervous system damage are rare, and those with intractable hypophosphatemia and hypokalemia complicating the former have not been reported yet.

Case Presentation: A 59-year-old woman presented to the emergency department with incoherent speech evolving for 3 days.

View Article and Find Full Text PDF

To analyze the post-COVID-19 construction and management of fever clinics targeted to prevention and control of healthcare-associated respiratory viral infections in medical institutions at all levels in China, and to provide a basis for promoting their standardized construction, we conducted this survey on the construction of fever clinics in 429 medical institutions of Jiangsu Province from July to December 2020. Contents of the questionnaire included the general situation of medical institutions, the construction status and future construction plans of fever clinics. We find the construction rate of fever clinic in medical institutions of Jiangsu province was 75.

View Article and Find Full Text PDF

Viral respiratory infections are major human health concerns. The most striking epidemic disease, COVID-19 is still on going with the emergence of fast mutations and drug resistance of pathogens. A few polysaccharide macromolecules from traditional Chinese medicine (TCM) have been found to have direct anti-SARS-CoV-2 activity but the mechanism remains unclear.

View Article and Find Full Text PDF

Chronic thromboembolic pulmonary hypertension (CTEPH) plays a key role in the deterioration of lung hemodynamics and contributes to secondary dysfunction of the right heart, which is consistently accompanied by systemic malperfusion and a reduced glomerular filtration rate (GFR). The prognosis of CTEPH is markedly influenced by renal function. The aim of the present study was to evaluate the prognostic value of GFR in patients with CTEPH who have undergone balloon pulmonary angioplasty (BPA).

View Article and Find Full Text PDF

The cracked phosphorylated nanoscale zerovalent iron (p-nZVI) has a strong electron selectivity towards the reductive removal of many heavy metal ions in waters. However, the unintended environmental risk after interactions with impurities or wastewater are not involved. Therefore, in this study, the phosphate group was successfully adsorbed into p-nZVI, and the cracked p-nZVI was successfully prepared with an optimal P/Fe ratio of 0.

View Article and Find Full Text PDF

Phytoremediation is an environmentally friendly, economical, and sustainable technique for restoring farmland. It can remove heavy metals and organic pollutants from the soil through the implementation of hyperaccumulator plants. In recent years, it has garnered significant interest from academic and industrial sectors.

View Article and Find Full Text PDF