A Chebyshev collocation method for directly solving two-dimensional ocean acoustic propagation in linearly varying seabed.

It is one of the most concerning problems in hydroacoustics to find a method that can calculate the acoustic propagation accurately and adapt to the variation of the seabed. Currently, the one-dimensional spectral method has been employed to address the simplified ocean acoustic propagation model successfully. However, due to the model's application limitations and approximation error, it poses challenges when attempting to solve real-world ocean acoustic fields.

Dynamic hybrid parallel computing of the Ray Model for solving underwater acoustic fields in vast sea.

Utilizing acoustic information for search route planning will greatly increase the success rate of searching for underwater targets, which requires rapid computing of numerous underwater acoustic fields. The efficiency of traditional computing methods is too low to meet the requirements of rapid applications. In this paper, a underwater multi-acoustic fields computing model is developed based on ray theory, and multi-level hybrid parallel computing strategies are designed based on the model characteristics, and a dynamic scheduling optimization algorithm at process level is introduced to solve the load imbalance problem.

Design and implementation of a portable snapshot multispectral imaging crop-growth sensor.

The timely and accurate acquisition of crop-growth information is a prerequisite for implementing intelligent crop-growth management, and portable multispectral imaging devices offer reliable tools for monitoring field-scale crop growth. To meet the demand for obtaining crop spectra information over a wide band range and to achieve the real-time interpretation of multiple growth characteristics, we developed a novel portable snapshot multispectral imaging crop-growth sensor (PSMICGS) based on the spectral sensing of crop growth. A wide-band co-optical path imaging system utilizing mosaic filter spectroscopy combined with dichroic mirror beam separation is designed to acquire crop spectra information over a wide band range and enhance the device's portability and integration.

A spectrally discretized wide-angle parabolic equation model for simulating acoustic propagation in laterally inhomogeneous oceans.

Sound waves can be used to carry out underwater activities. Rapidly and accurately simulating sound propagation is the basis for underwater detection. The wide-angle parabolic model has a good computational speed and accuracy and is currently the main numerical model for mid- and low-frequency sound propagation.

Protein p Prediction with Machine Learning.

Protein p prediction is essential for the investigation of the pH-associated relationship between protein structure and function. In this work, we introduce a deep learning-based protein p predictor DeepKa, which is trained and validated with the p values derived from continuous constant-pH molecular dynamics (CpHMD) simulations of 279 soluble proteins. Here, the CpHMD implemented in the Amber molecular dynamics package has been employed (Huang Y.

A High-Efficiency Spectral Method for Two-Dimensional Ocean Acoustic Propagation Calculations.

The accuracy and efficiency of sound field calculations highly concern issues of hydroacoustics. Recently, one-dimensional spectral methods have shown high-precision characteristics when solving the sound field but can solve only simplified models of underwater acoustic propagation, thus their application range is small. Therefore, it is necessary to directly calculate the two-dimensional Helmholtz equation of ocean acoustic propagation.

A three-dimensional finite difference model for ocean acoustic propagation and benchmarking for topographic effects.

A three-dimensional (3D) finite difference (FD) model with formal fourth-order accuracy has been developed for the ocean acoustic Helmholtz equation (HE), which can be used to address arbitrary bathymetry and provide more accurate benchmark solutions for other 3D underwater acoustic approximate models. The derivatives in the acoustic HE are numerically discretized based on regular grids, and the perfectly matched layer is introduced to absorb unphysical reflections from the boundaries where Sommerfeld radiation conditions are deployed. The system of linear equations is solved using a parallel matrix-free geometric multigrid preconditioned biconjugate gradient stabilized iteration method, and the code (named COACH) is run on the Tianhe-2 supercomputer in China.

Two Chebyshev Spectral Methods for Solving Normal Modes in Atmospheric Acoustics.

The normal mode model is important in computational atmospheric acoustics. It is often used to compute the atmospheric acoustic field under a time-independent single-frequency sound source. Its solution consists of a set of discrete modes radiating into the upper atmosphere, usually related to the continuous spectrum.

Contribution of root uptake to cadmium accumulation in two peanut cultivars: evidence from a split-column soil experiment.

Cadmium (Cd) accumulation and internal Cd translocation in the peanut (Arachis hypogaea L.) are highly related to root uptake, which may largely depend on the cultivar variation and the depth of the Cd-contaminated soil. A split-column soil experiment was conducted using two common Chinese peanut cultivars (Huayu-20 and Huayu-23) known to relocate Cd to different tissues.

2940-nm Er:YAG fractional laser enhanced the effect of topical drug for psoriasis.

We observed the promoting effects of the 2940-nm erbium:YAG (Er:YAG) fractional laser in topical drug delivery for psoriasis. A total of five (four males and one female) recalcitrant psoriasis patients were given laser treatment eight times at 1-week intervals with the following parameters: 5-11% spot density and 100-μm energy depth. The psoriatic skin lesions on the left knee and the corresponding lesions at the right ones of each psoriasis patient were randomly divided into two groups: laser + topical drug group (L) and drug alone group (D).

The progression of CD56 myeloid sarcoma: A case report and literature review.

The current study presents a case of cluster of differentiation (CD)56 myeloid sarcoma in a patient that initially presented with skin lesions, and provides evidence for the clinical and differential diagnosis of myeloid sarcoma. The patient of the present case report was a 65-year-old man who was admitted to hospital with a six-month history of bilateral purple-red papules and nodules, which were present on the upper limbs of the patient and had spread over his whole body one month prior to admission to the hospital. Pathological examination demonstrated a diffuse infusion of primitive round cells at the papillary dermis and subcutaneous tissues.

