Resolution enhancement, noise suppression, and joint T2* decay estimation in dual-echo sodium-23 MR imaging using anatomically guided reconstruction.

Purpose: Sodium MRI is challenging because of the low tissue concentration of the Na nucleus and its extremely fast biexponential transverse relaxation rate. In this article, we present an iterative reconstruction framework using dual-echo Na data and exploiting anatomical prior information (AGR) from high-resolution, low-noise, H MR images. This framework enables the estimation and modeling of the spatially varying signal decay due to transverse relaxation during readout (AGRdm), which leads to images of better resolution and reduced noise resulting in improved quantification of the reconstructed Na images.

Quantitative Sodium (Na) MRI in Pediatric Gliomas: Initial Experience.

Background: 23Na MRI correlates with tumor proliferation, and studies in pediatric patients are lacking. The purpose of the study: (1) to compare total sodium concentration (TSC) between pediatric glioma and non-neoplastic brain tissue using 23Na MRI; (2) compare tissue conspicuity of bound sodium concentration (BSC) using 23Na MRI dual echo relative to TSC imaging. Methods: TSC was measured in: (1) non-neoplastic brain tissues and (2) three types of manually segmented gliomas (diffuse intrinsic brainstem glioma (DIPG), recurrent supratentorial low-grade glioma (LGG), and high-grade glioma (HGG)).

Visualizing pre-osteoarthritis: Integrating MRI UTE-T2* with mechanics and biology to combat osteoarthritis-The 2019 Elizabeth Winston Lanier Kappa Delta Award.

Osteoarthritis (OA) is a leading cause of pain and disability for which disease-modifying treatments remain lacking. This is because the symptoms and radiographic changes of OA occur after the onset of likely irreversible changes. Defining and treating earlier disease states are therefore needed to delay or to halt OA progression.

The choice of dissection or preservation of the inferior pulmonary ligament after an upper lobectomy: a systematic review and meta-analysis.

Background: The necessity of the inferior pulmonary ligament (IPL) dissection after an upper lobectomy remains controversial. This meta-analysis aimed to evaluate whether this accessional procedure could reduce the postoperative complications and improve outcomes.

Methods: PubMed, Embase, Ovid, Cochrane Library, CBM, and CNKI databases were searched for the relevant studies which compared the dissection with preservation of IPL during the upper lobectomy.

A circular echo planar sequence for fast volumetric fMRI.

Purpose: To demonstrate a circular EPI (CEPI) sequence as well as a generalized EPI reconstruction for fast fMRI with parallel imaging acceleration.

Methods: The CEPI acquisition was constructed using variable readout lengths and maximum ramp sampling as well as blipped-CAIPI z-gradient encoding for simultaneous multislice (SMS) and 3D volumetric imaging. A signal equation model with constant and linear phase terms was used to iteratively reconstruct images with low ghosting.

An eight-channel sodium/proton coil for brain MRI at 3 T.

The purpose of this work is to illustrate a new coil decoupling strategy and its application to a transmit/receive sodium/proton phased array for magnetic resonance imaging (MRI) of the human brain. We implemented an array of eight triangular coils that encircled the head. The ensemble of coils was arranged to form a modified degenerate mode birdcage whose eight shared rungs were offset from the z-axis at interleaved angles of ±30°.

[F]ML-10 PET: Initial Experience in Glioblastoma Multiforme Therapy Response Assessment.

The ability to assess tumor apoptotic response to therapy could provide a direct and prompt measure of therapeutic efficacy. F-labeled 2-(5-fluoro-pentyl)-2-methyl-malonic acid ([F]ML-10) is proposed as a positron emission tomography (PET) apoptosis imaging radiotracer. This manuscript presents initial experience using [F]ML-10 PET to predict therapeutic response in 4 patients with human glioblastoma multiforme.

Short-T imaging for quantifying concentration of sodium ( Na) of bi-exponential T relaxation.

Purpose: This work intends to demonstrate a new method for quantifying concentration of sodium ( Na) of bi-exponential T relaxation in patients on MRI scanners at 3.0 Tesla.

Theory And Methods: Two single-quantum (SQ) sodium images acquired at very-short and short echo times (TE = 0.

Challenges and Approaches to Quantitative Therapy Response Assessment in Glioblastoma Multiforme Using the Novel Apoptosis Positron Emission Tomography Tracer F-18 ML-10.

Evaluation of cancer-therapy efficacy at early time points is necessary for realizing the goal of delivering maximally effective treatment. Molecular imaging with carefully selected tracers and methodologies can provide the means for realizing this ability. Many therapies are aimed at inducing apoptosis in malignant tissue; thus, the ability to quantify apoptosis in vivo may be a fruitful approach.

Superparamagnetic iron oxide is suitable to label tendon stem cells and track them in vivo with MR imaging.

Tendon stem cells (TSCs) may be used to effectively repair or regenerate injured tendons. However, the fates of TSCs once implanted in vivo remain unclear. This study was aimed to determine the feasibility of labeling TSCs with super-paramagnetic iron oxide (SPIO) nano-particles to track TSCs in vivo using MRI.

Multi-slice parallel transmission three-dimensional tailored RF (PTX 3DTRF) pulse design for signal recovery in ultra high field functional MRI.

