Sialylation-associated long non-coding RNA signature predicts the prognosis, tumor microenvironment, and immunotherapy and chemotherapy options in uterine corpus endometrial carcinoma.

Background: Sialylation in uterine corpus endometrial carcinoma (UCEC) differs significantly from apoptotic and ferroptosis pathways. It plays a crucial role in cancer progression and immune response modulation. Exploring how sialylation affects tumor behavior and its link with long non-coding RNAs (lncRNAs) may provide new insights into UCEC prognosis and treatment.

Unraveling the significance of AGPAT4 for the pathogenesis of endometriosis via a multi-omics approach.

Endometriosis is characterized by the ectopic proliferation of endometrial cells, posing considerable diagnostic and therapeutic challenges. Our study investigates AGPAT4's involvement in endometriosis pathogenesis, aiming to unveil new therapeutic targets. Our investigation by analyzing eQTL data from GWAS for preliminary screening.

Sustainable sepiolite-based composites for fast clotting and wound healing.

Uncontrolled bleeding and bacterial coinfection are the major causes of death after an injury. Fast hemostatic capacity, good biocompatibility, and bacterial coinfection inhibition pose great challenges to hemostatic agent development. A prospective sepiolite/Ag nanoparticles (sepiolite@AgNPs) composite has been prepared by using natural clay sepiolite as template.

Endoplasmic reticulum stress related IncRNA signature predicts the prognosis and immune response evaluation of uterine corpus endometrial carcinoma.

Background: Endoplasmic reticulum (ER) stress is closely related to the occurrence, development and treatment of tumors. Recent studies suggest ER stress as a therapeutic strategy of choice for cancer. However, ER stress-related long non-coding RNA (lncRNA) predictive value in endometrial carcinoma (UCEC) remains to be further evaluated.

METTL3 and METTL14-mediated N-methyladenosine modification promotes cell proliferation and invasion in a model of endometriosis.

Research Question: Could METTL3 and METTL14-mediated N-methyladenosine (mA) modification play possible cooperative roles in pathogenesis and progression of endometriosis?

Design: An investigation into mA methylation profiles and the roles of METTL3 and METTL14 in the mA regulation and pathogenesis of endometriosis. The mA methylation and mRNA levels in paired ectopic endometrium and eutopic endometrium were measured using mA-mRNA epitranscriptomic microarrays. The functions of mA methylation in mRNAs were predicted using bioinformatics analysis.

Comparison of surgical resection and radiofrequency ablation for stages I and II elderly hepatocellular carcinoma patients (≥ 65 years): A SEER population-based propensity score matching's study.

Objectives: The treatment for hepatocellular carcinoma (HCC) remains controversial and limited in elderly patients. Therefore, we aimed to explore treatment choices for the elderly patients (≥ 65years) following surgical resection (SR) versus radiofrequency ablation (RFA) with HCC (single lesion less than 5 cm).

Methods: We used SEER database to identify HCC patients who received treatment of SR/RFA.

Downregulation of circ_0000673 Promotes Cell Proliferation and Migration in Endometriosis via the Mir-616-3p/PTEN Axis.

Endometriosis is a common gynecological disease, affecting up to 10% of women of reproductive age and approximately 50% of women with infertility. Circular RNAs (circRNAs) have been shown to be involved in a number of diseases. Dysregulated expression of circRNAs in endometriosis has been reported, and circ_0000673 was significantly downregulated.

Clinical characteristics and risk factors for death in patients with bloodstream infection in Intensive Care Unit.

Objectives: To analyze the distribution of pathogens and risk factors of mortality in bloodstream infection patients in Intensive Care Unit (ICU).

Methods: The clinical data, infection relevant indexes, and prognosis of patients with bloodstream infection in ICU of Xiangya Hospital of Central South University from January 2016 to December 2020 were retrospectively collected. The distribution of pathogenic bacteria and clinical characteristics of patients with bloodstream infection were analyzed.

Regulation of exosome for Alzheimer's disease derived from mesenchymal stem cells.

Alzheimer's disease (AD) is the most common type of dementia in the elderly, accounting for about 75% of all dementia patients. The pathological feature of AD is the deposition of β-amyloid (Aβ) with strong neurotoxicity in brain tissue, while the hyperphosphorylation of tau in many neuronal cells forms neurofibrillary tangles (NFT). The combination of the two conditions leads to a large number of neuronal necrosis, disordered function of the brain, and serious cognitive dysfunction.