Enhancing low-dose radiotherapy efficacy with PARP inhibitors via FBL-mediated oxidative stress response in colorectal cancer.

The effectiveness of radiotherapy in colorectal cancer (CRC) relies on its ability to induce cell death via the generation of reactive oxygen species (ROS). However, genes responsible for mitigating oxidative stress can impede radiotherapy's efficacy. In this study, we elucidate a significant association between the nucleolar protein Fibrillarin (FBL) and the oxidative stress response in CRC tumors.

Three-dimensional ecological drought identification and evaluation method considering eco-physiological status of terrestrial ecosystems.

Ecological drought is a complex process in terrestrial ecosystems where vegetation's eco-physiological functions are impaired due to water stress. However, there is currently a lack of long-term assessment of ecological drought from an eco-physiological perspective. In this study, the standardized ecological drought index (SESNDI) was developed using actual evaporation, root soil moisture, and kernel normalized difference vegetation index via the Euclidean distance method, reflecting ecosystem physiology, water supply capacity, and vegetation status.

Population structure and antibiotic resistance of swine extraintestinal pathogenic Escherichia coli from China.

Extraintestinal Pathogenic Escherichia coli (ExPEC) pose a significant threat to human and animal health. However, the diversity and antibiotic resistance of animal ExPEC, and their connection to human infections, remain largely unexplored. The study performs large-scale genome sequencing and antibiotic resistance testing of 499 swine-derived ExPEC isolates from China.

Experimental Studies of the Machinability of SiCp/Al with Different Volume Fractions under Ultrasonic-Assisted Grinding.

High-volume fraction silicon carbide particle-reinforced aluminum (SiCp/Al) has a promising application for its high specific strength, wear resistance, and thermal conductivity. However, SiCp/Al components with a high-volume fraction are prone to poor surface quality and defects such as fractures, cracks, and micro-pits. It has been reported that ultrasonic-assisted grinding machining (UAG) helps to improve the quality of SiCp/Al machined surfaces.

A natural compound melatonin enhances the effects of Nimotuzumab via inhibiting EGFR in glioblastoma.

Sleep disorders are prevalent and debilitating symptoms in primary brain tumor patients, notably those receiving radiation therapy. Nevertheless, the relationship between sleep disorders, melatonin - a circadian rhythm regulatory hormone, and gliomas is underexplored. Melatonin exhibits various biological functions, one of them being anti-tumor activity.

Pan-cancer evaluation of regulated cell death to predict overall survival and immune checkpoint inhibitor response.

Regulated cell death (RCD) plays a pivotal role in various biological processes, including development, tissue homeostasis, and immune response. However, a comprehensive assessment of RCD status and its associated features at the pan-cancer level remains unexplored. Furthermore, despite significant advancements in immune checkpoint inhibitors (ICI), only a fraction of cancer patients currently benefit from treatments.

CYLD induces high oxidative stress and DNA damage through class I HDACs to promote radiosensitivity in nasopharyngeal carcinoma.

Abnormal expression of Cylindromatosis (CYLD), a tumor suppressor molecule, plays an important role in tumor development and treatment. In this work, we found that CYLD binds to class I histone deacetylases (HDAC1 and HDAC2) through its N-terminal domain and inhibits HDAC1 activity. RNA sequencing showed that CYLD-HDAC axis regulates cellular antioxidant response via Nrf2 and its target genes.

Orphan response regulator CovR plays positive regulative functions in the survivability and pathogenicity of Streptococcus suis serotype 2 isolated from a pig.

Background: Streptococcus suis serotype 2 (S. suis 2) is an important zoonotic pathogen. Orphan response regulator CovR plays crucial regulative functions in the survivability and pathogenicity of S.

Ectomycorrhizal fungi, two species of Laccaria, differentially block the migration and accumulation of cadmium and copper in Pinus densiflora.

The root tips of host plant species can establish ectomycorrhizae with their fungal partners, thereby altering the responses of the host plants to heavy metal (HM) toxicity. Here, two species of Laccaria, L. bicolor and L.

Discussions on Some Key Issues of Two-Dimensional Rotational Ultrasonic Combined Electro-Machining of Composite Materials.

