Spectrochim Acta A Mol Biomol Spectrosc
March 2022
HClO/ClO, as one of important reactive oxygen species, is a highly reactive unavoidable by-product generated from normal cell metabolism. In recent years, efficient method for detectiing HClO/ClO is of great important to research its pathological or physiological function in bio-systems. In this work, we have constructed a fluorescent probe (P-Hc) with ratiometric signal for sensing HClO/ClO in aqueous solution, physiological saline and different serums based on 2-(benzo[d]thiazol-2-yl)phenol dye.
View Article and Find Full Text PDFThe aim of this study is to investigate whether systemic 5-hydroxytryptamine (5-HT) can promote long-lasting form of respiratory plasticity in vivo via 5-HT2AR-activated protein kinase C (PKC) mechanism. The frequency and peak amplitude of hypoglossal nerve discharges in anesthetized rats were compared before and after intravenous injections of different treatments, including saline, 5-HT, ketanserin tartrate, or staurosporine. The administration of 5-HT at a systemic bolus imposed an initial ephemeral inhibition subsequently followed by striking facilitation, which demonstrates a biphasic manner of hypoglossal nerve output in anesthetized adult rats.
View Article and Find Full Text PDFBackground: It is known that there is a genetic predisposition to OSAHS. Polymorphisms of the 5-hydroxytryptamine (5-HT) 2A/2C receptors (5-HTR 2A/2C) genes and 5-HT transporter (5-HTT) gene may be associated with the pathogenesis of obstructive sleep apnea-hypopnea syndrome (OSAHS).
Objectives: In this study, we aimed to investigate the prevalence of polymorphisms of the 5-HTR 2A/2C genes and the 5-HTT gene in the Chinese Han OSAHS population.