Publications by authors named "Yongsheng Jia"

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  • A clinical trial compared the effectiveness and safety of gemcitabine plus capecitabine (GX) versus gemcitabine plus carboplatin (GC) in treating advanced triple-negative breast cancer (TNBC) patients.
  • The results showed that while median progression-free survival (PFS) was similar, the GC regimen was more effective, particularly in patients with high tumor-infiltrating lymphocytes (TILs).
  • The GX regimen is still considered for patients who might struggle with the side effects associated with the GC treatment, particularly hematological toxicity.
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  • USP4 is an oncogenic factor that is highly expressed in papillary thyroid carcinoma (PTC) tumors and is linked to aggressive features and poor prognosis.
  • Silencing USP4 significantly reduces the proliferation of PTC cells and reveals its role in stabilizing the LDHA protein through deubiquitination.
  • The study highlights the USP4/LDHA interaction as crucial for PTC progression via the modulation of MAPK and AKT signaling pathways, suggesting USP4 as a potential target for therapy.
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Monitoring the building blast vibration signal is an efficient way to determine the power of blast vibration hazards. Due to the harsh measurement environment, noise is inevitably introduced into the recorded signals. This research presents a denoising approach based on Improved complete ensemble empirical mode decomposition with adaptive noise(ICEEMDAN) and Composite Multiscale Permutation Entropy (CMPE).

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  • Circular RNAs (circRNAs) like circ_0084653, which arises from the COPS5 gene, are increasingly recognized for their role in triple-negative breast cancer (TNBC) and are shown to be upregulated in TNBC cells.* -
  • Knockdown of COPS5 resulted in decreased cell proliferation, invasion, and other cancer traits, while circ_0084653 silence also inhibited TNBC progression, indicating a regulatory relationship between these molecules and cancer development.* -
  • circ_0084653 enhances TNBC by deubiquitinating the MYC protein through USP36 recruitment and acting as a sponge for miR-1323, subsequently increasing the expression of the SOX5 gene, which
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The area of permafrost worldwide accounts for approximately 20% to 25% of land area. In cold-climate regions of China, which are garnering international attention, the study of low-temperature and moisture effects on rock mass mechanical properties is of significant importance. China has a wide area of cold regions.

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To fully exploit pore engineering in the design of more efficient zeolite adsorbents for volatile organic compound (VOC) treatment, the roles of meso- and micropores need to be clarified to provide the theoretical basis and feasible measures. In this work, the three VOC sorption properties of conventional and hierarchical porous beta zeolites were comparatively investigated to study the roles of meso- and micropores. There is a division of functions between micro- and mesopores, with micropores being the main VOC adsorption sites and mesopores greatly enhancing VOC diffusion and adsorbent reusability.

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Highly crystalline nano-MFI-type zeolites containing different elements were synthesized, and the sorption effects of the elements on volatile organic compounds (VOCs) were investigated. The results showed that the optimal toluene and acetone breakthrough time of the synthesized zeolites was 2.1 and 1.

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In order to analyze the axial compressive properties of ultra-high-toughness cementitious composite (UHTCC)-confined recycled aggregate concrete (RAC), a batch of UHTCC-confined RAC components was designed and manufactured according to the requirements of GB/T50081-2002 specifications. After analyzing the surface failure phenomenon, load-displacement curves, scanning electron microscope (SEM), and parameter analysis of the specimen, the result shows that UHTCC-confined RAC is an effective confinement method, which can effectively improve the mechanical properties and control the degree of surface failure of RAC structures. Compared with the unconfined specimen, the maximum peak load of the UHTCC confinement layer with a thickness of 10 mm and 20 mm increased by 44.

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  • Metaplastic breast cancer (MpBC) is a highly aggressive form of breast cancer characterized by various subtypes, with a significant portion being mixed (45.1%), and a majority being triple-negative (69.6%).
  • The study analyzed data from 217 MpBC patients and found that their survival rates are worse compared to those with invasive ductal carcinoma of no special type (IDC-NST), with important prognostic factors including tumor subtype and chemotherapy treatment.
  • Overall, MpBC patients have poorer prognoses than IDC-NST patients; mixed MpBC exhibits the most aggressive characteristics, while pure and heterologous mesenchymal differentiation subtypes tend to have better survival outcomes.
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Si-containing transition-metal nitrides TiSiN, ZrSiN and HfSiN with conventional rock salt B1 structure exhibit superior hardness, strength and oxidation resistance. However, the potential phases of the ternary systems at various pressures remain unexplored. In this work, we firstly studied the potential structures of TiSiN, ZrSiN and HfSiN in pressures of 0-100 GPa.

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In this study, polyurea was experimentally tested under various spraying temperatures and pressures. The number of holes and the pore size produced after the tensile fracture of the polyurea were counted to illustrate the effect of the various spraying temperatures and pressures on the performance of the polyurea. The tensile characteristics of polyurea were greatly influenced by the spraying temperatures and pressures, according to the experimental findings and statistical analysis.

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The rapid heat loss and corrosion of nano-aluminum limits the energy performance of metastable intermolecular composites (MICs) in aquatic conditions. In this work, superhydrophobic n-Al/PVDF films were fabricated by the cryogel-templated method. The underwater ignition performance of the energetic films was investigated.