In order to improve the surface forming quality and machining efficiency of composite materials and reduce tool wear, a two-dimensional rotary ultrasonic combined electro-machining (2DRUEM) technology with low electrical conductivity and low current density was proposed in this study. Additionally, a gap detection unit of the machining system was designed with the integration of grinding force and gap current, and the average errors and maximum errors of the model were 5.61% and 12.

Effect of Vibration Direction on Two-Dimensional Ultrasonic Assisted Grinding-Electrolysis-Discharge Generating Machining Mechanism of SiCp/Al.

This study proposes the mechanism of two-dimensional ultrasonic assisted grinding- electrolysis-discharge generating machining (2UG-E-DM). It analyzed the influence of vibration directions on grinding characteristics and surface morphology through the motion simulation of an abrasive. Comparative experiments with different vibration directions verified the effect of ultrasonic assistance on the weakening of the grinding force, the widening of the surface pits, and the leveling of the surface morphology of SiC/Al composites.

Transcription factor ZBTB42 is a novel prognostic factor associated with immune cell infiltration in glioma.

ZBTB42 is a transcription factor that belongs to the ZBTB transcript factor family and plays an important role in skeletal muscle development. Dysregulation of ZBTB42 expression can lead to a variety of diseases. However, the function of ZBTB42 in glioma development has not been studied by now.

The Association of R-Loop Binding Proteins Subtypes with CIN Implicates Therapeutic Strategies in Colorectal Cancer.

Chromosomal instability (CIN) covers approximately 65 to 70% of colorectal cancer patients and plays an essential role in cancer progression. However, the molecular features and therapeutic strategies related to those patients are still controversial. R-loop binding proteins (RLBPs) exert significant roles in transcription and replication.

Characteristics of Strain ES-2 Isolated From Chinese Native Black Pig Lungs.

is the primary pathogen of swine enzootic pneumonia and causes great economic losses to the swine industry worldwide. In China, seriously hinders the healthy development of the native black pigs. To prevent and treat porcine respiratory disease caused by , the characteristics of strain ES-2 isolated from Chinese native black pig lungs with gross lesions at post-mortem were studied for the first time in this study.

Identification of an anti-virulence drug that reverses antibiotic resistance in multidrug resistant bacteria.

The persistent incidence of high levels of multidrug-resistant (MDR) bacteria seriously endangers global public health. In response to MDR-associated infections, new antibacterial drugs and strategies are particularly needed. Screening to evaluate a potential compound to reverse antibiotic resistance is a good strategy to alleviate this crisis.

Hydrologic regime alteration and influence factors in the Jialing River of the Yangtze River, China.

Under the influence of climate alteration and human activities, the hydrological regime of rivers is changing dramatically, which has become a hot spot for water environment research. In this study, we quantitatively assessed the degree of hydrological variability of the Jialing River and the contribution of climate alteration and human activities to hydrological alterations using the ecohydrological indicator range of alteration (IHA-RVA) method and Budyko hypothesis formulations. The results showed that (1) The average annual runoff and the precipitation of Jialing River showed a decreasing trend, the potential evapotranspiration showed an increasing trend.

Recurrence- and Malignant Progression-Associated Biomarkers in Low-Grade Gliomas and Their Roles in Immunotherapy.

Despite a generally better prognosis than high-grade glioma (HGG), recurrence and malignant progression are the main causes for the poor prognosis and difficulties in the treatment of low-grade glioma (LGG). It is of great importance to learn about the risk factors and underlying mechanisms of LGG recurrence and progression. In this study, the transcriptome characteristics of four groups, namely, normal brain tissue and recurrent LGG (rLGG), normal brain tissue and secondary glioblastoma (sGBM), primary LGG (pLGG) and rLGG, and pLGG and sGBM, were compared using Chinese Glioma Genome Atlas (CGGA) and Genotype-Tissue Expression Project (GTEx) databases.

Cerebral Intraparenchymal Hemorrhage Changes Patients' Gut Bacteria Composition and Function.

Gut bacteria consists of 150 times more genes than humans that are vital for health. Several studies revealed that gut bacteria are associated with disease status and influence human behavior and mentality. Whether human brain injury alters the gut bacteria is yet unclear, we tested 20 fecal samples from patients with cerebral intraparenchymal hemorrhage and corresponding healthy controls through metagenomic shotgun sequencing.