Dermatofibrosarcoma protuberans with pit-like lesions: A case report and literature review.

The present study describes a case of pit-like dermatofibrosarcoma protuberans (DFSP) with the clinical manifestations, histopathological features and criteria for diagnosis. The study also reviews the relevant literature in order to raise awareness among dermatologists with regard to the specific behavior of DFSP. A 27-year-old female presented with subcutaneous nodules on the left side of the neck that had been apparent for 5 years and which had gradually begun caving in during the last year.

Synthesis and cell uptake of a novel dualmodality (188)Re-HGRGD (D) F-CdTe QDs probe.

A novel dualmodality probe was prepared by linking (188)Re-HGRGD (D) F with CdTe QDs, which was monitored using radio-thin layer chromatography (TLC) and -high performance liquid chromatography (HPLC). The (188)Re-HGRGD (D) F-CdTe QDs probe possesses a radiochemistry yield of 92.1% and strong photoluminescence (PL) stability.

Combined prediction of transmembrane topology and signal peptide of beta-barrel proteins: using a hidden Markov model and genetic algorithms.

Background: Hidden Markov models (HMMs) have been extensively used in computational molecular biology, for modelling protein and nucleic acid sequences. The design of the model architecture and the algorithms for parameter estimation and decoding are extremely important for improve the performance of HMM. In topology prediction of transmembrane beta-barrels proteins (TMBs), the Baum-Welch algorithm is widely adapted for HMM training but usually leads to a sub-optimal model in practice.

[Effects of all-trans retinioic acid and tazarotene on MMP-1 and TIMP-1 expression in cultured human fibroblasts after heat shock].

Objective: To investigate the molecular mechanism of dermal damage in heat shock-induced skin aging by observing the expressions of metalloproteinase-1 (MMP-1) and tissue inhibitor of MMP-1 (TIMP-1) in retinoic acid-treated cultured human fibroblasts with heat shock.

Methods: Cultured human fibroblasts were treated with tazarotene or all-trans-retinioic acid (at-RA) after heat shock for 30 min in 43 degrees celsius; water bath. Twenty-four hours later, MMP-1 and TIMP-1 contents in the supernatant of the cell culture medium were measured using enzyme-linked immunosorbent assay (ELISA).

[Prediction of outer membrane proteins using support vector machine with combined features].

Outer membrane proteins (OMPs) are embedded in the outer membrane of Gram-negative bacteria, mitochondria, and chloroplasts. The cellular location and functional diversity of OMPs makes them an important protein class. Researches on prediction of OMPs by bioinformatics methods can bring helpful methodologies for identifying OMPs from genomic sequences and for the successful prediction of their secondary and tertiary structures.

Preparation and biological evaluation of 2-amino-6-[18F]fluoro-9-(4-hydroxy-3-hydroxy-methylbutyl) purine (6-[18F]FPCV) as a novel PET probe for imaging HSV1-tk reporter gene expression.

Introduction: 2-Amino-6-[(18)F]fluoro-9-(4-hydroxy-3-hydroxy-methylbutyl) purine (6-[(18)F]FPCV) was prepared via a one-step nucleophilic substitution and evaluated as a novel probe for imaging the expression of herpes simplex virus type 1 thymidine kinase (HSV1-tk) reporter gene.

Methods: Log P of 6-[(18)F]FPCV was calculated in octanol/phosphate-buffered saline (PBS). Stability studies were performed in PBS and bovine serum albumin (BSA).

Surface modified superparamagnetic iron oxide nanoparticles: as a new carrier for bio-magnetically targeted therapy.

Amino-functionalized superparamagnetic iron oxide nanoparticles (SPION) were synthesized by coprecipitation method. The particles were characterized by X-ray diffraction (XRD), vibrating sample magnetometer (VSM), scanning electron micrographs (SEM), transmission electron micrographs (TEM) and atomic force micrographs (AFM). The size of the modified particles varied in the range 10-15 nm and did not change significantly after modification.

Radiosynthesis of 18F-(R8,15,21, L17)-vasoactive intestinal peptide and preliminary evaluation in mice bearing C26 colorectal tumours.

Background: Radiolabelled vasoactive intestinal peptide (VIP) and its analogues have shown their potential as imaging agents for diagnosing tumours expressing VIP receptor. However, the fast proteolytic degradation in vivo has limited their clinical use.

Aim: To prepare the 18F-labelled (R8,15,21, L17)-VIP analogue in a convenient way and to evaluate its potential as an imaging agent for VIP receptor-positive tumours.

Radiolabeling and in vitro and in vivo characterization of [18F]FB-[R(8,15,21), L17]-VIP as a PET imaging agent for tumor overexpressed VIP receptors.

In an effort to develop a peptide-based radiopharmaceutical for the detection of tumors overexpressed vasoactive intestinal peptide receptors with positron emission tomography, we have prepared a novel [R(8,15,21), L17]-VIP peptide for 18F-labeling. This peptide inhibited 125I-VIP binding to rats lung membranes with high affinity [half-maximal inhibitory concentrations (IC50) of 0.12 nm].

A novel method for apoptosis protein subcellular localization prediction combining encoding based on grouped weight and support vector machine.

Apoptosis proteins have a central role in the development and homeostasis of an organism. These proteins are very important for understanding the mechanism of programmed cell death. Based on the idea of coarse-grained description and grouping in physics, a new feature extraction method with grouped weight for protein sequence is presented, and applied to apoptosis protein subcellular localization prediction associated with support vector machine.