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Although there have been significant advances in research and treatments over the past decades, cancer remains a leading cause of morbidity and mortality, mostly due to resistance to standard therapies. Pulsed electromagnetic field (PEMF), a newly emerged therapeutic strategy, has been highly regarded as less invasive and almost safe to patients, is now a clinically accepted form to treat diseases including cancer. Breast and lung cancer are the most prevalent forms of human cancers, yet reported investigations on exploring regimes including PEMF are limited.

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  • The study focuses on using circulating tumor DNA (ctDNA) methylation as a non-invasive biomarker for early cancer detection, specifically in breast cancer patients, tackling challenges like low ctDNA availability and complex DNA variations.
  • Researchers analyzed three cohorts from hospitals in China, developing a specialized ctDNA sequencing technology that requires minimal plasma input and offers comprehensive genome-wide coverage.
  • Results showed that a diagnostic signature of 15 ctDNA methylation markers can accurately identify both early and advanced breast cancer stages, as well as discern estrogen receptor status and differentiate between various cancer types.
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The prefabricated artificial filled jointed rock specimens are impacted by a self-made drop hammer impact device for many times, and the specimens with different degrees of cumulative damage characteristics are obtained. Then, the static and dynamic compression mechanical properties are studied by using universal testing machine and SHPB device. Through the static compression test, the strength and deformation characteristics of jointed rock specimens after multiple impacts are obtained, and the influence of the damage degree of jointed rock specimens characterized by wave velocity on the compressive strength of filled joints is analysed.

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Objective: The clinical features of solitary pulmonary nodules (SPN) in breast cancer patients were retrospectively analyzed, and the clinical features of primary lung cancer (PLC) and metastatic pulmonary breast cancer (MBC) in breast cancer patients were compared, and the treatment plan, curative effect and influencing factors were analyzed.

Methods: The clinical data of 106 patients of SPN combined with breast cancer surgery in our hospital from January 2015 to June 2020 were analyzed. There were 65 patients of PLC and 41 patients of MBC.

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  • * Conducted as a phase I trial, it involved both single-dose (one-time injection) and multiple-dose (daily for 14 days) parts, focusing on three different dose levels: 5 mg/m, 7.5 mg/m, and 10 mg/m.
  • * The results indicated that rh-endostatin had no dose-limiting toxicity, was generally well-tolerated, and showed predictable pharmacokinetic properties, though a few patients experienced mild cardiotoxicity and other minor side effects.
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This work established a high-speed camera-assisted visualization system that investigated the effect of volatile matter and fixed carbon content in biomass particles on single-particle combustion phases and their luminous properties. Three types of biomass particles, namely, sawdust (a mixture of pine and willow), corncob, and rice husk, were examined on a Hencken flat-flame burner. The luminous region and intensity of single biomass particles were closely related to the flammability and calorific value of biomass fuel and derived by analyzing a sequence of images captured using a high-speed camera.

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This study aimed to investigate the metastasis patterns and prognosis of breast cancer (BC) in patients aged ≥ 80 years with distant metastases, as the current literature lacks studies in this population. A retrospective, population-based study using data from the Surveillance, Epidemiology, and End Results (SEER) database was conducted to evaluate 36,203 patients with BC from 2010 to 2016. Patients were classified into three groups, the older group (aged ≥ 80 years), middle-aged group (aged 60-79 years), and younger group (aged < 60 years).

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Objectives: The efficiencies of osteogenesis and angiogenesis present challenges that need to be overcome before bone tissue engineering can be widely applied to clinical uses. We aimed to optimize an culture system to enhance osteogenesis and angiogenesis. We investigated if hematopoietic stem cells (HSCs) promoted osteogenesis when co-cultured with mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs).

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  • HER2 breast cancer is a challenging problem, especially when it’s advanced or spread to other body parts.
  • Researchers found that a special part of the immune system (Th1 immune response) can help remove HER2, a protein that makes cancer cells grow, by increasing a protein called CUL5.
  • Using a kind of treatment that includes IFN-γ and anti-HER2 vaccinations together with other therapies could help shrink tumors and fight against this type of breast cancer.
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Metastasis is associated with poor prognosis in cancer and is a multistep process that includes invasion and migration. Several epigenetic factors are involved in this process, including chromobox protein homolog 8 (). Here, we show that is overexpressed in many cancers compared with normal tissues.

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  • Large amounts of long noncoding RNAs (lncRNAs) play important roles in breast cancer, with HAND2-AS1 specifically shown to suppress various cancers but its role in breast cancer was previously unclear.
  • In this study, HAND2-AS1 was found to be underexpressed in breast cancer cell lines, and increasing its levels led to reduced cell growth, migration, and invasion while promoting cell death.
  • HAND2-AS1 functions by binding to miR-3118, which is elevated in breast cancer, and this interaction helps regulate the expression of PHLPP2, ultimately inhibiting breast cancer progression.
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Background: Previous studies have shown that vinorelbine/capecitabine (NX) and docetaxel/capecitabine (TX) chemotherapy has a certain effect in advanced breast cancer. However, there are few clinical studies directly comparing TX and NX regimen chemotherapy, especially in patients with advanced breast cancer previously treated with anthracycline and taxane. The purpose of this Phase II study was to compare survival and side effects between patients with anthracycline- and taxane-resistant advanced breast cancer treated with NX and those treated with TX chemotherapy.

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