Experimental Study on Two-Dimensional Rotatory Ultrasonic Combined Electrochemical Generating Machining of Ceramic-Reinforced Metal Matrix Materials.

According to the machining characteristics of ceramic-particle-reinforced metal matrix composites, an experimental study on difficult-to-machine materials was carried out by two-dimensional (2D) rotatory ultrasonic combined electrolytic generating machining (RUCEGM), which organically combined an ultrasonic effect with a high-speed rotating tool electrode and electrolysis. After building the one-dimensional (1D) and 2D-RUCEGM systems, the factors influencing the combined machining process were analyzed and the experiments on RUCEGM were conducted to explore the feasibility and advantages of 2D-RUCEGM. The experimental results showed that, compared with 1D-RUCEGM, 2D-RUCEGM had higher accuracy, which increased about 21% and also reduced the machining time.

Study on Generating Machining Performance of Two-Dimensional Ultrasonic Vibration-Composited Electrolysis/Electro-Discharge Technology for MMCs.

Ultrasonic vibration-composited electrolysis/electro-discharge machining technology (UE/DM) is effective for machining particulate-reinforced metal matrix composites (MMCs). However, the vibration of the tool or workpiece suitable for holes limits the application of UE/DM. To improve the generating machining efficiency and quality of flat and curved surfaces, in this study, we implemented two-dimensional ultrasonic vibration into UE/DM and constructed a novel method named two-dimensional ultrasonic vibration-composited electrolysis/electro-discharge machining (2UE/DM).

Attenuation of Strain ES-2 and Comparative Genomic Analysis of ES-2 and Its Attenuated Form ES-2L.

causes swine respiratory disease worldwide. Due to the difficulty of isolating and cultivating , very few attenuated strains have been successfully isolated, which hampers the development of attenuated vaccines. In order to produce an attenuated strain, we used the highly virulent strain ES-2, which was serially passaged 200 times to produce the attenuated strain ES-2L, and its virulence was evidenced to be low in an animal experiment.

Auranofin Has Advantages over First-Line Drugs in the Treatment of Severe Infections.

Streptococcal toxic shock-like syndrome (STSLS) likely occurs when an individual is infected with the () epidemic strain and is characterized by a cytokine storm, multiple organ dysfunction syndrome (MODS) and a high incidence of mortality despite adequate treatment. A number of antibiotics exhibit excellent bactericidal effects in vivo, such as fluoroquinolones, aminoglycosides (gentamicin) and β-lactams (penicillin G, ceftiofur, or amoxicillin), but are less effective for treating STSLS. Therefore, there is an urgent need to identify new compounds that can reduce the damage caused by STSLS.

RcsB-dependent regulation of type VI secretion system in porcine extra-intestinal pathogenic Escherichia coli.

Signal transduction system and specialized secretory devices are crucial for bacteria to sense and adequately adapt in adverse environmental conditions. Therefore, it's crucial for microbes to detect and respond to lethal attacks when envelope is perturbed so as to minimize and fix the damage in milieu. We investigated the adaptive response of porcine extra-intestinal pathogenic Escherichia coli PCN033 to polymyxin B challenge.

Effect of the Anisotropy Mechanical Properties on LN Crystals Fixed-Abrasive Lapping.

The anisotropy of lithium niobate (LN) single crystals in mechanical properties affects its material removal uniformity during lapping. The nano-indentation hardness () and elastic modulus() of Z-cut wafer and X-cut wafer were measured by a nano-indentation tester. The nano-scratching tests were adopted to evaluate its critical cutting depth () of brittle ductile transition along crucial orientations of Z-cut and X-cut, respectively.

Rapid and label-free identification of different cancer types based on surface-enhanced Raman scattering profiles and multivariate statistical analysis.

Rapid detection and classification of cancer cells with label-free and non-destructive methods are helpful for rapid screening of cancer patients in clinical settings. Here, surface-enhanced Raman scattering (SERS) was used for rapid, unlabeled, and non-destructive detection of seven different cell types, including human cancer cells and non-tumorous cells. Au nanoparticles were used as enhanced substrates and directly added to cell surfaces.