T(2)(∗) weighted fMRI at high and ultra high field (UHF) is often hampered by susceptibility-induced, through-plane, signal loss. Three-dimensional tailored RF (3DTRF) pulses have been shown to be an effective approach for mitigating through-plane signal loss at UHF. However, the required RF pulse lengths are too long for practical applications.

Parallel transmission RF pulse design for eddy current correction at ultra high field.

Multidimensional spatially selective RF pulses have been used in MRI applications such as B₁ and B₀ inhomogeneities mitigation. However, the long pulse duration has limited their practical applications. Recently, theoretical and experimental studies have shown that parallel transmission can effectively shorten pulse duration without sacrificing the quality of the excitation pattern.

Sodium MRI and the assessment of irreversible tissue damage during hyper-acute stroke.

Sodium MRI (sMRI) has undergone a tremendous amount of technical development during the last two decades that makes it a suitable tool for the study of human pathology in the acute setting within the constraints of a clinical environment. The salient role of the sodium ion during impaired ATP production during the course of brain ischemia makes sMRI an ideal tool for the study of ischemic tissue viability during stroke. In this paper, the current limitations of conventional MRI for the determination of tissue viability during evolving brain ischemia are discussed.

Sodium imaging of human brain at 7 T with 15-channel array coil.

Signal-to-noise ratio (SNR) is a major challenge to sodium magnetic resonance imaging. Phased array coils have been shown significantly improving SNR in proton imaging over volume coils. This study investigates SNR advantage of a 15-channel array head coil (birdcage volume coil for transmit/receive and 15-channel array insert for receive-only) in sodium imaging at 7 T.

High-resolution sodium imaging of human brain at 7 T.

The feasibility of high-resolution sodium magnetic resonance imaging on human brain at 7 T was demonstrated in this study. A three-dimensional anisotropic resolution data acquisition was used to address the challenge of low signal-to-noise ratio associated with high resolution. Ultrashort echo-time sequence was used for the anisotropic data acquisition.

High-resolution ultrashort echo time (UTE) imaging on human knee with AWSOS sequence at 3.0 T.

Purpose: To demonstrate the technical feasibility of high-resolution (0.28-0.14 mm) ultrashort echo time (UTE) imaging on human knee at 3T with the acquisition-weighted stack of spirals (AWSOS) sequence.

Improved large tip angle parallel transmission pulse design through a perturbation analysis of the Bloch equation.

Parallel transmission has emerged as an efficient means for implementing multidimensional spatially selective radiofrequency excitation pulses. To date, most theoretical and experimental work on parallel transmission radiofrequency (RF) pulse design is based on the small-tip-angle approximation to the Bloch equation. The small-tip-angle, while mathematically compact, is not an exact solution and leads to significant errors when large-tip-angle pulses are designed.

Multicomponent T2* mapping of knee cartilage: technical feasibility ex vivo.

Disorganization of collagen fibers is a sign of early-stage cartilage degeneration in osteoarthritic knees. Water molecules trapped within well-organized collagen fibrils would be sensitive to collagen alterations. Multicomponent effective transverse relaxation (T2*) mapping with ultrashort echo time acquisitions is here proposed to probe short T(2) relaxations in those trapped water molecules.

High-resolution spiral imaging on a whole-body 7T scanner with minimized image blurring.

High-resolution (approximately 0.22 mm) images are preferably acquired on whole-body 7T scanners to visualize minianatomic structures in human brain. They usually need long acquisition time ( approximately 12 min) in three-dimensional scans, even with both parallel imaging and partial Fourier samplings.

Parallel imaging with 3D TPI trajectory: SNR and acceleration benefits.

Three-dimensional (3D) twisted projection imaging (TPI) trajectory has a unique advantage in sodium ((23)Na) imaging on clinical MRI scanners at 1.5 or 3 T, generating a high signal-to-noise ratio (SNR) with a short acquisition time (approximately 10 min). Parallel imaging with an array of coil elements transits SNR benefits from small coil elements to acquisition efficiency by sampling partial k-space.

Acquisition-weighted stack of spirals for fast high-resolution three-dimensional ultra-short echo time MR imaging.

Ultra-short echo time (UTE) MRI requires both short excitation ( approximately 0.5 ms) and short acquisition delay (<0.2 ms) to minimize T(2)-induced signal decay.

Optimal coil array design: the two-coil case.

The optimization problem for coil arrays is largely unsolved, even for the case of a two-coil system. This paper reports a systematic computer simulation to investigate the maximal achievable signal-to-noise ratio (SNR) with a two-coil receiver system where, using cancellation circuitry, mutual inductance is made zero. Both symmetrical and asymmetrical solutions with respect to two-coil geometry are considered.

Decomposed direct matrix inversion for fast non-cartesian SENSE reconstructions.

A new k-space direct matrix inversion (DMI) method is proposed here to accelerate non-Cartesian SENSE reconstructions. In this method a global k-space matrix equation is established on basic MRI principles, and the inverse of the global encoding matrix is found from a set of local matrix equations by taking advantage of the small extension of k-space coil maps. The DMI algorithm's efficiency is achieved by reloading the precalculated global inverse when the coil maps and trajectories remain unchanged, such as in dynamic studies.