Study of medical radioisotope production of Ac-225 by proton accelerator.

Ac radionuclides have shown great potential for use as radiopharmaceuticals in cancer therapy by conjugation them with carrier molecules due to their strong cytotoxicity, suitable half-life, and ability to be used as Bi generators. The production of Ac via bombardment of Th targets with accelerated protons is currently the most widely used method in the world. In order to better quantify the achievable yields and radiopurity, this production process is simulated in this study.

AI-Based Automated Quantification of Arterial Stenosis in Head and Neck CT Angiography: A Comparison with Manual Measurements from Digital Subtraction Angiography and CT Angiography.

Purpose: To evaluate the performance of an artificial intelligence (AI) algorithm for automated quantification of arterial stenosis in head and neck CT angiography (CTA).

Methods: Patients who received head and neck CTA and DSA between January 2019 and December 2021 in two centers were included. The quantitative performance of CerebralDoc per-lesion was evaluated through intraclass correlation coefficients (ICCs) and Bland-Altman analysis, comparing automated stenosis measurements and manual measurements across 0-100%, < 50%, ≥ 50% and ≥ 70% thresholds.

Self-management experiences in fall prevention among community-dwelling older adults in China: a descriptive qualitative study.

Background: Falls are the most common injuries in older adults, and fall prevention is one of the primary measures to achieve healthy aging. Self-management refers to the measures taken by individuals to avoid various adverse factors and health damage to protect and promote their health. This study aimed to explore the factors and measures of self-managed fall prevention among community-dwelling older adults.

Added value of artificial intelligence solutions for arterial stenosis detection on head and neck CT angiography: A randomized crossover multi-reader multi-case study.

Purpose: The purpose of this study was to investigate the added value of artificial intelligence (AI) solutions for the detection of arterial stenosis (AS) on head and neck CT angiography (CTA).

Materials And Methods: Patients who underwent head and neck CTA examinations at two hospitals were retrospectively included. CTA examinations were randomized into group 1 (without AI-washout-with AI) and group 2 (with AI-washout-without AI), and six readers (two radiology residents, two non-neuroradiologists, and two neuroradiologists) independently interpreted each CTA examination without and with AI solutions.

A Comparative Study of AI-Based Automated and Manual Postprocessing of Head and Neck CT Angiography: An Independent External Validation with Multi-Vendor and Multi-Center Data.

Purpose: To externally validate the performance of automated postprocessing (AP) on head and neck CT Angiography (CTA) and compare it with manual postprocessing (MP).

Methods: This retrospective study included head and neck CTA-exams of patients from three tertiary hospitals acquired on CT scanners from five manufacturers. AP was performed by CerebralDoc.

Performance of deep learning-based autodetection of arterial stenosis on head and neck CT angiography: an independent external validation study.

Purpose: To externally validate the performance of automated stenosis detection on head and neck CT angiography (CTA) and investigate the impact factors using an independent bi-center dataset with digital subtraction angiography (DSA) as the ground truth.

Material And Methods: Patients who underwent head and neck CTA and DSA between January 2019 and December 2021 were retrospectively included. The degree of stenosis was automatically evaluated using CerebralDoc based on CTA.

Radiation characteristics analysis for spallation products of lead-bismuth target and tungsten-iron-nickel target.

The radiation characteristics of spallation products are important references for evaluating the materials used as spallation targets. Therefore, it is necessary to study the radiation characteristics of spallation products. In this study, the spallation products of tungsten-iron-nickel target and lead-bismuth target were calculated and analyzed based on the radionuclide distributions and decay photon shielding of the spallation products.

Relationships between children-related factors, basic psychological need satisfaction, and multiple happiness among urban empty-nesters in China: a structural equation modeling.

Background: Aging and empty-nesting in China are becoming more and more serious. Empty-nesters refer to older adults who were not living with their children, were living alone, or were living independently with their spouses. The mental health of empty-nesters needs timely attention.

Development of the Home-Based Fall Prevention Knowledge (HFPK) questionnaire to assess home-based fall prevention knowledge levels among older adults in China.

Background: Falls are one of the main reasons for mortality and morbidity in older adults. However, despite adoption of prevention strategies, the number of falls in older adults has not declined. This study aimed to develop a questionnaire to assess fall prevention knowledge and explore associated factors among Chinese community-dwelling older adults.

Effects of teach-back health education (TBHE) based on WeChat mini-programs in preventing falls at home for urban older adults in China: a randomized controlled trial.

Background: Falls are common among adults aged 60 years and older because of physiological changes. Most falls in older adults occur most often at home. Coupled with the lack of awareness and knowledge of preventing falls, the proportion of injuries and deaths among older adults due to falls is increasing yearly.

Reliability and Validity of the Chinese Nine-Item Basic Psychological Need Satisfaction Scale Based on Self-Determination Theory With Older Adults.

Self-determination theory distinguishes three basic human psychological needs: competence, relatedness, and autonomy. The measurement of these needs in populations of older adults has been limited and inadequate. Yet, results from such an assessment are likely to be valuable in policymaking, specifically toward the goal of healthy aging.

