A Biolayer Interferometry-Based SARS-COV-2 Mpro-Targeted Active Ingredients Recognition System: Construction and Application in Ligand Screening From Herbal Medicines.

Introduction: Drug discovery research targeting SARS-CoV-2 and other emerging pathogens remains critically important. Active compounds derived from plants frequently serve as lead compounds for further drug discovery; however, numerous unrelated chemical constituents in crude extracts may obscure the effective ingredients in LC-MS analysis.

Objective: The aim of this study is to construct a biolayer interferometry (BLI)-based system for recognizing active ingredients that inhibit the main protease (Mpro) of SARS-CoV-2 and to identify the active chemical components binding to Mpro from herbal medicines.

IDOD-YOLOV7: Image-Dehazing YOLOV7 for Object Detection in Low-Light Foggy Traffic Environments.

Convolutional neural network (CNN)-based autonomous driving object detection algorithms have excellent detection results on conventional datasets, but the detector performance can be severely degraded in low-light foggy weather environments. Existing methods have difficulty in achieving a balance between low-light image enhancement and object detection. To alleviate this problem, this paper proposes a foggy traffic environment object detection framework, IDOD-YOLOV7.

First Report of Puccinia engleriana Causing Leaf Rust of Tabernaemontana bufalina in Hainan, China.

Tabernaemontana bufalina Lour. is extensively cultivated as an ornamental plant in Hainan, Guangdong, and other regions of southern China. In January 2020, we observed a rust disease on T.

Identification of microRNA-451a as a Novel Circulating Biomarker for Colorectal Cancer Diagnosis.

Background: Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. Successful treatment of CRC relies on accurate early diagnosis, which is currently a challenge due to its complexity and personalized pathologies. Thus, novel molecular biomarkers are needed for early CRC detection.

Effects of dexmedetomidine on the expression of inflammatory factors in children with congenital heart disease undergoing intraoperative cardiopulmonary bypass: a randomized controlled trial.

Importance: Dexmedetomidine inhibits the inflammatory response associated with cardiopulmonary bypass (CPB) and protects neural function. However, the mechanism of dexmedetomidine's anti-inflammatory pathway is unclear.

Objective: To investigate the effect of dexmedetomidine on the cognitive level and expression of inflammatory factors in children with congenital heart disease undergoing intraoperative CPB.

Anesthetic management of children with congenital insensitivity to pain with anhidrosis.

Introduction: Congenital analgesia is a rare autosomal recessive hereditary disease. The primary damage of congenital analgesia is central structure damage of comprehensive pain perception.

Case Presentation: A 1-year-old Han Chinese boy was admitted to hospital because of a tongue bite.

End-tidal carbon dioxide monitoring revealed severe complications during cardiothoracic surgery.

Introduction: With the continuous progress being made in medicine and surgery, increasingly more advanced technology and monitoring equipment are being used in anesthesia, end-tidal carbon dioxide (PETCO ) monitoring revealed serious complications of cardiothoracic surgery.

Case Presentation: A 3-year-old boy with a body weight of 15 kg presented with a >1-month history of a heart murmur. At the moment of arterial catheter ligation, the PETCO decreased from 37 to 15 mmHg, while the blood pressure, heart rate, and airway resistance did not change significantly.

Pectoralis major myocutaneous flap in salvage reconstruction following free flap failure in head and neck cancer surgery.

Objective: This study aimed to compare the results of the pectoralis major myocutaneous (PMM) flap in primary and salvage head and neck cancer surgery.

Methods: A total of 160 patients were enrolled in this study. The salvage group consisted of 30 patients who received immediate PMM flap surgery following free flap failure.

Anesthesia with propofol-remifentanil combined with rocuronium for bronchial foreign body removal in children: Experience of 2 886 cases.

Importance: The appropriate anesthetic method can reduce the complications of children with tracheal foreign body and reduce the mortality rate of children. What kind of anesthetic method to choose has always been the focus of debate.

Purpose: To evaluate the efficacy and safety of anesthesia with propofolremifentanil combined with rocuronium for foreign body aspiration (FBA) removal with the positive-pressure ventilation technique.