Adverse event of Sinovac Coronavirus vaccine: Deafness.

COVID-19 has spread worldwide and is one of the most threatening infectious diseases in the world. Vaccination is known as an effective method to protect susceptible populations against such diseases. The Coronavirus vaccine developed by Sinovac has been shown to have a high protective effect, but it also has potential adverse events.

Use of Solid Lipid Nanoparticles for the Treatment of Acute Acoustic Stress-Induced Cochlea Damage.

To study the effects of drug delivery using solid lipid nanoparticles in the treatment of acute noise exposure-induced cochlea damage. The solid lipid nanoparticles (SLNs) were used as carriers to effectively encapsulate the drug clozapine, improve drug stability in the carrier system, and increase drug bioavailability . Solid lipid nanoparticles carrying clozapine were produced by ultrasonic technology.

Cochlear Transfection Gene Guinea Pigs Mediates Atoh1-EGFP Based Hyaluronic Acid Modified Polyethyleneimine Nanoparticles.

To modify polyethyleneimine (PEI) nanoparticles using hyaluronic acid (HA) to prepare a novel nonviral vector and use it to coat Atoh1-EGFP plasmid to detect its translocation in living guinea pig cochlea dyeing efficiency. Atoh1-EGFP plasmid was extracted and characterized using a Zetasizer particle size analyzer. HA/PEI/DNA complexion was characterized and introduced into the round window membrane.

[Clinical application of the combined presigmoid supra-infratentorial approach].

Objective: To explore the surgical approach to the lesions of the cerebellopontine angle and the petroclival region.

Method: Nine cases of the cerebellopontine angle or petroclival large tumors and one case of the posterior cerebral thrombotic aneurysm were treated by the combined presigmoid supra-infratentorial approach. The tumors including 3 cases of schwannomas and 6 cases of meningiomas spaned supra-infratentorium in our study.

[Combined frontal-preauricular-cervical approach for resection of huge transcranial lateral skull base tumors].

Objective: To search into the appropriate approach for surgical treatment of the huge lateral skull base tumors.

Methods: The combined frontal-preauricular-cervical approach was used in two cases with huge transcranial lateral skull base tumors occupying the parapharngeal space, infratemporal fossa and middle cranial fossa. To acquire a wide surgical exposure, the flaps of orbital-zygomatic bone and the skull bone were removed, and then the mandibula was dislocated inferiorly.