The Feature Description of Formal Context Based on the Relationships among Concept Lattices.

Three-way concept analysis (3WCA) is extended research of formal concept analysis (FCA) by combining three-way decision. The three-way object oriented concept lattice (OEOL) is one of the important data structures which integrates rough set, concept lattice and three-way decision in 3WCA. In the paper, we investigate the characteristics of formal context based on the isomorphic relationship among the kinds of concept lattices with OEOL.

High expression of RRM2 as an independent predictive factor of poor prognosis in patients with lung adenocarcinoma.

Ribonucleotide reductase subunit M2 may play a role as a potential prognostic biomarker in several cancers. In this study, we evaluated whether gene expression is associated with the prognosis of patients with lung adenocarcinoma (LUAD) using publicly available data from The Cancer Genome Atlas (TCGA). Wilcoxon signed-rank test and logistic regression were performed to evaluate the association between expression and clinical features in patients with LUAD.

A functional Variant (Rs35592567) in TP63 at 3q28 is Associated with Gastric Cancer Risk via Modifying its Regulation by MicroRNA-140.

Background/aims: TP63 was believed to play an important role in the development of many malignancies, while the polymorphisms located at the miRNA binding sites within the 3'UTR of TP63 mRNA may interfere with its expression. In this study, we aimed to study the role of TP63 regulation in the tumorigenesis of gastric cancer (GC).

Methods: Computational and luciferase analysis were used to search and confirm the target of miR-140.

Therapeutic evaluation of video-assisted thoracoscopic surgery versus open thoracotomy for pediatric pulmonary hydatid disease.

Background: Hydatid disease is a severe and widespread human cestode infection, and in children, the lung is the most commonly infected organ. In current practice, the standard surgical procedure for the removal of pulmonary hydatid cysts is thoracotomy; therefore, we evaluated the efficacy and safety of video-assisted thoracoscopic surgery (VATS) to treat pediatric pulmonary hydatid disease. To our knowledge, this is the first and large sample comparative study of VATS and thoracotomy for pediatric pulmonary hydatid disease.

Video-Assisted Thoracoscopic Surgery for Treatment of Chronic Obstructive Pulmonary Disease.

The aim of this study is to evaluate the safety and efficacy of lung volume reduction surgery (LVRS) by video-assisted thoracoscopic surgery (VATS) in the treatment of chronic obstructive pulmonary disease (COPD). A total of 90 patients with COPD from 2002 to 2012 were enrolled into our study, comprising 22 who underwent conventional thoracotomies and 68 VATS. Pulmonary function testings, arterial blood gases analysis, and quality of life between these two groups were compared.

Influence of Heparanase and VEGF-C mRNA Expressions in Lung Cancer.

The objective of this study is to investigate relationship between the expressions of heparanase and vascular endothelial growth factor-C (VEGF-C) mRNA and tumorigenesis, progression in human lung cancer. The expressions of heparanase and VEGF-C mRNA in 65 cases of lung cancer (31 cases of squamous cell carcinoma, 25 adenocarcinoma, 3 large cell carcinoma, and 6 small cell carcinoma), adjacent tissues of cancer, and normal tissues were tested by reverse transcription-polymerase chain reaction (RT-PCR) and analyzed by clinico-pathological characteristics and prognosis of lung cancer. The rate of expressions of heparanase and VEGF-C mRNA in tumor tissues (55.

Effect of Second mitochondria-derived activator of caspase in combination with Docetaxel on lung cancer cell A549.

This study was to investigate inhibiting effect of structurally unique Second mitochondria-derived activator of caspase (Smac) in combination with Docetaxel on lung cancer cell line A549. Results showed that the expression of Smac in transfected A549 cells was higher than the control cells both at mRNA level and protein level (P<0.05).

LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer.

LASP1 is an actin-binding protein associated with actin assembly dynamics in cancer cells. Here, we report that LASP1 is overexpressed in pancreatic ductal adenocarcinoma (PDAC) where it promotes invasion and metastasis. We found that LASP1 overexpression in PDAC cells was mediated by HIF1α through direct binding to a hypoxia response element in the LASP1 promoter.

Characterizations of MV-algebras based on the theory of falling shadows.

Based on the falling shadow theory, the concept of falling fuzzy (implicative) ideals as a generalization of that of a T ∧-fuzzy (implicative) ideal is proposed in MV-algebras. The relationships between falling fuzzy (implicative) ideals and T-fuzzy (implicative) ideals are discussed, and conditions for a falling fuzzy (implicative) ideal to be a T ∧-fuzzy (implicative) ideal are provided. Some characterizations of falling fuzzy (implicative) ideals are presented by studying proprieties of them.

Effects of gamma irradiation and moist heat for sterilization on sodium alginate.

Polysaccharides, such as alginates, are already being used as carriers for drug delivery. The physicochemical and biological properties of alginates may be affected via irradiation and thermal treatments. To explore and compare effects of two kinds of sterilization methods, gamma irradiation and moist heat, on sodium alginate (SA), physicochemical and biological properties of SA powder and solutions were investigated after sterilization.